A5115600547- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Enzyme Catalysis and Immobilization
- Synthesis and Properties of Aromatic Compounds
- Luminescence and Fluorescent Materials
- Lipid metabolism and biosynthesis
- Organoboron and organosilicon chemistry
- Eosinophilic Esophagitis
- Fatty Acid Research and Health
- Protein Hydrolysis and Bioactive Peptides
- Cancer Immunotherapy and Biomarkers
- Entomopathogenic Microorganisms in Pest Control
- Plant Stress Responses and Tolerance
- Fungal Biology and Applications
- Plant responses to water stress
- Endoplasmic Reticulum Stress and Disease
- Alkaloids: synthesis and pharmacology
- Algal biology and biofuel production
- interferon and immune responses
- Microbial Metabolic Engineering and Bioproduction
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Reproductive System and Pregnancy
- Electrochemical sensors and biosensors
- Vibrio bacteria research studies
Yunnan University of Traditional Chinese Medicine
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Peking University
1990-2024
Beijing University of Chemical Technology
2024
Nanjing Agricultural University
2024
New Technology (Israel)
2023
National Health and Family Planning Commission
2023
Nankai University
2022
Jiangsu University of Science and Technology
2013-2019
Boron-embedded heteroacenes (boraacenes) have attracted enormous interest in organic chemistry and materials science. However, extending the skeleton of boraacenes to higher acenes (N≥6) is synthetically challenging because their limited stability under ambient conditions. Herein, we report synthesis boron-embedded heptacene (DBH) nonacene (DBN) as hitherto longest boraacenes. The former highly stable (even after 240 h tetrahydrofuran), while latter air-sensitive with half-life (t1/2 ) 11.8...
Background/Objectives: Stephania epigaea is a plant from the Menispermaceae family. Its root an important traditional folk medicine, which called Diburong in China. rich benzylisoquinoline alkaloids (BIAs), including cepharanthine, has been demonstrated to exhibit significant anti-inflammatory, antiviral, antineoplastic, and anti-SARS-CoV-2 activities, as well raising leukocytes. Cepharanthine composed of (R)- (S)-1-benzylisoquinoline alkaloid (1-BIA). (S)-norcoclaurine-6-O-methyltransferase...
Desilked silkworm ( Bombyx mori L .) pupae oil has been identified as a valuable source of unsaturated fatty acids (UFAs). However, direct consumption is food safety issue due to the presence sn ‐1,3 triacylglycerols (TAGs), including palmitic acid (PA). A simple, selective and safe conversion structured (STAGs) with high UFA content highly desirable. Novel STAGs low PA α ‐linolenic (ALA), oleic (OA) linoleic (LA) were synthesized from using solvent‐free system catalyzed by Lipozyme RM IM....
Tissue-resident Natural Killer (trNK) cells are crucial components of local immunity that activate rapidly upon infection. However, under steady state conditions, their responses tightly controlled to prevent unwanted tissue damage. The mechanisms governing differentiation and activation not fully understood. Here, we characterise uterine trNK longitudinally during pregnancy by single cell RNA sequencing find the combined expression pattern 4-1BB CD55 defines three distinct stages in mice....
Abstract Silkworm pupae oil derived from reeling waste is a rich source of α-linolenic acid (ALA), which has multipal applications. ALAs were added in sn -1, 3 positions triacylglycerol (TAG) to produce an APA-human milk fat analogues (APA-HMFAs, A: acid, P: palmitic acid). The optimum condition that tripalmitin free fatty acids 1:12 (mole ratio) at 65 °C for 48 h using lipase Lipozyme RM IM. Results show that, the major TAG species comprised APA-HMFAs ALA and contained 64.52% total...
Abstract The complete genome of Cordyceps militaris was sequenced using single-molecule real-time (SMRT) sequencing technology at a coverage over 300×. size 32.57 Mb, and 14 contigs ranging from 0.35 to 4.58 Mb with an N50 2.86 were assembled, including 4 telomeric sequences on both ends additional 8 either the 5′ or 3′ end. A methylome database constructed SMRT m4C m6A methylated nucleotides, many unknown modification types identified. major methylation motif is GA GGAG, GC CG/GC. In C ....
Abstract Respiratory Burst Oxidase Homologues (RBOHs) are involved in plant growth, development, and stress adaptation. How OsRBOHs affect root hair formation consequently nutrient acquisition drought resistance rice is not well understood. We knocked out six OsRBOH genes that were expressed roots identified OsRBOHE as the only one affecting formation. was strongly epidermis, hairs tiller buds. localised at plasma membrane. Knockout of decreased reactive oxygen species generation buds,...
Abstract Boron‐embedded heteroacenes (boraacenes) have attracted enormous interest in organic chemistry and materials science. However, extending the skeleton of boraacenes to higher acenes ( N ≥6) is synthetically challenging because their limited stability under ambient conditions. Herein, we report synthesis boron‐embedded heptacene DBH ) nonacene DBN as hitherto longest boraacenes. The former highly stable (even after 240 h tetrahydrofuran), while latter air‐sensitive with half‐life t...
Pathogenic Th17, featured by their production of pro-inflammatory cytokines, are considered as a key player in most autoimmune diseases. The transcriptome them is obviously distinct from that conventional regulatory Th17. However, chromatin accessibility the two Th17 groups have not been comprehensively compared yet. Here, we found chromatin-accessible regions(ChARs) significantly correlated with expression related genes, indicating they might engage regulation these genes. Indeed,...
The integration of Large Language Models (LLMs) into autonomous driving systems demonstrates strong common sense and reasoning abilities, effectively addressing the pitfalls purely data-driven methods. Current LLM-based agents require lengthy inference times face challenges in interacting with real-time environments. A key open question is whether we can leverage knowledge from LLMs to train an efficient robust Reinforcement Learning (RL) agent. This paper introduces RAPID, a novel...
Innate lymphoid cells (ILCs), as the innate counterpart of CD4 + T helper (Th) cells, play crucial roles in maintaining tissue homeostasis. While ILC subsets and their corresponding Th demonstrate significant similarities core programming related to effector function regulatory mechanisms, principal distinctions, given adaptive lymphocyte nature, remain largely unknown. In this study, we have employed an integrative analysis 294 bulk RNA-sequencing results across all subsets, using scRNA-seq...