A5073132844- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Photosynthetic Processes and Mechanisms
- Ubiquitin and proteasome pathways
- Bacteriophages and microbial interactions
- Viral Infections and Immunology Research
- Supramolecular Self-Assembly in Materials
- Legionella and Acanthamoeba research
- RNA modifications and cancer
- Chemical Synthesis and Analysis
- Biochemical and Molecular Research
- Plant Molecular Biology Research
- ATP Synthase and ATPases Research
- Nanoparticle-Based Drug Delivery
- Nanocomposite Films for Food Packaging
- Mitochondrial Function and Pathology
- interferon and immune responses
- biodegradable polymer synthesis and properties
- Pleistocene-Era Hominins and Archaeology
- Vibrio bacteria research studies
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Dendrimers and Hyperbranched Polymers
- Biochemical and Structural Characterization
Beijing University of Chemical Technology
2016-2025
Jinan University
2021-2025
Chengdu University of Traditional Chinese Medicine
2025
China Agricultural University
2025
Fujian Agriculture and Forestry University
2025
Hubei Academy of Agricultural Sciences
2024
Princess Margaret Cancer Centre
2020-2024
University Health Network
2020-2024
Kunming University of Science and Technology
2024
Lanzhou University
2021-2023
A fundamental strategy of eukaryotic antiviral immunity involves the cGAS enzyme, which synthesizes 2′,3′-cGAMP and activates effector STING. Diverse bacteria contain cGAS-like enzymes that produce cyclic oligonucleotides induce anti-phage activity, known as CBASS. However, this activity has only been demonstrated through heterologous expression. Whether harboring CBASS antagonize co-evolve with phages is unknown. Here, we identified an endogenous enzyme in Pseudomonas aeruginosa generates...
The successive emergences and accelerating spread of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages evolved resistance to some ongoing clinical therapeutics increase the risks associated with disease 2019 (COVID-19) pandemic. An urgent intervention for broadly effective therapies limit morbidity mortality COVID-19 future transmission events from SARS-related coronaviruses (SARSr-CoVs) is needed. Here, we isolate humanize an angiotensin-converting enzyme-2...
The screen-printing process of conductive ink can realize simple and large-scale manufacture micro/nano patterns for producing wearable electronic products. Herein, chitin nanocrystals (ChNCs) are used as a dispersant the preparation multiwalled carbon nanotube (MWCNT) with high viscosity uniformity by ultrasound treatment. ChNCs interact MWCNT in noncovalent ways, including π-π hydrophobic interactions. ChNCs/MWCNT (CCNT) does not aggregate even after standing 3 months maximum concentration...
A high-performance biodegradable plastic was made from a chitin KOH/urea solution. The solution transferred into hydrogel by cross-linking using epichlorohydrin and ethanol immersion, bioplastic finally prepared drying in mold at 40 °C. concentration positively impacts viscosity, crystallinity, smoothness. 4% exhibits high barrier properties, flame retardancy, high-temperature resistance, mechanical properties (tensile strength up to 107.1 MPa), soil degradation properties. can be completely...
Recently developed enzymes for the depolymerization of polyethylene terephthalate (PET) such as FAST-PETase and LCC-ICCG are inhibited by intermediate PET product mono(2-hydroxyethyl) (MHET). Consequently, conversion enzymatically into its constituent monomers terephthalic acid (TPA) ethylene glycol (EG) is inefficient. In this study, a protein scaffold (1TQH) corresponding to thermophilic carboxylesterase (Est30) was selected from structural database redesigned in silico. Among designs,...
We report on the preparation and drug delivery application of shell sheddable micelles based disulfide-linked star-shaped copolymer poly(ε-caprolactone) poly(ethyl glycol) (6sPCL-SS-PEG). Interestingly, exhibit high stability normally rapid destabilization under a reduction environment, eliciting GSH dependent cytotoxicity drug-loaded formulations tumor cells.
To solve the damage to environment and human body caused by organic solvent adhesives in utilization process, chitin nanocrystal (ChNC) suspension is explored as a strong anisotropic adhesive, which an eco-friendly water-based adhesive with high strength. ChNCs extracted from crab shells are rod-like nanoparticles aspect ratios, mainly employed reinforcing polymer nanocomposites biomedicine nanomaterials. ChNC sandwiched between substrates forms long-range ordered superstructure...
Chemo/photothermal combination therapy, a practical technology for cancer treatment, has drawn intensive interest from researchers. Designing nanoplatform with good biocompatibility, photothermal stability, and excellent target specificity is critical this technique. Here, halloysite nanotubes (HNTs), kind of natural clay mineral, were employed to construct multifunctional treating breast by promising chemo/photothermal therapy. Zeolitic imidazolate framework-8 (ZIF-8), metal–organic...
Flexible sensors with high sensitivity and reproducibility have critical applications in various industrial fields. However, current not yet been able to respond diverse signal changes the environment due their poor stability, weak conductivity, cost, time-consuming integration process. Herein, we used dip-coating technology prepare multifunctional rubber flexible which were based on Chinese ink carbon nanoparticle (ICN) water-based glue. The prepared ability sensitively detect temperature,...
Mechanosensitive (MS) channels are universal cellular membrane pores. Bacterial MS channels, as typified by channel of small conductance (MscS) from Escherichia coli ( Ec MscS), release osmolytes under hypoosmotic conditions. known to be ion selective different extents, but the underlying mechanism remains poorly understood. Here we identify an anion-selective MscS Thermoanaerobacter tengcongensis Tt MscS). The structure closely resembles that MscS, it lacks large cytoplasmic equatorial...
Legionella pneumophila promotes its survival and replication in phagocytes by actively modulating cellular processes using effectors injected into host cells Dot/Icm type IV secretion system. Many of these function to manipulate the ubiquitin network infected cells, thus contributing biogenesis Legionella-containing vacuole (LCV), which is permissive for bacterial replication. Among these, members SidE effector family (SidEs) catalyze ubiquitination functionally diverse proteins a mechanism...
Abstract CRISPR-Cas systems are prokaryotic adaptive immune and phages use anti-CRISPR proteins (Acrs) to counteract these systems. Here, we report the structures of AcrIF24 its complex with crRNA-guided surveillance (Csy) complex. The HTH motif can bind Acr promoter region repress transcription, suggesting role as an Aca gene in self-regulation. forms a homodimer further induces dimerization Csy Apart from blocking hybridization target DNA crRNA, also binding non-sequence-specific dsDNA...