A5100677651- Legionella and Acanthamoeba research
- RNA and protein synthesis mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- CRISPR and Genetic Engineering
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Viral Infections and Immunology Research
- Galectins and Cancer Biology
- Molecular Biology Techniques and Applications
- Sesame and Sesamin Research
- Free Radicals and Antioxidants
- Vibrio bacteria research studies
- Microtubule and mitosis dynamics
- Plant Virus Research Studies
- Signaling Pathways in Disease
- Moringa oleifera research and applications
- Erythrocyte Function and Pathophysiology
- Neurological Disease Mechanisms and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
Beijing University of Chemical Technology
2016-2023
Shandong Agricultural University
2023
Hunan Normal University
2017
Legionella pneumophila promotes its survival and replication in phagocytes by actively modulating cellular processes using effectors injected into host cells Dot/Icm type IV secretion system. Many of these function to manipulate the ubiquitin network infected cells, thus contributing biogenesis Legionella-containing vacuole (LCV), which is permissive for bacterial replication. Among these, members SidE effector family (SidEs) catalyze ubiquitination functionally diverse proteins a mechanism...
Protein ubiquitination is one of the most prevalent post-translational modifications, controlling virtually every process in eukaryotic cells. Recently, Legionella effector MavC was found to mediate a unique through transglutamination, linking ubiquitin (Ub) UBE2N UbGln40 that can be inhibited by another effector, Lpg2149. Here, we report structures MavC/UBE2N/Ub ternary complex, MavC/UBE2N-Ub (product) binary and MavC/Lpg2149 complex. During ubiquitination, loop containing modification site...
Biatractylolide, isolated from the ethyl acetate extract of Atractylodes macrocephala , has shown various pharmacological activities such as antitumor and antioxidant activities. In this work, we aim to study protective effect biatractylolide on glutamate‐induced rat adrenal pheochromocytoma cell (PC12) human bone marrow neuroblastoma line (SH‐SY5Y) injury preliminarily explore its mechanism. The results showed that glutamate was cytotoxic with an inhibitory concentration 50% (IC50) 8.5 mM...
CRISPR-Cas systems are bacterial adaptive immune systems, and phages counteract these using many approaches such as producing anti-CRISPR (Acr) proteins. Here, we report the structures of both AcrIF14 its complex with crRNA-guided surveillance (Csy) complex. Our study demonstrates that apart from interacting Csy to block hybridization target DNA crRNA, also endows ability interact non-sequence-specific dsDNA AcrIF9 does. Further structural studies Csy-AcrIF14-dsDNA biochemical uncover PAM...