A5100386701- Genomics and Phylogenetic Studies
- Plant Pathogens and Fungal Diseases
- Cytomegalovirus and herpesvirus research
- Plant Disease Resistance and Genetics
- Legionella and Acanthamoeba research
- Herpesvirus Infections and Treatments
- Mycorrhizal Fungi and Plant Interactions
- Identification and Quantification in Food
- Autophagy in Disease and Therapy
- Gut microbiota and health
- Plant Molecular Biology Research
- Microbial Natural Products and Biosynthesis
- Plant nutrient uptake and metabolism
- Mosquito-borne diseases and control
- Enzyme Catalysis and Immobilization
- Plant-Microbe Interactions and Immunity
- Immune Cell Function and Interaction
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Toxoplasma gondii Research Studies
- Immunotherapy and Immune Responses
- Insect symbiosis and bacterial influences
- Plant Gene Expression Analysis
- Retinoids in leukemia and cellular processes
- Plant Stress Responses and Tolerance
Heilongjiang Bayi Agricultural University
2023-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Purdue University West Lafayette
2021-2024
China Agricultural University
2015-2024
Nanjing University of Chinese Medicine
2023-2024
Nanjing Drum Tower Hospital
2023-2024
Sanya University
2023-2024
Nanjing Tech University
2024
Nanjing University
2024
Henan Agricultural University
2021-2023
Winter wheat and barley varieties require an extended exposure to low temperatures accelerate flowering (vernalization), whereas spring do not have this requirement. In study, we show that in these species, the vernalization gene VRN3 is linked completely a similar Arabidopsis FLOWERING LOCUS T (FT). FT induction leaves results transmissible signal promotes flowering. Transcript levels of orthologues, designated as HvFT TaFT, respectively, are significantly higher plants homozygous for...
Abstract The intracellular bacterial pathogen Legionella pneumophila modulates host cell functions by secreting multiple effectors with diverse biochemical activities. In particular, of the SidE family interfere protein ubiquitination in a process that involves production phosphoribosyl ubiquitin (PR-Ub). Here, we show effector LnaB converts PR-Ub into ADP-ribosylated ubiquitin, which is further processed to ADP-ribose and functional (ADP-ribosyl)hydrolase MavL, thus maintaining homeostasis...
Alphaherpesviruses that establish persistent infections rely partly on their ability to evade host antiviral responses, notably the type I interferon (IFN) response. However, mechanisms employed by alphaherpesviruses avoid this response are not well understood. Pseudorabies virus (PRV) is an economically important pathogen and a useful model system for studying alphaherpesvirus biology. To identify PRV proteins antagonize IFN signaling, we performed screen using IFN-stimulated element...
Abstract ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being major family this category. The pathogen Legionella pneumophila mediates atypical ubiquitination host targets using the SidE effector process that involves ubiquitin on arginine 42 as an obligatory step. Here, we show MavL regulates pathway by reversing ADP-ribosylation, likely to minimize potential...
The anti-inflammatory and immunomodulatory properties of mesenchymal stem cells (MSCs) have been proposed to be involved in some autoimmune diseases successfully tested patients mice. But their contribution psoriasis the underlying mechanisms remains elusive. Here, we explored feasibility using human umbilical cord-derived MSC (hUC-MSC) infusion as a therapeutic approach an imiquimod- (IMQ-) induced mouse model. were found significantly reduce severity development psoriasis, inhibit...
Abstract Background ALK is the key gene controlling rice gelatinization temperature (GT), which closely associated with eating and cooking quality (ECQ) in ( Oryza sativa L.). To date, at least three alleles are thought to be responsible for diversity of GT among cultivars. The c /SSIIa i allele high activity soluble starch synthase IIa (SSIIa) controls GT, but accurate functional difference between a b alleles, both low not clearly elucidated. Thus, we generated near-isogenic lines (NILs)...
Legionella pneumophila promotes its survival and replication in phagocytes by actively modulating cellular processes using effectors injected into host cells Dot/Icm type IV secretion system. Many of these function to manipulate the ubiquitin network infected cells, thus contributing biogenesis Legionella-containing vacuole (LCV), which is permissive for bacterial replication. Among these, members SidE effector family (SidEs) catalyze ubiquitination functionally diverse proteins a mechanism...
Abstract Shigella flexneri is a Gram-negative bacterium causing severe bloody dysentery. Its pathogenesis largely dictated by plasmid-encoded type III secretion system (T3SS) and its associated effectors. Among these, the effector OspG has been shown to bind ubiquitin conjugation machinery (E2~Ub) activate kinase activity. However, cellular targets of remain elusive despite years extensive efforts. Here we show unbiased phosphoproteomics that major target CAND1, regulatory protein...
Bovine viral diarrhea virus (BVDV) is prevalent worldwide and causes significant economic losses. Gut microbiota a large microbial community has variety of biological functions. However, whether there correlation between gut BVDV infection what kind relation them have not been reported. Here, we found that composition changed in normal mice after infecting with BVDV, but mainly the low abundance microbe was affected. Interestingly, significantly reduced diversity its microbiota-dysbiosis...
Legionella pneumophila strains harboring wild-type rpsL such as Lp02 WT cannot replicate in mouse bone marrow-derived macrophages (BMDMs) due to induction of extensive lysosome damage and apoptosis. The bacterial factor directly responsible for inducing cell death the host involved initiating signaling cascade that leads remain unknown. Similarly, factors may alleviate induced by these have not yet been investigated. Using a genome-wide CRISPR/Cas9 screening, we identified Hmg20a Nol9...
Promyelocytic leukemia protein (PML) nuclear bodies (NBs), which are sub-nuclear structures, involved in a variety of important cellular functions. PML-NBs assembled by PML isoforms, and contact between small ubiquitin-like modifiers (SUMOs) with the SUMO interaction motif (SIM) critically this process. isoforms contain common N-terminal region variable C-terminus. However, contribution C-terminal regions to PML-NB formation remains poorly defined. Here, using high-resolution microscopy, we...
Abstract In Arabidopsis, the photoreceptors phytochrome B (PhyB) and UV-B resistance 8 (UVR8) mediate light responses that play a major role in regulating photomorphogenic hypocotyl growth, but how they crosstalk to coordinate this process is not well understood. Here we report map-based cloning functional characterization of an ultraviolet (UV)-B-insensitive, long-hypocotyl mutant, lh1, wild-type-like lh2, cucumber (Cucumis sativus), which show defective CsPhyB GA oxidase2 (CsGA20ox-2), key...
The presence of deoxynivalenol (DON), one the most frequently occurring mycotoxin, in food and feed has been considered a risk factor to both human animal health. Molecular mechanisms that regulate DON effects tissues are still poorly understood. However, recent evidence suggests nuclear erythroid 2-like 2 (Nrf2) may be major target during mycotoxin-induced intestinal barrier dysfunction. Although quercetin, plant-derived flavonoid, is known induce activation Nrf2 signaling pathway, its...
Abstract Purpose Previous studies have suggested that obesity defined by body mass index(BMI) is a protective factor for bone mineral density(BMD), but overlooked the potential influence of different types obesity. This study aims to evaluate correlation between abdominal index A Body Shape Index(ABSI) and adolescent density, analyze relationship metabolism. Methods total 1557 participants were included in NHANES from 2007 2018. Calculate ABSI using specific formula takes into account waist...
Objective Sjögren’s disease (SjD) is an autoimmune characterised by inflammatory destruction of exocrine glands. Patients with autoantibodies to Ro/SSA (SjD Ro+ ) exhibit more severe disease. Long non-coding RNAs (lncRNAs) are a functionally diverse class non-protein-coding whose role in pathology has not been well characterised. Methods Whole blood RNA-sequencing (RNA-seq) was performed on SjD cases (n=23 negative Ro− ); n=27 positive and healthy controls (HCs; n=27). Bioinformatics pathway...
Phlorizin (PHZ) is one of the main pharmacologically active ingredients in
Preeclampsia (PE) is an important topic in obstetrics. In this study, we used weighted gene co-expression network analysis (WGCNA) to screen the key modules related immune cell infiltration and identify hub genes for molecular subtyping of PE. We first downloaded a set PE transcriptional data (GSE75010; 157 samples: 80 77 non-PE) from GEO database. then analyzed samples non-PE screened cells with differences such infiltration. Next, immune-related database expression profile genes. Then,...
Neural tube defects are the most severe congenital malformations that result from failure of neural closure during early embryonic development, and underlying molecular mechanisms remain elusive. Retinoic acid, an active derivative vitamin A, is critical for system retinoic acid receptor (RAR) signalling malfunctions have been observed in human defects. However, acid-retinoic regulation not fully understood. The mRNA expression RARs retinoid X receptors different defect phenotypes, including...