A5055462313- Glycosylation and Glycoproteins Research
- Malaria Research and Control
- Mosquito-borne diseases and control
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- PARP inhibition in cancer therapy
- SARS-CoV-2 detection and testing
- Adversarial Robustness in Machine Learning
- Hand Gesture Recognition Systems
- SARS-CoV-2 and COVID-19 Research
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Multimodal Machine Learning Applications
- Robot Manipulation and Learning
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Galectins and Cancer Biology
- Bacteriophages and microbial interactions
- Human Pose and Action Recognition
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- Microbial Inactivation Methods
California Institute of Technology
2024
Peking University
2020-2023
University of Electronic Science and Technology of China
2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022
Center for Life Sciences
2020-2021
Institute of Molecular Medicine
2020
We present HOI4D, a large-scale 4D egocentric dataset with rich annotations, to catalyze the research of category-level human-object interaction. HOI4D consists 2.4M RGB-D video frames over 4000 sequences col-lected by 9 participants interacting 800 different ob-ject instances from 16 categories 610 indoor rooms. Frame-wise annotations for panoptic segmentation, motion 3D hand pose, object pose and action have also been provided, together reconstructed meshes scene point clouds. With we...
The successive emergences and accelerating spread of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages evolved resistance to some ongoing clinical therapeutics increase the risks associated with disease 2019 (COVID-19) pandemic. An urgent intervention for broadly effective therapies limit morbidity mortality COVID-19 future transmission events from SARS-related coronaviruses (SARSr-CoVs) is needed. Here, we isolate humanize an angiotensin-converting enzyme-2...
Abstract Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as first line of humoral defense against infection and potently activates complement pathway to facilitate P. clearance. A number proteins bind IgM, leading immune evasion disease. However, underlying molecular mechanisms remain unknown. Here, using high-resolution cryo-electron microscopy, we delineate how VAR2CSA, TM284VAR1, DBLMSP, DBLMSP2 target IgM. Each protein binds IgM a different...
Generalizable object manipulation skills are critical for intelligent and multi-functional robots to work in real-world complex scenes. Despite the recent progress reinforcement learning, it is still very challenging learn a generalizable policy that can handle category of geometrically diverse articulated objects. In this work, we tackle category-level learning problem via imitation task-agnostic manner, where assume no handcrafted dense rewards but only terminal reward. Given novel...
Cardiometabolic diseases, including diabetes and its cardiovascular complications, are the global leading causes of death, highlighting a major unmet medical need. Over past decade, mitsugumin 53 (MG53), also called TRIM72, has emerged as powerful agent for myocardial membrane repair cardioprotection, but therapeutic value is complicated by E3 ligase activity, which mediates metabolic disorders. Here, we show that an ligase-dead mutant, MG53-C14A, retains cardioprotective function without...
ABSTRACT A major challenge in the fields of biological imaging and synthetic biology is noninvasively visualizing functions natural engineered cells inside opaque samples such as living animals. One promising technology that addresses this limitation ultrasound (US), with its penetration depth several cm spatial resolution on order 100 µm. 1 Within past decade, reporter genes for US have been introduced 2,3 4,5 to link cellular signals via heterologous expression commensal bacteria mammalian...
Abstract Secretory Immunoglobulin A (SIgA) is the most abundant antibody at mucosal surface. SIgA possesses two additional subunits besides IgA: joining chain (J-chain) and secretory component (SC). SC ectodomain of polymeric immunoglobulin receptor (pIgR), which functions to transport IgA mucosa. The underlying mechanism how J-chain pIgR/SC facilitates assembly secretion remains be understood. During infection Streptococcus pneumoniae , a pneumococcal adhesin SpsA hijacks unliganded evade...
Abstract Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as first line of humoral defense against infection and potently activates complement pathway to facilitate P. clearance. A number proteins hijack IgM, leading immune evasion disease. However, underlying molecular mechanisms remain unknown. Here, using high-resolution cryo-electron microscopy, we delineate how VAR2CSA, TM284VAR1, DBLMSP, DBLMSP2 target IgM. Each protein binds IgM a different...
Introduction: MG53, essential for cardiac ischemic protection, negatively regulates insulin receptor (IR) to trigger globular metabolic dysfunction, which makes up a big obstacle its clinical use. In vitro evidence shows that C14A site of MG53 might be promising target both abolish regulation on IR and keep as much protective function. However, in vivo effect mutation is urgent explored. Results: Here, we found knock-in mice exerted relieved resistance, blood glucose, phenotype high fat...
Abstract Immunoglobulin M (IgM) is the first antibody to emerge during embryonic development and humoral immune response 1 . IgM can exist in several distinct forms, including monomeric, membrane-bound (mIgM) within B-cell receptor (BCR) complex, pentameric hexameric serum, secretory on mucosal surface. FcμR/Toso/Faim3, only IgM-specific mammals, recognizes different forms of regulate diverse responses 2-4 However, underlying molecular mechanisms remain unknown. Here we delineate structural...
Abstract Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as first line of humoral defense against infection and potently activates complement pathway to facilitate P. clearance. A number proteins hijack IgM, leading immune evasion disease. However, underlying molecular mechanisms remain unknown. Here, using high-resolution cryo-electron microscopy, we delineate how VAR2CSA, TM284VAR1, DBLMSP, DBLMSP2 target IgM. Each protein binds IgM a different...