A5010079041- HER2/EGFR in Cancer Research
- Cosmology and Gravitation Theories
- Black Holes and Theoretical Physics
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Galaxies: Formation, Evolution, Phenomena
- Cytokine Signaling Pathways and Interactions
- Cell death mechanisms and regulation
- Advanced Differential Geometry Research
- PI3K/AKT/mTOR signaling in cancer
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Advanced Thermodynamics and Statistical Mechanics
- Geophysics and Gravity Measurements
- High-Energy Particle Collisions Research
- Noncommutative and Quantum Gravity Theories
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Quantum Mechanics and Applications
- Planetary Science and Exploration
- Solar and Space Plasma Dynamics
- Toxin Mechanisms and Immunotoxins
- Quantum Mechanics and Non-Hermitian Physics
- Quantum chaos and dynamical systems
- Pulsars and Gravitational Waves Research
Jishou University
2020-2024
Utrecht University
2015-2017
Duke Medical Center
2005-2016
Tianjin University
2015
National Institute of Metrology
2015
Hunan Normal University
2012
George Mason University
2011
Duke University
2010-2011
Xiamen University
2010-2011
Cancer Research Center
2011
The development of acquired resistance to ErbB2 tyrosine kinase inhibitors limits the clinical efficacy this class cancer therapeutics. Little is known about mechanism(s) these agents. Here we establish a model N-{3-chloro-4-[(3-fluorobenzyl) oxy]phenyl}-6-[5-({[2 (methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (lapatinib), an inhibitor and ErbB1 kinases by chronically exposing lapatinib-sensitive ErbB2-overexpressing breast cells lapatinib, simulating clinic where lapatinib...
This was a pilot study to assess the biologic effects of lapatinib on various tumor growth/survival pathways in patients with advanced ErbB1 and/or ErbB2-overexpressing solid malignancies.Heavily pretreated metastatic cancers overexpressing ErbB2 expressing were randomly assigned one five dose cohorts (GW572016) administered orally once daily continuously. The growth and survival assessed biopsies obtained before after 21 days therapy. Clinical response determined at 8 weeks.Sequential from...
Abstract Trastuzumab antitumor activity in ErbB2-overexpressing breast cancers seems to be dependent upon the presence of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a that dampens phosphatidylinositol 3-kinase-Akt signaling. Consequently, PTEN deficiency, which occurs 50% cancers, predicts for resistance trastuzumab monotherapy. Here, we show lapatinib, small-molecule inhibitor ErbB1 ErbB2 tyrosine kinases, exerts its PTEN-independent manner. Steady-state...
Abstract Introduction The human epidermal growth factor receptor 2 ( HER2 ) tyrosine kinase (RTK) oncogene is an attractive therapeutic target for the treatment of HER2-addicted tumors. Although lapatinib, FDA-approved small-molecule and (EGFR) inhibitor (TKI), represents a significant advancement in + breast cancers, responses to lapatinib have not been durable. Consequently, elucidation mechanisms acquired resistance HER-directed therapies critical importance. Methods Using functional...
Abstract In breast cancer, overexpression of ErbB2 or aberrant regulation survivin, a member the inhibitor apoptosis family, is associated with resistance to chemo/hormone therapy and predicts for poor clinical outcome. A functional link between two predictive factors has not been previously shown. Here, using genetic pharmacologic approaches block signaling, we show that regulates survivin protein expression in ErbB2-overexpressing cancer cells. Selective knockdown small interfering RNA...
Abstract The widespread clinical use of therapies targeting the ErbB2 receptor tyrosine kinase oncogene represents a significant advance in breast cancer treatment. However, development therapeutic resistance dilemma limiting their efficacy, particularly small-molecule inhibitors that block autophosphorylation and activation. Here, we show lapatinib (GW572016), highly selective, inhibitor epidermal growth factor kinases, which was recently approved for treatment advanced-stage ErbB2+ cancer,...
The strong decays of charm-strange baryons up to $N=2$ shell are studied in a chiral quark model. theoretical predictions for the well-determined baryons, ${\ensuremath{\Xi}}_{c}^{*}(2645)$, ${\ensuremath{\Xi}}_{c}(2790)$, and ${\ensuremath{\Xi}}_{c}(2815)$, good agreement with experimental data. This model is also extended analyze other newly observed ${\ensuremath{\Xi}}_{c}(2930)$, ${\ensuremath{\Xi}}_{c}(2980)$, ${\ensuremath{\Xi}}_{c}(3055)$, ${\ensuremath{\Xi}}_{c}(3080)$,...
A bstract In this work, we have systematically investigated the Krylov complexity of curvature perturbation for modified dispersion relation in inflation, using algorithm closed system and open system. Since many quantum gravitational frameworks could lead to kind relation, our analysis be applied string cosmology, loop gravity, e.t.c . Following Lanczos algorithm, find very early universe is an infinite, many-body, maximal chaotic Our numerics shows that coefficient Lyapunov index standard...
ErbB2 tyrosine kinase inhibitors (TKI) block autophosphorylation and activation of the full-length transmembrane receptor (p185(ErbB2)). In addition to p185(ErbB2), truncated forms exist in breast cancer cell lines clinical tumors. The contribution these forms, specifically those expressed tumor nuclei, development therapeutic resistance TKIs has not been previously shown. Here, we show that expression a 95-kDa phosphorylated form ErbB2, herein referred as p95L (lapatinib-induced p95) was...
Photo-activation of psoralen with UVA irradiation, referred to as PUVA, is used in the treatment proliferative skin disorders. The anti-proliferative effects PUVA have been largely attributed intercalation DNA, which upon UV treatment, triggers formation interstrand DNA crosslinks (ICL) that inhibit transcription and replication. Here, we show exerts antitumor models human breast cancer overexpress ErbB2 receptor tyrosine kinase oncogene, through a new mechanism. Independent ICL formation,...
This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of solid cancer. utilizes psoralen, potent anti-cancer therapeutic with current application to proliferative disease and extracorporeal photopheresis (ECP) cutaneous T Cell Lymphoma. An immunogenic role light-activated psoralen has been reported, contributing long-term clinical responses. therapies have to-date limited superficial or scenarios due requirement activation by UVA light,...
We propose gravitational microlensing as a way of testing the emergent gravity theory recently proposed by Eric Verlinde [1]. consider two limiting cases: dark mass maximally anisotropic pressures (Case I) and isotropic II). Our analysis perihelion advancement planet shows that only Case I yields viable theory. In this case metric outside star M⁎ can be modeled point-like global monopole whose is deficit angle Δ=(2GH0M⁎)/(3c3), where H0 Hubble rate G Newton constant. This used to test since...
We systematically investigate the microlensing effect of a charged spherically symmetric wormhole, where light source is remote from throat. Remarkably, there will be at most three images by considering charge part. study all situations including images, two and one image, respectively. The numerical result shows that range total magnification ${10}^{5}$ to ${10}^{\ensuremath{-}2}$ depending on various metrics. In case maximal values (a peak gentle peak) when contribution via mass much less...
In this paper, we investigate the primordial perturbations of inflation model induced from multi-field mimetic gravity, where there are two field during inflation, and thus both adiabatic isocurvature perturbation modes generated. We show that although it is true original mode loses kinetic term due to constraint equation, by applying curvaton mechanism one viewed as field, can actually be transferred at end inflation. Detailed calculations performed for inflationary consequent...
Complexity will be more and essential in high-energy physics. It is naturally extended into the very early universe. Considering universe as a quantum chaotic system, curvature perturbation of scalar field identified with two-mode squeezed state. By solving Schrödinger equation, one can obtain numerical solutions angle parameter squeezing parameter. The solution mainly determines evolution complexity. Our numeric indicates that complexity modified dispersion relation have non-linear pattern...
With its unique structure, the Akiyama probe is a type of tuning fork atomic force microscope probe. The long, soft cantilever makes it possible to measure samples in tapping mode. In this article, some characteristics at second eigenmode are revealed by use finite element analysis (FEA) and experiments standard atmosphere. Although signal-to-noise ratio environment not good enough, 2 nm resolution 0.09 Hz/nm sensitivity prove that can be used under FM non-contact mode or low amplitude mode,...
Inspired by \cite{Jiang:2018uce}, we propose a similar curvaton mechanism whose realization occurs in preheating process, which the effective mass is running (its potential consists of coupling part and exponential contribution subdominant comparing to part). The production contains cases narrow resonance broad resonances criteria comes via spectral index curvaton. Since inflationary chaotic inflation (quadratic potential), it could smoothly transit into process. Once entropy perturbation...
Complexity will be more and essential in high-energy physics. It is naturally extended into the very early universe. Considering universe as a quantum chaotic system, curvature perturbation of scalar field identified with two-mode squeezed state. By solving Schr$\ddot{o}$dinger equation, one can obtain numerical solutions angle parameter squeezing parameter. The solution mainly determines evolution complexity. Our numeric indicates that complexity modified dispersion relation have non-linear...
We revise the non-Gaussianity of canonical curvaton scenario with a generalized $\ensuremath{\delta}N$ formalism, in which it can handle generic potentials. In various models, energy density is dominant different periods including secondary inflation curvaton, matter domination, and radiation domination. Our method unify to deal these since nonlinearity parameter ${f}_{\mathrm{NL}}$ associated function equation state $w$. first investigate most simple scenario, namely, chaotic quadratic...
We study the $R^p$ inflationary model of [Muller:1989rp] for $p>2$ using result Ref. [Motohashi:2014tra]. After reproducing observable quantities: power spectral index $n_s$, its corresponding running $\alpha=\frac{dn_s}{d\ln(k)}$ and tensor to scalar ration $r$ in terms e-folding number $N$ $p$, we show that inflation is still alive as $p$ from $2$ $2.02$. In this range, our calculation confirms $n_s$ agree with observations $\alpha$ order $10^{-4}$ which needs more precise observational...