A5001099948- Nanoplatforms for cancer theranostics
- Ginseng Biological Effects and Applications
- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Pharmacological Effects of Natural Compounds
- Advanced Fluorescence Microscopy Techniques
- Photodynamic Therapy Research Studies
- Natural product bioactivities and synthesis
- Advanced Biosensing Techniques and Applications
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- bioluminescence and chemiluminescence research
- Adenosine and Purinergic Signaling
- Drug Transport and Resistance Mechanisms
- Skin Protection and Aging
- Advanced biosensing and bioanalysis techniques
- Silk-based biomaterials and applications
- Text and Document Classification Technologies
- Toxin Mechanisms and Immunotoxins
- Tattoo and Body Piercing Complications
- Digital Radiography and Breast Imaging
- Genomics, phytochemicals, and oxidative stress
- Pain Management and Opioid Use
Dartmouth College
2019-2023
The University of Texas Southwestern Medical Center
2023
Duke Medical Center
2016-2017
Duke University
2017
Duke University Hospital
2017
Lanzhou University of Technology
2016
Simcere Pharmaceutical (China)
2010
China Pharmaceutical University
2008-2009
The advent of cone beam computed tomography-based online adaptive radiation therapy (oART) has dramatically reduced the barriers adaptation. We present first prospective oART experience data in head and neck cancers (HNC).Patients with HNC receiving definitive standard fractionation (chemo)radiation who underwent at least 1 session were enrolled a registry study. frequency adaptations was discretion treating physician. Physicians given option delivering 2 plans during adaptation: original...
This article was intended to improve the absorption of ginsenoside Rg1 and Rb1 Panax notoginseng saponins (PNS).PNS-Phospholipid complex a lipid-based formulation by dissolving in medium chain fattyglycerides were prepared, their oral relative bioavailability determined rats compared with an aqueous solution PNS for each component.The study gave evidence that phospholipids could combine two active constitutes form PNS-phospholipid complex. The efficiently increased solubility hydrophilic...
This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of solid cancer. utilizes psoralen, potent anti-cancer therapeutic with current application to proliferative disease and extracorporeal photopheresis (ECP) cutaneous T Cell Lymphoma. An immunogenic role light-activated psoralen has been reported, contributing long-term clinical responses. therapies have to-date limited superficial or scenarios due requirement activation by UVA light,...
Whole-animal fluorescence cryo-imaging is an established technique that enables visualization of the biodistribution labeled drugs, contrast agents, functional reporters and cells in detail. However, many tissues produce endogenous autofluorescence, which can confound interpretation volumes. We describe a multi-channel, hyperspectral system acquires densely-sampled spectra at each pixel 3-dimensional stack. This information use spectral unmixing to isolate fluorophore-of-interest from...
Our previous study suggested that adrenaline (epinephrine) could be an effective absorption enhancer for ginsenoside Rg1 (Rg1). This focused on the transport mechanism of and role sodium-dependent glucose co-transporter 1 in regulation uptake after exposure to adrenaline.Caco-2 cells were used as in-vitro model assess Rg1. Also effect D-glucose adrenaline-induced was investigated vivo rats.Results showed temperature-dependent. The from basolateral side apical significantly lower compared...
The purpose of this research was to evaluate the ability adrenaline (epinephrine) stimulate uptake ginsenoside Rg1 (Rg1) by Caco-2 cells.Rg1 measured using cell monolayers. medium with at different concentrations added each well and incubated for time intervals. Adrenergic antagonists such as phentolamine propranolol were incubation investigate their effects on uptake. concentration in monolayers determined high-performance liquid chromatography. Transport across cells also studied an oral...
Objectives The purpose of this research was to evaluate the ability adrenaline (epinephrine) stimulate uptake ginsenoside Rg1 (Rg1) by Caco-2 cells. Methods measured using cell monolayers. medium with at different concentrations added each well and incubated for time intervals. Adrenergic antagonists such as phentolamine propranolol were incubation investigate their effects on uptake. concentration in monolayers determined high-performance liquid chromato-graphy. Transport across cells also...
This study demonstrates remote imaging for in vivo detection of radiation-induced tumor microstructural changes by tracking the diffusive spread injected intratumor UV excited tattoo ink using Cherenkov-excited luminescence (CELI). Micro-liter quantities luminescent with absorption and visible emission were at a depth 2 mm into mouse tumors prior to receiving high dose treatment radiation. X-rays from clinical linear accelerator used excite phosphorescent compounds within through Cherenkov...
Immuno-oncological treatment strategies that target abnormal receptor profiles of tumors are an increasingly important feature cancer therapy. Yet, assessing availability (RA) and drug-target engagement, determinants therapeutic efficacy, is challenging with current imaging strategies, largely due to the complex nonspecific uptake behavior agents in tumors. Herein, we evaluate whether a quantitative noninvasive approach designed compensate for uptake, MRI-coupled paired-agent fluorescence...
Purpose Rapid, intra-operative identification of tumor tissue in the margins excised specimens has become an important focus pursuit reducing re-excision rates, especially for breast conserving surgery. Dual-probe difference specimen imaging (DDSI) is emerging approach that uses uptake/clearance kinetics between a pair fluorescently-labeled stains, one targeted to biomarker-of-interest and other untargeted isotype, reveal receptor-specific images specimen. Previous studies using antibodies...
Abstract Objectives Our previous study suggested that adrenaline (epinephrine) could be an effective absorption enhancer for ginsenoside Rg1 (Rg1). This focused on the transport mechanism of and role sodium-dependent glucose co-transporter 1 in regulation uptake after exposure to adrenaline. Methods Caco-2 cells were used as in-vitro model assess Rg1. Also effect D-glucose adrenaline-induced was investigated vivo rats. Key findings Results showed temperature-dependent. The from basolateral...
First, this article analyzes the Application layer Distributed Denial of Service(DDoS)'s attack principle and characteristic.According to difference between normal users' browsing patterns abnormal ones, user sessions are extracted from web logs users similarities different calculated .Because traditional K-mean Clustering algorithm is easy fail into local optimal, Particle Swarm Optimization used generate a detecting model.This model can been detect whether undetermined DDoS attacks or...
Purpose: This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of cancer. utilizes psoralen, potent anti-cancer therapeutic with immunogenic potential. therapies have been limited due to requirement psoralen activation by UVA light. solves this challenge activating UV light emitted from novel non-tethered phosphors (co-incubated psoralen) that absorb x-rays and reradiate (phosphoresce) at wavelengths. Methods: The efficacy was evaluated in...
Angiogenesis inhibiting cancer therapy has become a standard treatment for many types. The ability to examine the effects of these drugs in tumors noninvasively could help assess efficacy early course or identify optimal times introduce other combinatorial treatments. Herein, we whether paired agent MRI-coupled fluorescence tomography approach can be used monitor anti-angiogenesis therapy. Using small animal models bearing orthotopic glioma xenografts, demonstrate noninvasive quantification...
Optical tomography is often coupled with high resolution imaging modality like MRI to provide functional information associated specific anatomical structure noninvasively. MRI-coupled paired agent fluorescence molecular (MRI-PAFT) a hybrid capable of noninvasively quantifying drug-target engagement in vivo utilizing targeted and an untargeted agent. This study compares the uptake kinetics contrast agents tumor normal tissue, demonstrates potential kinetic quantify receptor concentration...
Characterizing an administered drug's pathway from initial systemic uptake, to targeted tissue accumulation, and the eventual excretion route is important component of clinical translation. For mapping such pharmacokinetic behaviors in a biologically-relevant system, fluorescently-tagged drugs are commonly examined preclinical animal models. Broadband fluorescence cryo-imaging offers high-resolution, whole-animal technique for recovering biodistributions, although agent-specificity remains...
Abstract Purpose The ability to noninvasively quantify receptor availability (RA) in solid tumors is an aspirational goal of molecular imaging, often challenged by the influence non-specific accumulation contrast agent. Paired-agent imaging (PAI) techniques aim compensate for this effect kinetics a targeted agent and untargeted isotype, simultaneously, comparing two agents estimate RA. This usually accomplished using spectrally distinct fluorescent agents, limiting technique superficial...
In "Internet+" era, how to real-time monitoring and build effective pre-warning systems of the network public opinion crisis has become a required courses for government departments enterprises.This paper sufficiently considers development，changes in laws characteristics o-pinion crisis, establishes index system with 7 indexes opinion.Because final redundancy lack data, building Pre-Warning model based on PCA SVM, using PSO optimize parameters SVM.Experiment shows PCA-PSO-SVM is feasible.
Abstract Background Opioid use disorder (OUD) affects more than 14 million Americans and poses a high risk of relapse, overdose, death. Current treatments are not tailored to individual needs do monitor the effectiveness medication. We propose novel method measure occupancy mu opioid receptors (MOR), which key targets for pharmacotherapy, in peripheral tissues with MOR density. developed fluorescent peptide agonist that binds can be detected by non-invasive point-of-care techniques. present...