A5100417611- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Fungal and yeast genetics research
- Nail Diseases and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant Pathogens and Fungal Diseases
- Peptidase Inhibition and Analysis
- Fungal Biology and Applications
- Infectious Diseases and Mycology
- Microbial Natural Products and Biosynthesis
- Plant-Microbe Interactions and Immunity
- Dermatology and Skin Diseases
- Reproductive tract infections research
- Antimicrobial Resistance in Staphylococcus
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Bacterial biofilms and quorum sensing
- Photodynamic Therapy Research Studies
- Probiotics and Fermented Foods
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Flavonoids in Medical Research
Georgetown University
2016-2025
Georgetown University Medical Center
2016-2025
Chinese PLA General Hospital
2024-2025
Nanjing University
2025
Chengdu University of Traditional Chinese Medicine
2025
Chongqing Normal University
2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Tianjin University of Science and Technology
2023
National Institute for Communicable Disease Control and Prevention
2023
Beijing Academy of Artificial Intelligence
2023
An asymmetric wound dressing acts as a skin-like structure serves protective barrier between and its surroundings. It allows for the absorption of tissue fluids release active substances at site, thus speeding up healing process. However, production such dressings requires acquisition specialized tools, expensive polymers, solvents that contain harmful byproducts. In this study, an bacterial cellulose (ABC) using starch porogen has been developed. By incorporating silver-metal organic...
As chronic inflammatory conditions driven by immune dysregulation are influenced genetics and environment factors, psoriasis atopic dermatitis (AD) have traditionally been considered to be distinct diseases characterized different T cell responses. Psoriasis, associated with type 17 helper (Th17)-mediated inflammation, presents as well-defined scaly plaques minimal pruritus. AD, primarily linked Th2-mediated poorly defined erythema, dry skin, intense itching. However, AD may overlap or...
ABSTRACT Ssk1p of Candida albicans is a putative response regulator protein the Hog1 two-component signal transduction system. In Saccharomyces cerevisiae , phosphorylation state determines whether genes that promote adaptation cells to osmotic stress are activated. We have previously shown C. SSK1 does not complement ssk1 mutant S. and sensitive sorbitol. this study, we show several oxidants, including hydrogen peroxide, t -butyl hydroperoxide, menadione, potassium superoxide when each...
Using a Tn7 transposon library of Candida albicans, we have identified mutant that exhibited sensitivity in drop plate assays to oxidants such as menadione and hydrogen peroxide. To verify the role mutated gene stress adaptation, null mutants were constructed phenotypically characterized. Because its apparent functions growth oxidant named GOA1. Goa1p appears be unique CTG subclade Saccharomycotina, including C. albicans. Mutants albicans lacking goa1 (strain GOA31) more sensitive 6 mM...
We have previously shown that deletion of GOA1 (growth and oxidant adaptation) Candida albicans results in a loss mitochondrial membrane potential, ATP synthesis, increased sensitivity to oxidants killing by human neutrophils, avirulence systemic model candidiasis. established translocation Goa1p mitochondria occurred during peroxide stress. In this report, we show the goa1Δ (GOA31), compared wild type (WT) gene-reconstituted (GOA32) strain, exhibits inhibitors classical respiratory chain...
// Guanzhao Liang 1 , Musang Liu Qiong Wang Yongnian Shen Huan Mei Dongmei Li 1, 2 Weida Department of Mycology, Institute Dermatology, Chinese Academy Medical Sciences and Peking Union College, Nanjing, China Georgetown University Center, Washington, DC, USA Correspondence to: Liu, email: liumyco@hotmail.com Keywords: itraconazole, melanoma, hedgehog, Wnt, mTOR Received: July 23, 2016 Accepted: January 06, 2017 Published: February 14, ABSTRACT Malignant melanoma is the deadliest form all...
The Beckmann rearrangement of cyclohexanone oxime to afford caprolactam in a novel caprolactam-based Brønsted acidic ionic liquid as catalyst and reaction medium proceeded with high conversion selectivity at 100 °C. occurrence the such IL was also confirmed situ FT-Raman observation. key point is that product one component liquid, dynamic exchange between resulting from expected. Therefore, strong chemical combination greatly decreased desired solid recovered through extraction organic...
Abstract Objectives The histone deacetylase (HDAC) has recently been linked to the morphogenesis and virulence of yeast. However, effects HDAC on antifungal susceptibility are not well understood. We sought characterize action deacetylation azole resistance in Candida albicans its possible mechanism action. Methods A total 40 C. strains were studied. Azole with or without trichostatin (TSA) was determined according CLSI microdilution method. null mutants HDA1 RPD3 (genes targeted by TSA)...
Undecylenic acid can effectively control skin fungal infection, but the mechanism of its inhibition is unclear. Hyphal growth Candida albicans (C. albicans) and biofilm formation have been well recognized as important virulence factors for initiation infection late development disseminated infection. In this study, we seek to investigate antifungal mechanisms undecylenic by evaluating C. during formation. We found that inhibits with optimal concentration above 3 mM. presence compound,...
Pathogenic mycobacteria pose a sustained threat to global human health. Recently, cytochrome bcc complexes have gained interest as targets for antibiotic drug development. However, there is currently no structural information the complex from these pathogenic mycobacteria. Here, we report structures of Mycobacterium tuberculosis alone (2.68 Å resolution) and in with clinical candidates Q203 (2.67 TB47 (2.93 determined by single-particle cryo-electron microscopy. M. forms dimeric assembly...
Recurrent vulvovaginal candidiasis (RVVC) and are one of the most common gynecological infections, primarily caused by Candida species. Although risk factors RVVC VVC have been identified in many studies, antifungal immunological mechanisms still not fully understood. We performed a 1-year prospective study local hospital to monitor 98 patients clinically diagnosed with infection. The results showed that 20.41% (20/98) RVVC, 79.59% (78/98) VVC. C. albicans accounts for 90% 96.1% all strains...
ABSTRACT Azole drugs are the main therapeutic for invasive fungal infections. However, azole-resistant strains appear repeatedly in environment, posing a major threat to human health. Several reports have shown that mitochondria associated with virulence of pathogenic fungi. there few studies on mechanisms mitochondria-mediated azoles resistance. Here, we first performed mitochondrial proteomic analysis multiple Candida species ( albicans , Nakaseomyces glabrata Pichia kudriavzevii, and...
The objective of the study was to systematically evaluate and perform a meta-analysis on adherence high-flow nasal cannula (HFNC) humidified oxygen therapy its influencing factors in elderly patients with stable chronic obstructive pulmonary disease (COPD). Relevant literature HFNC COPD retrieved from PubMed, EMbase, Web Science, Cochrane Library databases. Cross-sectional studies, case-control cohort studies were included. Screening quality assessment conducted using Endnote X9 software....
Background: Allergen immunotherapy (AIT) is the most effective treatment for atopic allergic diseases, aiming to induce regulatory T cells (Treg) that modify immune response specific allergens, which leads long-term tolerance and reduced symptoms. Enhancing Treg activity crucial improving outcomes. In a previous murine model study, we examined effects of synthetic methylated DNA oligodeoxynucleotide (ODN) from Bl-T2 m5C motif Bifidobacterium longum subsp. infantis . The ODN contains BI-T2...