A5100348163- Liver Disease Diagnosis and Treatment
- Flavonoids in Medical Research
- Lipid metabolism and disorders
- Natural product bioactivities and synthesis
- Cholesterol and Lipid Metabolism
- CAR-T cell therapy research
- Chromatography in Natural Products
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrospun Nanofibers in Biomedical Applications
- Genomics, phytochemicals, and oxidative stress
- Congenital Diaphragmatic Hernia Studies
- Wound Healing and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Amyotrophic Lateral Sclerosis Research
- Sepsis Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Tuberous Sclerosis Complex Research
- Advanced Thermodynamic Systems and Engines
- Microfluidic and Capillary Electrophoresis Applications
- Risk and Safety Analysis
- Hydrogels: synthesis, properties, applications
- Biochemical and Structural Characterization
Xuzhou Medical College
2025
Xuzhou No.1 People's Hospital
2025
Zhejiang University of Technology
2019-2023
Duke University Hospital
2020-2023
Duke Medical Center
2020-2023
Tianjin Medical University Cancer Institute and Hospital
2023
Harbin Medical University
2019-2023
Second Affiliated Hospital of Harbin Medical University
2023
Jiangsu Province Hospital
2021
Hangzhou Academy of Agricultural Sciences
2019-2021
Hesperetin as a major bioflavonoid in citrus fruits improves NAFLD by suppressing hepatic oxidative stress and inflammation.
The relationship between poor in vivo bioavailability and effective pharmacological activity are not yet fully clarified for many flavonoids. analysis of flavonoids-induced alterations the gut microbiota represents a promising approach to provide useful clues elucidate mechanism action. Here, we investigate effect myricetin supplementation on high-fat-diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) rats explore associations with through high-throughput analyses. 12-week fecal...
Nonalcoholic fatty liver disease (NAFLD) has become the most common worldwide; thus, a dietary supplement that can restrict hepatic fat accumulation is needed.
The linear relationship of Nov GII VP1 protein in the range 2.5–320 ng mL −1 was Y = 0.6784 X − 1.1443, R 2 0.9935 and lowest limit detection 0.61 .
Background.Sepsis is a life-threatening condition characterized by dysregulated host immune response to infection.Currently, stress hyperglycemia frequently associated with an unfavorable prognosis in cardiovascular and cerebrovascular disease.During sepsis, the progression of inflammation often leads aberrant metabolic indicators.However, association between stress-induced ratio (SHR) sepsis patients admitted intensive care unit (ICU) remains uncertain.Objectives.This study aimed explore...
Diffuse large B-cell lymphoma (DLBCL) is the major type of aggressive lymphoma. High-grade (HGBCL) with MYC/BCL2 double-hit (DH) represents a distinct entity dismal prognosis after standard immunochemotherapy in current WHO classification. However, whether TP53 mutation synergizes MYC abnormalities (MYC rearrangement and/or Myc protein overexpression) contributing to HGBCL-like biology and not well investigated. In this study, patients DLBCL MYC/TP53 demonstrated poor clinical outcome,...
Desilked silkworm ( Bombyx mori L .) pupae oil has been identified as a valuable source of unsaturated fatty acids (UFAs). However, direct consumption is food safety issue due to the presence sn ‐1,3 triacylglycerols (TAGs), including palmitic acid (PA). A simple, selective and safe conversion structured (STAGs) with high UFA content highly desirable. Novel STAGs low PA α ‐linolenic (ALA), oleic (OA) linoleic (LA) were synthesized from using solvent‐free system catalyzed by Lipozyme RM IM....
Rationale: Although surgery, radioiodine therapy, and thyroid hormone therapy are the primary clinical treatments for differentiated carcinoma (DTC), effective locally advanced or progressive DTC remains challenging.BRAF V600E, most common BRAF mutation subtype, is highly related to DTC.Previous studies prove that combination of kinase inhibitors chemotherapeutic drugs may be a potential approach treatment.In this study, supramolecular peptide nanofiber (SPNs) co-loaded with dabrafenib (Da)...
Due to the complexity of bioactive ingredients in biological samples, screening target proteins is a complex process. Herein, feasible strategy for directing protein immobilization on silica magnetic beads ligand fishing based SpyTag/SpyCatcher (ST/SC)-mediated anchoring presented. Carboxyl functional groups surface silica-coated (SMBs) were coupled with SC using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride/N-hydroxysulfosuccinimide method, named SC-SMBs. The green...
To determine the influence of ultrasound/microbubble-mediated miR-424-5p delivery on trophoblast cells and underlying mechanism.Blood pressure 24-h proteinuria patients with preeclampsia (PE) were measured as well levels amine oxidase copper containing 1 (AOC1) in placental tissues. HTR-8/Svneo TEV-1 subjected to cell transfection or ultrasonic microbubble for determination expression miR-424-5p, AOC1, β-catenin c-Myc proliferation, apoptosis, migration invasiveness. The concentrations...
In cultured astroglia, cysteamine induces the accumulation of peroxidase-positive cytoplasmic inclusions in context a generalized cellular stress response. present study, systemic administration over 3 week period induced HSP27, 72, 90, and GRP94 (stress proteins) astrocytes significantly increased numbers astrocytic various brain regions relative to controls. Similar patterns HSP expression were also observed at 24 hours following treatment indicating that may be very proximal event...
Chitosan and its derivatives show potent biocompatibility, biodegradability, antimicrobial activity, hemostatic effects, wound healing properties. Their application in dressings has garnered substantial research interest. In this work, we prepared a drug-loaded hydrogel by mixing N-glycosylated chitosan with polyvinyl alcohol (PVA), followed loading of ofloxacin. A 2:1 volume ratio to PVA was found be optimal based on swelling water evaporation rates. The slow-drug-release performance the...
Oxidized low-density lipoprotein (oxLDL)-induced macrophage foam cell formation plays an important role in atherosclerosis progression. Baicalein is a constituent of Scutellaria baicalensis. Herein, we investigated the effect baicalein on and underlying mechanism. The THP-1 was established by oxLDL stimulation effects cholesterol uptake efflux were analysed molecular docking, ELISA, immunofluorescence, western blot, inhibitor siRNA experiment. results showed that suppressed oxLDL-induced...
C 10 H 7 FO 3 ,monoclinic, P12 1 /c1(no.14), a =7.584 Source of materialAs olution 2-ethoxy-2-oxoethyl 2-(4-fluorophenyl)-acetate (0.96 g, 4mmol) in dry THF was added dropwise to asuspension NaH an ice cold bath.The stirring maintained at room temperature for 5h.Water and the solution extracted twice with ethyl ether.The aqueous phase cooled 0 °Cand then acidified concentrated hydrochloric acid give asolid precipitate.The title compound crystallized from ethanol-water (2:1, v/v)t og ive...
Ebola hemorrhagic fever is a disease caused by one of five different viruses.Four the strains can cause severe illness in humans and animals.Humans be infected other if they come contact with body fluids from an person or contaminated objects persons.Humans also exposed to virus, for example, butchering animals.Deadly human outbreaks have been confirmed following countries: Democratic Republic Congo (DRC), Gabon, South Sudan, Ivory Coast, Uganda, (ROC), Guinea Liberia.In this sense, it vital...
In order to reduce the Operation and Maintenance (O&M) costs existing in wind farms, optimization for spare parts inventories becomes necessary. this paper, inventory management model of Wind Turbine (WT) component's is established with non-stationary stochastic demands under continuous review (r, Q) polices. Herewith, expert knowledge involved build a Fault Tree (FT) that presents complicated dependence information among WT components. Moreover, Binary Decision Diagram (BDD) Barlow-Proschan...
Abstract Background In recent years, births to older mothers and multiparous have increased rapidly with the change of birth policy in China. And advanced age are more likely maternal complications poor outcomes. We aimed estimate trends underlying risk factors mortality. Methods this systematic assessment, we used data from National Maternal Child Health Routine Reporting System (2013–2018), Jiangsu Provincial Mortality Surveillance (2017–2018), Integrated (2018), City Statistical Yearbooks...