A5058982057- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- CAR-T cell therapy research
- Immune cells in cancer
- Chronic Lymphocytic Leukemia Research
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Nerve injury and regeneration
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Spine and Intervertebral Disc Pathology
- Effects of Radiation Exposure
- Mesenchymal stem cell research
- Ubiquitin and proteasome pathways
The University of Sydney
2025
Children's Hospital of Chongqing Medical University
2022-2024
Chongqing Medical University
2022-2024
Wuxi Ninth People's Hospital
2024
Soochow University
2024
China International Science and Technology Cooperation
2023-2024
Guangzhou Medical University
2018-2023
Nanjing Medical University
2023
Duke Medical Center
2021
Nantong University
2020
Abstract The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally vulnerable to infections, systematic analysis diverse cohorts by is needed. We performed a multicenter study including 105 536 age-matched noncancer confirmed COVID-19. Our results showed had higher risks in all severe outcomes. Patients hematologic cancer, lung or metastatic (stage IV) the highest frequency events. nonmetastatic...
PD-1/L1 and CTLA-4 blockade immunotherapies have been approved for 13 types of cancers are being studied in diffuse large B-cell lymphoma (DLBCL), the most common aggressive lymphoma. However, whether both PD-1 checkpoints active clinically significant DLBCL is unknown. Whether ligands expressed by tumor cells or microenvironment critical immune checkpoint unclear. We performed immunophenotypic profiling 405 patients with de novo using a MultiOmyx immunofluorescence platform simultaneously...
Phosphoglycerate kinase 1 (PGK1), a critical component of the glycolytic pathway, relates to development various cancers. However, mechanisms PGK1 inhibition and physiological significance inhibitors in cancer cells are unclear. Long non-coding RNAs (lncRNAs) play vital role tumor growth progression. Here, we identify lncRNA LINC00926 that negatively regulates expression predicts good clinical outcome breast cancer. downregulates through enhancement ubiquitination mediated by E3 ligase...
Oxaliplatin (OXA) is one of the most common chemotherapeutics in advanced hepatocellular carcinoma (HCC), resistance which poses a big challenge. Long noncoding RNAs (lncRNAs) play vital roles chemoresistance. Therefore, elucidating underlying mechanisms and identifying predictive lncRNAs for OXA needed urgently.RNA sequencing (RNA-seq) fluorescence situ hybridization (FISH) were used to investigate OXA-resistant (OXA-R) lncRNAs. Survival analysis was performed determine clinical...
The combination of immune checkpoint blockade (ICB) with chemotherapy significantly improves clinical benefit cancer treatment. Since is often associated adverse events, concomitant treatment drugs managing side effects frequently used in the therapy. However, whether these ancillary could impede immunotherapy remains unknown. Here, we showed that ∆9-tetrahydrocannabinol (THC), key ingredient approved for chemotherapy-caused nausea, reduced therapeutic effect PD-1 blockade. endogenous...
The present study evaluated the effect of epigallocatechin-3-gallate (EGCG), most abundant catechin in green tea, on irradiation-induced pulmonary fibrosis and elucidated its mechanism action. A rat model was generated using a 60Co irradiator dose 22 Gy. Rats were intraperitoneally injected with EGCG (25 mg/kg) or dexamethasone (DEX; 5 daily for 30 days. Mortality rates lung index values calculated. severity by assaying hydroxyproline (Hyp) contents tissue sections post-irradiation....
Runt-Related Transcription Factor 1 (RUNX1) is highly expressed in the Mesenchymal (Mes) subtype of glioblastoma (GBM). However, specific molecular mechanism RUNX1 Mes GBM remains largely elusive. In this study, cell and tumor tissue typing were performed by RNA-sequencing. Co-immunoprecipitation (co-IP) immunofluorescence (IF) employed to identify members transcriptional protein complex. Bioinformatics analysis, chromatin immunoprecipitation (ChIP), luciferase reporter experiments utilized...
Abstract Purpose: Diffuse large B-cell lymphoma (DLBCL) is molecularly and clinically heterogeneous, can be subtyped according to genetic alterations, cell-of-origin, or microenvironmental signatures using high-throughput genomic data at the DNA RNA level. Although proteomic profiling has not been available for DLBCL subtyping, MYC/BCL2 protein double expression (DE) an established prognostic biomarker in DLBCL. The purpose of this study reveal relative roles genetic, phenotypic, biomarkers....
Breast cancer is the most commonly diagnosed and leading cause of death among women in worldwide.Triple-negative breast (TNBC) has a poor clinical outcome.The antitumor efficacy Ilamycins, natural products with anti-tuberculosis activity isolated from deep sea-derived Streptomyces atratus, TNBC not been investigated, mechanisms remain elusive.Here, we demonstrated that Ilamycin-E, but -F, decreases cell viability, inhibits G1/S cycle progression, promotes apoptosis lines HCC1937...
The exploration of cellular heterogeneity within the tumor microenvironment (TME) via single-cell RNA sequencing (scRNA-seq) is essential for understanding cancer progression and response to therapy. Current scRNA-seq approaches, however, lack spatial context rely on incomplete datasets ligand-receptor interactions (LRIs), limiting accurate cell type annotation cell-cell communication (CCC) inference. This study addresses these challenges using a novel graph neural network (GNN) model that...
Introduction: Epilepsy, a complex neurological disorder characterised by recurrent seizures and significant genetic heterogeneity, presents considerable challenges form accurate diagnosis drug target identification. While traditional genomewide association studies (GWAS) sequencing technologies have advanced our understanding of epilepsy-related gene targets, they often struggle to identify novel rare variants crucial for precise targeted development. The increasing availability large-scale...
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity of lymphoma. Cell-of-origin (COO) classification DLBCL required in routine practice by the World Health Organization for biological and therapeutic insights. Genetic subtypes uncovered recently are based on distinct genetic alterations DLBCL, which different from COO defined gene expression signatures normal B cells retained DLBCL. We hypothesize that classifiers incorporating both genome-wide gene-expression pathogenetic...
Background Primary central nervous system lymphoma (PCNSL) is a highly aggressive and rare extranodal non-Hodgkin (NHL). The MSKCC the IELSG scores represent most widely used prognostic models, but many changes have occurred in therapeutic protocols since their development. Moreover, PCNSL patients cannot be classified using score. We thus aimed to create novel, effective feasible model for PCNSL. Methods included 248 diagnosed with Our primary endpoint was overall survival (OS) we receiver...
Abstract Metastasis is the leading cause of cancer-related death. The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs a key step during extravasation hematogenous metastasis. Surgery common intervention for most primary solid tumors. However, surgical trauma-related systemic inflammation facilitates metastasis by increasing spread to vascular (ECs). Currently, there are no effective interventions prevent Here, we show that HECTD3 deficiency...