A5077005650- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Ubiquitin and proteasome pathways
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Neutropenia and Cancer Infections
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mesenchymal stem cell research
- Chronic Myeloid Leukemia Treatments
- Inflammatory Biomarkers in Disease Prognosis
- CNS Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Epigenetics and DNA Methylation
- Inflammasome and immune disorders
- PARP inhibition in cancer therapy
Sun Yat-sen University
2025
Fifth Affiliated Hospital of Sun Yat-sen University
2025
Shandong Provincial Hospital
2015-2024
Shandong University
2015-2024
Henry Ford Hospital
2024
Shandong First Medical University
2020-2024
National Clinical Research Center for Digestive Diseases
2021-2024
Soochow University
2021-2024
First Affiliated Hospital of Soochow University
2021-2024
Duke Medical Center
2020-2023
The incidence of non-Hodgkin's lymphoma (NHL) has increased steadily over the past few decades. Elucidating its global burden will facilitate more effective disease management and improve patient outcomes. We explored burden, risk factors, trends in mortality NHL globally.The up-to-date data on age-standardized rates were retrieved from GLOBOCAN 2020, CI5 volumes I-XI, WHO database, Global Burden Disease (GBD) 2019, focusing geographic disparities worldwide. reported by sex age, along with...
Abstract Background Hippo-Yes-associated protein (YAP) signaling is a key regulator of organ size and tumorigenesis, yet the underlying molecular mechanism still poorly understood. At present, significance Hippo-YAP pathway in diffuse large B-cell lymphoma (DLBCL) ill-defined. Methods The expression YAP DLBCL was determined public database clinical specimens. effects knockdown, CRISPR/Cas9-mediated deletion, inhibitor treatment on cell proliferation cycle were evaluated both vitro vivo. RNA...
Abstract Background Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involved in broad cellular processes. This molecule possesses contradictory roles carcinogenesis, as it has been documented to both suppressing augmenting tumor growth. project aimed explore the expression functions of Sirt6 diffuse large B-cell lymphoma (DLBCL), especially with regards regulatory role OSS_128167, novel small molecular inhibitor targeting Sirt6. Methods...
Abstract Purpose: Diffuse large B-cell lymphoma (DLBCL) is molecularly and clinically heterogeneous, can be subtyped according to genetic alterations, cell-of-origin, or microenvironmental signatures using high-throughput genomic data at the DNA RNA level. Although proteomic profiling has not been available for DLBCL subtyping, MYC/BCL2 protein double expression (DE) an established prognostic biomarker in DLBCL. The purpose of this study reveal relative roles genetic, phenotypic, biomarkers....
Klotho, is a transmembrane protein, performs as circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast factor (FGF), Wnt signaling pathways. These pathways are involved in development progression B cell lymphoma. We aimed to explore expression pattern functional mechanism Klotho diffuse large lymphoma (DLBCL). Immunohistochemistry (IHC) western blotting were performed detect level DLBCL patients lines. Tumor suppressive effect was...
Lymphoid neoplasms, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and NK/T cell are a major cause of blood cancer morbidity mortality. CD38 (cyclic ADP ribose hydrolase) is transmembrane glycoprotein expressed on the surface plasma cells MM cells. The high expression across other lymphoid malignancies its restricted in normal tissues make an attractive target for immunotherapy. CD38-targeting antibodies, like daratumumab, have been approved treatment tested against leukemia...
To the Editor: Cervical cancer (CC) is second leading cause of death in women, representing a major global health challenge.[1] squamous cell carcinoma (CSCC) accounts for 70% CC cases, and pelvic lymph node metastasis critical CC-related death.[2] Thus, understanding underlying mechanisms tumor spread through lymphatic vessels becomes imperative.[3] RNA helicases are involved almost all aspects metabolism.[4] DEAD-box helicase 24 (DDX24), one least explored helicases, was upregulated...
Diffuse large B-cell lymphoma (DLBCL) is the major type of aggressive lymphoma. High-grade (HGBCL) with MYC/BCL2 double-hit (DH) represents a distinct entity dismal prognosis after standard immunochemotherapy in current WHO classification. However, whether TP53 mutation synergizes MYC abnormalities (MYC rearrangement and/or Myc protein overexpression) contributing to HGBCL-like biology and not well investigated. In this study, patients DLBCL MYC/TP53 demonstrated poor clinical outcome,...
Waldenström macroglobulinemia (WM) is a distinct type of indolent lymphoplasmacytic lymphoma (LPL) with high frequency MYD88L265P mutation. Treatment for WM/LPL highly variable in clinic and ibrutinib (a Bruton tyrosine kinase inhibitor, BTKi) has become new treatment option WM. To investigate the clinical impact genetic alterations WM, we assembled large cohort 219 WMs 12 LPLs dividing into two subcohorts: training cohort, patients sequenced by same targeted 29-gene next-generation...
Abstract Multiple studies have demonstrated that diffuse large B-cell lymphoma (DLBCL) can be divided into subgroups based on their biology; however, these biological overlap clinically. Using machine learning, we developed an approach to stratify patients with DLBCL four survival characteristics. This uses data from the targeted transcriptome predict subgroups. expression levels of 180 genes, our model reliably predicted and was validated using independent groups patients. Multivariate...
Genomic instability is a significant driver of cancer.As the sensor cytosolic DNA, cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway plays critical role in regulating anti-tumor immunity and cell death.However, regulatory mechanisms STING diffuse large B-cell lymphoma (DLBCL) are still undefined.In this study, we reported that sterile alpha motif HD domain-containing protein 1 (SAMHD1) deficiency induced expression inhibited tumor growth DLBCL.High level SAMHD1 was...
Condensin, a family of structural maintenance chromosome complexes, has been shown to regulate compaction and segregation during mitosis. NCAPD3, HEAT-repeat subunit condensin II, plays dominant role in condensin-mediated dynamics but remains unexplored lymphoma. The study aims unravel the molecular function mechanism NCAPD3 diffuse large B-cell lymphoma (DLBCL). expression clinical significance were assessed public database specimens. Chromosome spreads, co-immunoprecipitation (co-IP), mass...
Nucleostemin (NS), a p53-binding protein, has been shown essential for stem and cancer cell proliferation implicated in oncogenesis. To explore potential contributions of NS to the development clear renal carcinomas (ccRCCs), we determined expression ccRCC lines, paired normal malignant tissues from 31 patients with ccRCC. mRNA and/or protein was observed all four lines 27 (87%) tumour specimens. Surprisingly, 16 (52%) adjacent samples also expressed its levels them were comparable those...
The biological and clinical features of chronic lymphocytic leukemia (CLL) exhibited profound heterogeneity across Chinese patients predominately European descent. However, the age-related peculiarities risk assessment CLL remained ill-defined. present study demonstrated that were characterized by earlier age at onset in China (median diagnosis: 63 years old) than United States 69 old). Young from Shandong Provincial Hospital database displayed prolonged overall survival Surveillance,...
Up-regulation of heat shock protein 70 (HSP70) could be elicited primarily by in former studies, and this was proved to associated with cancer progression. Burkitt's lymphoma is one highly aggressive B-cell non-Hodgkin's the fastest growing human tumors. To investigate effect HSP70 expression on sensitivity Burkitt cells (Raji cells) chemotherapy its role involvement PI3K/AKT pathway, we evaluated effects LY294002, a PI3K inhibitor, cell adriamycin (ADM) or cisplatin (DDP). In present study,...
Background: Accumulating evidence suggested that tumor microenvironment and host immune system played important roles in determining the clinical course outcome of human malignancies. The derived neutrophil to lymphocyte ratio (dNLR) absolute count (ALC) were demonstrated act as a prognostic factor several Nevertheless, significance them extranodal natural killer/T-cell lymphoma (ENKTL) patients has never been explored. Patients methods: A total 33 newly diagnosed with ENKTL included this...
Abstract Background Patients diagnosed as diffuse large B cell lymphoma (DLBCL) with CD5 positive normally have a worse outcome and poorly respond to the regulatory treatment strategy. Results We recently reported differently expressed tRFs their potential target-genes of in patients CD5+ R/R DLBCL. Differently were detected by Illumina NextSeq instrument results verified quantitative real-time reverse transcription-PCR. tRF2Cancer database was searched compared results. Further research...
The antitumor mechanisms of adriamycin (ADR) have been thought to contribute induction apoptosis and inefficiency DNA repair, processes that are a large extent mediated by mitochondria. This study aimed investigate characteristics ADR, including its antineoplastic activity, drug resistance, unexpected toxicity in non-Hodgkin lymphoma (NHL) Raji cells at the mitochondrial proteomic level. alterations proteome treated with ADR were analyzed two-dimensional differential in-gel electrophoresis...