A5023985119- Pancreatic and Hepatic Oncology Research
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Phytochemistry and Biological Activities
- Pharmacogenetics and Drug Metabolism
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Educational Reforms and Innovations
- PI3K/AKT/mTOR signaling in cancer
- Drug Solubulity and Delivery Systems
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant-based Medicinal Research
- Computational Drug Discovery Methods
- Traditional Chinese Medicine Analysis
- Lung Cancer Treatments and Mutations
- Ginger and Zingiberaceae research
- Colorectal Cancer Treatments and Studies
- Advanced Drug Delivery Systems
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
- Gallbladder and Bile Duct Disorders
- Natural product bioactivities and synthesis
- Phytochemistry and biological activity of medicinal plants
Hebei General Hospital
2021-2025
Zhujiang Hospital
2024-2025
Southern Medical University
2024-2025
Xuzhou Medical College
2019-2024
Yangzhou University
2021-2024
First People's Hospital of Chongqing
2022-2024
Xiangya Hospital Central South University
2024
Central South University
2015-2024
Foshan University
2024
Hebei Medical University
2023-2024
The incidence of non-Hodgkin's lymphoma (NHL) has increased steadily over the past few decades. Elucidating its global burden will facilitate more effective disease management and improve patient outcomes. We explored burden, risk factors, trends in mortality NHL globally.The up-to-date data on age-standardized rates were retrieved from GLOBOCAN 2020, CI5 volumes I-XI, WHO database, Global Burden Disease (GBD) 2019, focusing geographic disparities worldwide. reported by sex age, along with...
Background: The objective of this study was to investigate antioxidant and anti-inflammatory activity cabbage phytochemicals. Materials Methods: Color coordinates were evaluated by colorimetry, the activities analyzed spectrophotometer for some common varieties. Results: Red heads had highest total contents followed Savoy, Chinese green heads. variety ABTS (2,2-azino-di-(3-ethylbenzthiazoline-sulfonic acid) activity, 5.72 <TEX>${\mu}mol$</TEX> TE/g fw (Trolox equivalent). DPPH (free radical...
The key to successful coupling in the synthesis of (±)-quadrangularin A (1) was introduction tert-butyl groups precursor block two reactive positions. Thus, oxidative 3,5-di-(tert-butyl)resveratrol carried out regioselectively an efficient total natural product. Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z603097_s.pdf or from author. Please note: publisher not responsible content functionality any supporting supplied by...
Organophosphorus pesticides (OPs) are an important class of common pesticides. However, due to the abuse organophosphorus pesticides, pesticide residue problems have been highlighted. In this study, colorimetric detection method for OPs residues was established based on broadspectrum aptamer. Through optimization, isocarbophos and omethoate were analyzed verify performance assay. Under optimal conditions, proved effective detecting range 50-1000 ng/mL 100-500 ng/mL. The protective effects...
Schisandra chinensis (S. chinensis) is a traditional Chinese herbal medicine widely used for the treatment of liver disease, whose main active components are lignans. However, action mechanisms lignans in S. remain unclear. This study aimed to investigate protective effect and related molecular mechanism lignan extract (SLE) against carbon tetrachloride- (CCl4-) induced acute injury mice. Different doses SLE at 50, 100, 200 mg/kg were administered daily by gavage 5 days before CCl4...
Background Apixaban (API) and rivaroxaban (RIVA) are orally available inhibitors of coagulation factor Xa commonly used to treat cancer-related venous thrombosis. Ribociclib (RIBO), a first-line treatment for hormone receptor-positive/human epidermal growth receptor 2 negative (HR + /HER2 − ) advanced breast cancer, is an inhibitor CYP3A4, P-gp, BCRP. Given the potential these drugs be co-administered in clinical settings, there limited information regarding pharmacokinetic drug-drug...
AIM:To investigate the hepatoprotective activity of tea polyphenols (TP) and its relation with cytochrome P450 (CYP450) expression in mice. METHODS:Hepatic CYP450 CYPb5 levels were measured by UV-spectrophotometry mice 2 d after intraperitoneal TP (25, 50 100 mg/kg per day).Then intragastricly pre-treated (100, 200 400 day) for six days before paracetamol (1000 mg/kg) was given.Their acute mortality compared that control mice.The 200, five (500 given.Hepatic CYP2E1 CYP1A2 protein mRNA...
To explore the potential of non-ionic surfactants as novel intranasal absorption enhancers.Taking sumatriptan succinate (SMS) a model drug, influence different surfactants, including laurate sucrose ester (SE), cremophor EL and poloxamer 188, on SMS was investigated using an in situ nasal perfusion technique rats. Ciliotoxicity evaluated toad palate model. In vivo behavior selected formulations studied rats.All increased remarkably but with varied extent trend. Moreover, it revealed that at...
Background: To establish the combination of doxorubicin (DOX) and silybin (SLB) in oral hepatic-targeting liposomes with goal reducing cardiotoxic side effects improve hepatoma treatment. Methods: Distearoylphosphatidylethanolamine–polyethylene glycol–cholic acid-modified (CA-LP) were used to encapsulate DOX SLB (CA-LP–DOX/SLB), hepatic targeting, efficacy against cardioprotective evaluated by cell toxicity, scratch apoptosis vitro studies, pharmacokinetics pharmacodynamics vivo studies....
Abstract While pachymic acid (PA), a key component of Poria cocos (Schw.) , has demonstrated anti‐tumor effects in lung, breast, and pancreatic cancers, its impact on renal cell carcinoma (RCC) is unclear. This study evaluated the effect PA proliferation, migration, apoptosis human cancer A498 ACHN cells as well xenograft mice using wound scratch test, Western blotting, co‐immunoprecipitation assays. In dose‐ time‐dependent manner, exhibited significant inhibition RCC invasion, accompanied...
Pancreatic ductal adenocarcinoma (PDAC) is challenging to treat due its immunosuppressive tumor microenvironment (TME) and resistance immune checkpoint inhibitors. This study aims discover new therapeutic targets predictive biomarkers for PDAC. Using Mendelian randomization, we studied causal relationships between PDAC an array of cell traits, bacterial inflammatory factors, blood metabolites. We employed large genome-wide association datasets the two-sample MR approach investigation. Our...
ABSTRACT Almonertinib has been approved for the first‐line therapy of advanced epidermal growth factor receptor (EGFR) mutation‐positive non‐small cell lung cancer (NSCLC). As a hepatoprotective agent, magnesium isoglycyrrhizinate (MgIG) was widely used in treatment drug‐induced liver injury. Although is commonly prescribed combination with MgIG clinical application, interaction research between them not reported. This conducted to explore influences on pharmacokinetics rats and investigate...
The third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), osimertinib, aumolertinib, and furmonertinib represent a new treatment option for patients with EGFR p.Thr790 Met (T790 M)-mutated non-small cell lung cancer (NSCLC). Currently, there are no studies reporting the simultaneous quantification of these three drugs. A simple ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed validated quantitative...