A5046663887- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Biomedical Text Mining and Ontologies
- Cell Image Analysis Techniques
- Semantic Web and Ontologies
- Ferroptosis and cancer prognosis
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Pancreatic and Hepatic Oncology Research
- Heart Failure Treatment and Management
- AI in cancer detection
- Machine Learning in Healthcare
- Pain Management and Treatment
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Artificial Intelligence in Healthcare
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- Biofuel production and bioconversion
- Spine and Intervertebral Disc Pathology
- Scientific Computing and Data Management
- Spinal Fractures and Fixation Techniques
- RNA modifications and cancer
- Image Processing Techniques and Applications
University of Pecs
2015-2025
SignPath Pharma (United States)
2024
Menlo School
2024
NeoGenomics (United States)
2018-2023
Semilab (Hungary)
2023
University of New Haven
2021
Neogen (United States)
2019-2020
Yale University
2013-2019
Heart failure (HF) is one of the leading causes hospital admissions in US. Readmission within 30 days after a HF hospitalization both recognized indicator for disease progression and source considerable financial burden to healthcare system. Consequently, identification patients at risk readmission key step improving management patient outcome. In this work, we used large administrative claims dataset (1) explore systematic application neural network-based models versus logistic regression...
Abstract Purpose: Diffuse large B-cell lymphoma (DLBCL) is molecularly and clinically heterogeneous, can be subtyped according to genetic alterations, cell-of-origin, or microenvironmental signatures using high-throughput genomic data at the DNA RNA level. Although proteomic profiling has not been available for DLBCL subtyping, MYC/BCL2 protein double expression (DE) an established prognostic biomarker in DLBCL. The purpose of this study reveal relative roles genetic, phenotypic, biomarkers....
Pathology images contain rich information of cell appearance, microenvironment, and topology features for cancer analysis diagnosis. Among such features, becomes increasingly important in immunotherapy. By analyzing geometric hierarchically structured distribution topology, oncologists can identify densely-packed cancer-relevant communities (CCs) making decisions. Compared to commonly-used pixel-level Convolution Neural Network (CNN) cell-instance-level Graph (GNN) CC are at a higher level...
Anterior lumbar interbody fusion with dorsal percutaneous pedicle screw fixation (ALIF+D) is a well-described technique treating lumbosacral degenerative diseases. Mobilising the common iliac arteries and veins (CIA CIV) during ALIF+D approach may increase risk of bleeding when bifurcations are low. This study demonstrates that in such cases, right-sided oblique (OLIF+D) offers novel alternative to approach. Twenty-one patients were operated on approach, twenty using OLIF+D technique....
Many viruses target cytoplasmic polyA binding protein (PABPC) to effect widespread inhibition of host gene expression, a process termed viral host-shutoff (vhs). During lytic replication Epstein Barr Virus (EBV) we observed that PABPC was efficiently translocated from the cytoplasm nucleus. Translocated diffusely distributed but excluded compartments. Vhs during EBV infection is regulated by alkaline nuclease, BGLF5. Transfection BGLF5 alone into BGLF5-KO cells or uninfected 293 promoted...
Diffuse large B-cell lymphoma (DLBCL) is the most common type of with high mutation burdens but a low response rate to immune checkpoint inhibitors. In this study, we performed targeted next-generation sequencing and fluorescent multiplex immunohistochemistry, investigated clinical significance immunological effect numbers in 424 DLBCL patients treated standard immunochemotherapy. We found that KMT2D TP53 nonsynonymous mutations (MUT) were significantly associated increased numbers,...
Authors of biomedical publications use gel images to report experimental results such as protein-protein interactions or protein expressions under different conditions. Gel offer a concise way communicate findings, not all which need be explicitly discussed in the article text. This fact together with abundance and their shared common patterns makes them prime candidates for automated image mining parsing. We introduce an approach detection images, present workflow analyze them. are able...
SUMMARY: A new method is described for the efficient conversion of Schizosaccharomyces pombe cells into protoplasts. The following parameters guanine uptake determined in whole were unchanged protoplasts: K m value, requirement an energy source, sensitivity to competitive inhibitors, pH optimum, as well typical variation initial velocity observed during growth phase.
Existing analytical techniques are being improved or applied in new ways to profile the tissue microenvironment (TME) better understand role of cells disease research. Fully understanding complex interactions between many different types and functions is often slowed by intense data analysis required. Multiplexed Ion Beam Imaging (MIBI) has been developed simultaneously characterize 50+ cell their within TME with a subcellular spatial resolution, but this results sets that challenging...
The paper will present an approach to automate and accelerate detection of defective wafers in high-volume manufacturing by innovatively complementing fast, non-contact non-destructive photoluminescence wafer mapping with smart image classification using deep learning methods. Specific focus is on distinguishing regularly occurring defect patterns the measurement from those revealing atypical buried, electrically active defects, which are hard detect visual inspection map. latter should be...
A diminished level of pain following the operation and shortened hospitalization are distinct advantages minimally invasive spine surgery (MISS). However, manipulating with additional MISS tools (e.g., distraction compression devices) is often cumbersome. Our paper draws attention to a cost-free, fast, indirect decompression method that can be used in acute treatment thoracolumbar fractures. The presented involves ligamentotaxis by whole-body traction operating room combined percutaneous...
e20702 Background: Non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases, and is characterized by a poor response to chemotherapy low survival rate. While immunotherapy has recently emerged as successful approach in the treatment NSCLC patients only 20-25% show positive anti-PD/PDL1 therapy, stressing urgent need additional options. very heterogeneous disease with two most common types being adenocarcinoma (ADCA) squamous carcinoma (SCC). study using flow...
e14619 Background: Spatial locations of immune cells in the tumor microenvironment (TME) correlate with clinical outcome cancers. A worse patient has been reported oral squamous cancer for individuals an increased number regulatory T within 30µm CD8+ [1]. The spatial relationship between and PD-L1+ become area interest understanding PD-L1 inhibition. combined assessment CD8 NSCLC tumors was shown to outperform or alone as prognostic markers predicting treatment checkpoint inhibitors [2]....
Abstract Background: Granulosa cell tumors (GCTs) are rare tumor in ovaries accounting for 2-5% of all ovarian cancers. The main current treatment GCT is surgery, however a subset require chemotherapy residual and recurrent disease. malignancies often low-grade with five-year survival rate up to 90%, clinical characteristic these tendency late recurrence high the most critical factor death. As onset unpredictable, future research should focus on identifying both biomarkers prognosis...
Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is a cancer with the ability to modulate immune system evade detection. It sixth most frequently diagnosed 550,000 new cases 300,000 lives lost worldwide per year. New treatments for HNSCC are urgently needed as patients continue experience high mortality rate low response surgery chemotherapeutic treatments. Part of reason why difficult treat it upregulates expression immune-checkpoint signaling molecule TIGIT (T...