A5035124843- MicroRNA in disease regulation
- Toxic Organic Pollutants Impact
- Advanced Antenna and Metasurface Technologies
- Viral-associated cancers and disorders
- Atmospheric and Environmental Gas Dynamics
- Advanced Battery Materials and Technologies
- Precipitation Measurement and Analysis
- Herpesvirus Infections and Treatments
- Advancements in Battery Materials
- Emergency and Acute Care Studies
- Nuclear Structure and Function
- Antenna Design and Analysis
- Air Quality and Health Impacts
- Circular RNAs in diseases
- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Petroleum Processing and Analysis
- Soil Moisture and Remote Sensing
- Eosinophilic Disorders and Syndromes
- Atmospheric chemistry and aerosols
- IPv6, Mobility, Handover, Networks, Security
- Semiconductor materials and interfaces
- Plant Pathogenic Bacteria Studies
- Cytomegalovirus and herpesvirus research
- Marine and fisheries research
University of Arizona
2022-2024
University of California Division of Agriculture and Natural Resources
2024
Texas A&M University
2023-2024
Environment and Climate Change Canada
2001-2022
Massachusetts Institute of Technology
1998-2022
University Hospitals of Cleveland
2022
University of Guelph
2020
Yale University
2008-2018
Northrop Grumman (United States)
2011-2016
Beth Israel Deaconess Medical Center
2014
A large collection of new modENCODE and ENCODE genome-wide chromatin data sets from cell lines developmental stages in worm, fly human are analysed; this reveals many conserved features organization among the three organisms, as well notable differences composition locations repressive chromatin. This study describes numerous Homo sapiens, Drosophila melanogaster Caenorhabditis elegans generated by consortia. The results point to while identifying Genome function is dynamically regulated...
Solid electrolytes potentially enable rechargeable batteries with lithium metal anodes possessing higher energy densities than today's ion batteries. To do so the solid electrolyte must suppress instabilities that lead to poor coulombic efficiency and short circuits. In this work, electrodeposition was performed on single-crystal Li6La3ZrTaO12 garnets investigate factors governing penetration through brittle electrolytes. single crystals, grain boundaries are excluded as paths for...
mRNA expression profiling has suggested the existence of multiple glioblastoma subclasses, but their number and characteristics vary among studies etiology underlying development is unclear. In this study, we analyzed 261 microRNA profiles from The Cancer Genome Atlas (TCGA), identifying five clinically genetically distinct subclasses that each related to a different neural precursor cell type. These microRNA-based displayed signatures resembling those radial glia, oligoneuronal precursors,...
We report that herpes simplex virus type 1 (HSV-1) infection leads to the recruitment of protein kinase C (PKC) nuclear rim. In HEp-2 cells, PKC rim was initiated between 8 h and 12 postinfection. PKCdelta, a proapoptotic kinase, completely recruited upon with HSV-1. PKCalpha less dramatically relocalized mostly at infection, although some remained in cytoplasm. PKCzeta-specific immunofluorescence not significantly relocated The UL34 UL31 proteins, as well their association, were each...
Naïve T cells proliferate independently of cognate antigen when introduced into lymphopenic hosts. Lymphopenia-induced proliferation depends on low-affinity MHC/self-peptide complexes and IL-7. To elucidate the intracellular signals mediating this proliferation, we analyzed changes in gene expression naïve CD8 + at different times after their transfer a environment. The genes induced response to lymphopenia were largely an attenuated subset those turned up by full antigenic stimulation,...
Constipation is one of the most common outpatient diagnoses in primary care and gastroenterology clinics; however, there limited data on inpatient burden constipation United States. The aim this study was to evaluate admission rates, length stay, associated costs related from 1997 2010.We analyzed National Inpatient Sample Database for all patients which (ICD-9 codes: 564.0-564.09) principal discharge diagnosis 2010. statistical significance difference number hospital discharges, over period...
22 alkylated polycyclic aromatic hydrocarbons (alk-PAHs) were characterized in ambient air individually for the first time urban and semi-urban locations Toronto, Canada. Five unsubstituted PAHs included comparison. Results from measurements used to estimate benzo[a]pyrene equivalent toxicity (BaPeq) of individual compounds order investigate significance a single compound contributing overall toxic equivalency (TEQ) mixtures. To determine which merit further investigation, BaPeq values...
Cells infected with wild-type herpes simplex virus type 1 (HSV-1) show disruption of the organization nuclear lamina that underlies envelope. This is reflected in changes localization and phosphorylation lamin proteins. Here, we HSV-1 infection causes relocalization LEM domain protein emerin. In cells virus, emerin becomes more mobile membrane, viruses fail to express UL34 (pUL34) US3 (pUS3), no longer colocalizes lamins, suggesting a loss connection between lamina. Infection...
<h3>Objective</h3> To evaluate the impact of primary reconstruction postablative defects following transoral robotic surgery on function and risk orocutaneous fistula. <h3>Design</h3> Prospective nonrandomized clinical trial. <h3>Setting</h3> Tertiary academic medical center. <h3>Patients</h3> Thirty-one patients treated with pharyngectomy for malignant disease. Each case was analyzed patient age, sex, site tumor, pathologic characteristics, stage disease, complications, fistula rate,...
ABSTRACT Previous results indicated that the U L 34 protein (pU 34) of herpes simplex virus 1 (HSV-1) is targeted to nuclear membrane and essential for egress nucleocapsids. The normal localization pU virions requires S 3-encoded kinase phosphorylates lamin A/C. Moreover, was shown interact with A in vitro. In present study, glutathione -transferase/pU specifically pull down B1 from cellular lysates. To determine role these interactions on viral infectivity targeting inner (INM), determined...
Polycyclic aromatic hydrocarbons (PAHs) are of high concern to public health due their carcinogenic and mutagenic properties. Here, we present the first comprehensive quantitative analysis sources, potential source regions according sectors source-related human risks multi-year atmospheric measurements PAHs in Canadian Great Lakes Basin (GLB). The highest PAH concentrations were observed at a rural residential site (Egbert), followed by two regionally representative remote sites [Point Petre...
Early functional and oncological outcome studies suggest that transoral robotic surgery (TORS) may have a role for early stage cancers of the oropharynx. Unlike with traditional mandibular swing or pharyngotomy approaches, access to oropharynx reconstruction in TORS cases is limited. Maintaining good result necessitates preserving physiological function where possible. The principles should guide reconstructive surgeons include maintaining velopharyngeal sphincter prevent insufficiency,...
Long-term air monitoring data for POPs are required to determine the effectiveness of source reduction measures and factors controlling concentrations. Air samples were collected between 1992 2012 at three sites with different geographical characteristics (Burnt Island, Egbert Point Petre) in Canadian Great Lakes Basin (GLB) using high-volume samplers analyzed organochlorine pesticides (OCPs) polychlorinated biphenyls (PCBs). Spatial temporal trends gas-phase concentrations OCPs, selected...
We had previously reported that tetramethyl-O-NGDA (M4N), a synthetic derivative of the naturally occurring nordihydroguaiaretic acid (NDGA), is able to inhibit HIV Tat transactivation by blocking host Sp1 protein at cognate binding site on LTR promoter. The present studies were undertaken examine whether M4N replication herpes simplex virus (HSV), another Sp1-regulated virus. results showed in Vero cells, inhibits micromolar levels (IC50 = 43.5 microM) expression immediate early gene...
Abstract Purpose: We have previously shown that the transcriptional inhibitor tetra-O-methyl nordihydroguaiaretic acid (M4N) induces growth arrest in tumor cells and exhibits tumoricidal activity when injected intratumorally into cell explants mice. The experiments reported here were designed to determine whether M4N can be given systemically inhibit of five different human xenograft tumors. Experimental Design: Nude (nu/nu) mice bearing xenografts each types (i.e., hepatocellular carcinoma,...
We present new radio observations of the supernova SN 1979C made with Very Large Array (VLA) at 20, 6, 3.6, and 2 cm from 1991 July to 1998 October, which extend our previously published (Weiler et al.), began 8 days after optical maximum in 1979 April continued through 1990 December. find that emission has stopped declining flux density manner described by Weiler al. apparently entered a stage evolution. The observed "flattening," or possible brightening, light curves for is interpreted as...
Mutations of the NF2 gene on chromosome 22q are thought to initiate tumorigenesis in nearly 50% meningiomas, and deletion is earliest most frequent large-scale chromosomal abnormality observed these tumors. In aggressive deletions generally accompanied by presence segmental abnormalities involving other chromosomes, but reasons for this association unknown. We find that alterations accumulate during meningioma progression primarily tumors harboring deletions, suggesting 22q-associated...
Temporal and spatial trends of total air concentrations (gas + particle) halogenated flame retardants at the Canadian Great Lakes Basin were assessed (2005–2014).