A5102715305- Microbial Natural Products and Biosynthesis
- DNA Repair Mechanisms
- Protein purification and stability
- Fungal Biology and Applications
- Nutrition and Health in Aging
- CAR-T cell therapy research
- NF-κB Signaling Pathways
- Monoclonal and Polyclonal Antibodies Research
- Cancer therapeutics and mechanisms
- Signaling Pathways in Disease
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related Molecular Pathways
- Mesenchymal stem cell research
- GDF15 and Related Biomarkers
- Algal biology and biofuel production
- Biosimilars and Bioanalytical Methods
- Tissue Engineering and Regenerative Medicine
- Drug Transport and Resistance Mechanisms
- Blood properties and coagulation
- Nuclear Receptors and Signaling
- Cell death mechanisms and regulation
- Receptor Mechanisms and Signaling
Johns Hopkins University
2004-2006
Chang Gung Memorial Hospital
2005
We previously reported that Sp1-dependent Cdc2 gene expression is inhibited by tetra- O -methyl nordihydroguaiaretic acid (M 4 N) and M N likely responsible for causing growth arrest in N-treated transformed C3 cells. Here, we show after treatment cell-cycle arrest, of the survivin gene, a member inhibitor apoptosis family, also suppressed, mitochondrial apoptotic pathway activated. To confirm inhibition necessary N-induced apoptosis, tested effect adding back to Cell division was...
Abstract Purpose: We have previously shown that the transcriptional inhibitor tetra-O-methyl nordihydroguaiaretic acid (M4N) induces growth arrest in tumor cells and exhibits tumoricidal activity when injected intratumorally into cell explants mice. The experiments reported here were designed to determine whether M4N can be given systemically inhibit of five different human xenograft tumors. Experimental Design: Nude (nu/nu) mice bearing xenografts each types (i.e., hepatocellular carcinoma,...
PEGylation modification has been used to improve the pharmacokinetic properties of protein-based drugs. For example, PEGylated human growth hormone (hGH) shown exhibit better profiles than unmodified hGH. Unlike chemical hGH that is difficult be controlled result in homogeneity, microbial transglutaminase (mTGase) only conjugates poly(ethelene glycol) (PEG) on glutamine-40 (Q40) and glutamine-141 (Q141) hGH, glutamine residues exposed. Yet, an mTGase can selectively conjugate PEG 1 residue...
Antrodia camphorata is a fungus native to Taiwan, and it considered precious medicinal agent. We analyzed triterpenoids, polysaccharides 1,3-β-D-glucan, three major effective components in A. extracts (ACE). ACE exhibited selective cytotoxic effect on BxPC-3 human pancreatic cancer cells. markedly inhibited the migration ability of Treatment cells with resulted increase sub-G1 phase G2/M arrest. Apoptosis was confirmed by validating phosphatidylserine externalization, observation...