A5101849857- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Erythrocyte Function and Pathophysiology
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Microfluidic and Capillary Electrophoresis Applications
- Protein purification and stability
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advancements in Transdermal Drug Delivery
- Blood properties and coagulation
- Microfluidic and Bio-sensing Technologies
- Retinoids in leukemia and cellular processes
- Lipid Membrane Structure and Behavior
- Graphene and Nanomaterials Applications
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Biosensors and Analytical Detection
- Photodynamic Therapy Research Studies
- Berberine and alkaloids research
- Gold and Silver Nanoparticles Synthesis and Applications
- Molecular Sensors and Ion Detection
- 3D Printing in Biomedical Research
Shanghai Jiao Tong University
2016-2025
Northeastern University
2024
Nanjing Tech University
2024
Shandong Jianzhu University
2023
Beijing University of Posts and Telecommunications
2022
Guangxi Medical University
2013-2022
EVRAZ (Canada)
2022
Tianjin University
2022
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2022
University of Electronic Science and Technology of China
2022
Gold nanoparticles are enclosed in cellular membranes derived from natural red blood cells (RBCs) by a top-down approach. The gold exhibit complete membrane surface layer and biological characteristics of the source cells. combination inorganic with is compelling way to develop biomimetic nanostructures for future applications, such as those requiring evasion immune system.
Although microfluidics has shown exciting potential, its broad applications are significantly limited by drawbacks of the materials used to make them. In this work, we present a convenient strategy for fabricating whole-Teflon microfluidic chips with integrated valves that show outstanding inertness various chemicals and extreme resistance against all solvents. Compared other [e.g., poly(dimethylsiloxane) (PDMS)] chip few more advantages, such as no absorption small molecules, little...
A new thiol-containing colorimetric probe has been developed by using a chromene derivative, 7-nitro-2,3-dihydro-1H-cyclopenta[b]chromen-1-one (1). The molecule exhibited high selectivity and sensitivity for detecting thiol species as cysteine, homocysteine, glutathione in aqueous solution through rapid visual color change from colorless to yellow.
Injectable polymer microsphere-based stem cell delivery systems have a severe problem that they do not offer desirable environment for adhesion, proliferation, and differentiation because it is difficult to entrap large number of hydrophilic functional protein molecules into the core hydrophobic microspheres. In this work, soybean lecithin (SL) applied bone morphogenic protein-2 (BMP-2) nanoporous poly(lactide-co-glycolide) (PLGA)-based microspheres by two-step method: SL/BMP-2 complexes...
It is critical to detect and analyze the heavy metal pollutions in environments foods. Chemosensors have been widely investigated for fast detection of analytes such as metals due their unique advantages. In order improve sensitivity chemosensors, recently electrospun nanofibrous membranes (ENMs) explored immobilization chemosensors or receptors high surface‐to‐volume ratio, porosity, easiness fabrication functionalization, controllability nanofiber properties, low cost, easy detection, no...
Multiple drug resistance (MDR) in bacterial infections is developed with the abuse of antibiotics, posing a severe threat to global health. Tedizolid phosphate (TR-701) an efficient prodrug tedizolid (TR-700) against gram-positive bacteria, including methicillin-sensitive staphylococcus aureus (MSSA) and methicillin-resistant (MRSA). Herein, novel delivery system: Red blood cell membrane (RBCM) coated TR-701-loaded polylactic acid-glycolic acid copolymer (PLGA) nanoparticles...
Breast cancer, a pervasive malignancy affecting women, demands diverse treatment approach including chemotherapy, radiotherapy, and surgical interventions.
In this paper we present a simple and rapid method of modifying poly(dimethylsiloxane) (PDMS) surfaces with paraffin wax. PDMS that contains layer wax at its surface resists the absorption hydrophobic molecules; used fluorescence microscopy to confirm paraffin-modified rhodamine B. Furthermore, demonstrated microfluidic devices made from prevent efficiently transport gas molecules through bulk into microchannels. We characterized using water contact angle, optical transmission, X-ray...
This report describes a convenient method for the fabrication of miniaturized, reliable Ag/AgCl reference electrode with nanofluidic channels acting as salt bridge that can be easily integrated into microfluidic chips. The shows high stability millivolt variations. We demonstrated application this in portable chip is connected to USB-port microelectrochemical station and computer data collection analysis. low cost potential mass production makes it disposable an excellent candidate...
The multidrug resistance in tumor (MDR) is a major barrier to efficient cancer therapy. Modern pharmacological studies have proven that tetrandrine (TET) has great potential reversing MDR. However, it series of medication problems clinic such as poor water solubility, low oral bioavailability and short half-life vivo. Aiming at the above problems, red blood cell membrane-camouflaged TET-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (RPTNs) had been developed. RPTNs spherical...
Arsenic trioxide (ATO) has a significant effect on the treatment of acute promyelocytic leukemia (APL) and advanced primary liver cancer, but it still faces severe side effects. Considering these problems, red blood cell membrane-camouflaged ATO-loaded sodium alginate nanoparticles (RBCM-SA-ATO-NPs, RSANs) were developed to relieve toxicity ATO while maintaining its efficacy. (SA-ATO-NPs, SANs) prepared by ion crosslinking method, then RBCM was extruded onto surface obtain RSANs. The average...
This work describes a convenient microfluidic strategy with simple and minimal-requirement design for the generation of uniformly-sized alginate gel fibers diameters one order magnitude smaller than those formed in conventional methods. Different from common methods, our system contains single microchannel through which solutions are transported squeezed into calcium chloride solution. Ca2+ ions immediately cross link solution state that is collected rotor. We use microchannels to define...
Epigenetic alterations hold great promise as biomarkers for early stage cancer diagnosis. Nevertheless, direct identification of rare methylated DNA in the genome remains challenging. Here, we report an ultrasensitive framework nucleic acid-based electrochemical sensor quantitative and highly selective analysis methylation. Notably, can detect 160 fg million-fold unmethylated samples using this methylation-specific polymerase chain reaction (E-MSP) method. The high sensitivity E-MSP enables...
In this study, it is shown for the first time that a reduced graphene oxide (rGO) carrier has 20-fold higher catalysis rate than in Ag
Liver cancer (LC), one of the most common malignant primary tumors, presents a poor prognosis, high morbidity rate, and clinical outcomes. Despite conventional treatments have been applied prior to deterioration, their benefits were still limited. Arsenic trioxide (ATO), toxic Chinese medicine, has proven efficiently inhibit growth LC both in vitro vivo. However, its therapeutic effects are hindered by pharmacokinetics dose-limited toxicity. In this study, we developed pH-responsive...
Extracellular vesicles (EVs) are with lipid bilayer structures shed from the plasma membrane of cells. Microvesicles (MVs) a subset EVs containing proteins, lipids, nucleic acids, and other metabolites. MVs can be produced under specific cell stimulation conditions isolated by modern separation technology. Due to their tumor homing large volume, cell-derived microvesicles (TMVs) have attracted interest recently become excellent delivery carriers for therapeutic vaccines, imaging agents or...
Colorectal cancer (CRC) is a malignant epithelial tumor with high morbidity and mortality. In CRC treatment, irinotecan (CPT-11) as chemotherapeutic drug widely applied. However, its half-life short, leading to large dosages severe side effects. Red blood cells (RBCs) are biocompatible carriers capacity, avoiding premature degradation achieving slow release. Nanoalumina (AN) an emerging immune adjuvant that can enhance the response. Here, we used RBCs absorbed AN construct AN-CPT-11-RBCs....