A5044497119- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Sulfur Compounds in Biology
- Luminescence Properties of Advanced Materials
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Diabetes and associated disorders
- Photodynamic Therapy Research Studies
- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- CAR-T cell therapy research
- Molecular Sensors and Ion Detection
- Cancer Research and Treatments
- Diabetes Management and Research
- Silk-based biomaterials and applications
- Diverticular Disease and Complications
- Photoacoustic and Ultrasonic Imaging
- Electronic Packaging and Soldering Technologies
- Adipokines, Inflammation, and Metabolic Diseases
- Appendicitis Diagnosis and Management
- Metabolism and Genetic Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Extracellular vesicles in disease
The First People's Hospital of Changde
2018-2025
Hunan University
2023-2025
State Key Laboratory of Chemobiosensing and Chemometrics
2023-2024
Weatherford College
2023
Central South University
2023
Hunan Normal University
2018-2022
Guangxi Medical University
2022
Changsha Normal University
2022
Changsha University
2018
Kunming Institute of Precious Metals
2010
Near-infrared-II (NIR-II) imaging has emerged as a powerful technique for high-resolution visualization of deep anatomical features, benefiting from minimized autofluorescence, diminished optical scattering, and absorption tissue. However, the current synthesis NIR-II nanoprobes is time-consuming, labor-intensive process with low yields, highlighting need an efficient rapid approach instead. Herein, we report DNA-templated silver nanoclusters (Ag NCs) emission that can be rapidly synthesized...
Metformin as a hypoglycemic drug for antidiabetic treatment has emerged multipotential many disease treatments such cognitive disorders, cancers, promoting weight loss. However, overdose uptake may upregulate the hepatic H2S level, subsequently leading to serious liver injury and toxicity. Therefore, developing intelligent second near-infrared (NIR-II) emitting nanoprobes by using endogenous smart trigger noninvasive highly specific in situ monitoring of metformin-induced hepatotoxicity is...
Lanthanide based upconversion (UC) nanoprobes have emerged as promising agents for biological applications. Extending the excitation light to second near-infrared (NIR-II), instead of traditional 980/808 nm light, and realizing NIR-II responsive single-band red UC emission is highly demanded bioimaging application, which has not yet been explored. Here, a new type (1532 nm) nanoparticles (UCNPs) with enhanced controllable phase size designed by introducing Er3+ sensitizer utilizing Mn2+...
Gas-based therapy has emerged as a new green strategy for anti-tumor treatment. However, the therapeutic efficacy is still restricted by deep tissue controlled release, poor lymphocytic infiltration, and inherent immunosuppressive tumor microenvironment (TME). Herein, type of nanovaccine designed integrating low dose soft X-ray-triggered CO releasing lanthanide scintillator nanoparticles (ScNPs: NaLuF4 :Gd,Tb@NaLuF4 ) with photo-responsive moiety (PhotoCORM) synergistic gas/immuno-therapy...
Bones play vital roles in human health. Noninvasive visualization of the full extent bones is highly demanded to evaluate many bone-related diseases. Herein, we report poly (acrylic acid) (PAA)-modified NaLuF4:Yb/Er/Gd/Ce@NaYF4 nanoparticles (PAA-Er) with second near-infrared emission beyond 1500 nm (also referred as NIR-IIb) for high-resolution bone/bone marrow imaging and bone fracture diagnosis. The NIR-IIb optical-guided presents a high signal noise ratio, which superior that NIR-II...
Excessive production of hydrogen sulfide (H2 S) plays a crucial role in the progress colon cancer. Construction tumor-specific H2 S-activated smart nanoplatform with controllable biodegradation is great significance for precise and sustainable treatment Herein, an endogenous S triggered Co-doped polyoxometalate (POM-Co) cluster self-adjustable size, controlled biodegradation, cyclic depletion S/glutathione (GSH) designed synergistic enhanced photothermal chemodynamic therapy. The POM-Co...
Upconversion nanoparticles (UCNPs) emerged as promising near-infrared (NIR) light-triggered nanotransducers for photodynamic therapy (PDT). However, the traditionally used 980 nm excitation source could cause an overheating effect on biological tissues, and single photosensitizer (PS) loading not efficiently utilize multiradiation UC luminescence, resulting in a limited efficiency of PDT tumor tissues with hypoxia characteristics. Herein, 808 light-responsive Nd-sensitized UCNPs@mSiO2@MnO2...
PAA-KSc<sub>2</sub>F<sub>7</sub>nanoprobes with good biocompatibility and controlled size were developed for brain blood vessel fluorescence imaging beyond 1500 nm.
Overexpression of endogenous H2S is one the key characteristic in colon cancer. However, developing H2S-activated optical probes for specific diagnosis colorectal cancer rarely explored. Herein, an situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex intelligently lighting up was The designed Ag-CEW holds efficient NIR-II emission 1,000-1,400 nm via H2S-induced chemical reaction to form Ag2S quantum dots (QDs). After reaction,...
Although great achievements have been made in the past decades medicine, cancer remains a worldwide public health issue. Surgery is usually accompanied by shortcomings such as residual lesions and poor treatment effects, successive appearance of other methods, radiotherapy chemotherapy, has not changed postoperative recurrence rate, toxicity, side effects. However, advent photodynamic therapy greatly improved this situation. Photodynamic an emerging tumor diagnosis technology with good...
Combining photodynamic therapy (PDT) and immunotherapy has shown profound impact for synergistic treatment of malignant tumors. However, the shallow penetration depth traditional visible light activated PDT, immunosuppressive tumor microenvironment (TME), poor immunogenicity deep-seated solid tumors have significantly impeded therapeutic efficiency. Herein, a soft X-ray nanoprobe is rationally engineered via integrating porphyrin Zr-based metal-organic framework with lanthanide NaYF4...
In this study, it is shown for the first time that a reduced graphene oxide (rGO) carrier has 20-fold higher catalysis rate than in Ag
Abstract Lanthanide scintillators capable of converting the absorbed X‐ray photon energy to ultraviolet (UV) or visible light, are emerged as promising nanoprobes for multifunctional diagnosis and deep‐tissue antitumor therapy such X‐ray‐excited fluorescence (XEF) imaging, X‐ray‐triggered photodynamic (X‐PDT), soft X‐ray‐activated NO gas therapy. Such biomedical tools have potential overcome major challenge depth barrier suffered by traditional optics. Recently, various lanthanide been...
Abstract In recent years, PLGA micro/nano particle drug delivery systems has been widely used in cancer treatment. According to the unique properties of PLGA, carriers various structures are designed keep function drugs or bioactive substances, ensure effective load molecules and improve bioavailability diseased parts. is one earliest most commonly biodegradable materials. It often for functional modification with other polymers (such as polyethylene glycol chitosan) aptamers ligands)...
The rational construction of efficient hypoxia-tolerant nanocatalysts capable generating singlet oxygen (
Dual/multimodal imaging strategies are increasingly recognized for their potential to provide comprehensive diagnostic insights in cancer by harnessing complementary data. This study presents an innovative probe that capitalizes on the synergistic benefits of afterglow luminescence and magnetic resonance (MRI), effectively eliminating autofluorescence interference delivering a superior signal-to-noise ratio. Additionally, it facilitates deep tissue penetration enables noninvasive imaging....
An endogenous H2S-triggered intelligent optical nanoprobe combining second near-infrared (NIR-II) fluorescence with photoacoustic (PA) imaging can provide more comprehensive information to further improve the sensitivity and reliability of diagnosis for colorectal tumor, which is rarely explored. Herein, an SiO2@Ag was designed in situ dual-modal NIR-II/PA cancer. The be converted SiO2@Ag2S after biosynthesis via a sulfuration reaction over-expressed H2S tumor. More importantly, exhibits...
Silk fibroin-based materials spun by silkworms present excellent biocompatible and biodegradable properties, endowing them with broad applications for use in vivo implanted devices. Therefore, it is highly desirable to explore functionalized silk additional optical bioimaging abilities the direct situ monitoring of status devices vivo. Herein, a new type material second near-infrared (NIR-II, 1000-1700 nm) emission explored real-time observation biological stent model using general route...
Background Many studies have confirmed that lipid accumulation products (LAP) predict arterial stiffness (AS) in hypertensive patients. But there is little research on the use of LAP identifying early atherosclerosis patients with type 2 diabetes mellitus (T2DM). The aim this study was to determine relationship between index and brachial-ankle pulse wave velocity (baPWV) Chinese T2DM. Methods A total 1471 participants T2DM, ranging age from 18 80, were included cross-sectional study. BaPWV...