A5100601830- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- vaccines and immunoinformatics approaches
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Bone health and treatments
- Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Parathyroid Disorders and Treatments
- Circular RNAs in diseases
- Salivary Gland Disorders and Functions
- Pharmaceutical and Antibiotic Environmental Impacts
- Structural Engineering and Vibration Analysis
- Breast Lesions and Carcinomas
- Ferroptosis and cancer prognosis
- Photodynamic Therapy Research Studies
- Intracranial Aneurysms: Treatment and Complications
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
Feng Chia University
2025
Guangxi University of Chinese Medicine
2021-2024
Jiangsu Hengrui Medicine (China)
2023-2024
The University of Texas MD Anderson Cancer Center
2024
Guangxi University
2024
Nanjing Medical University
2011-2021
Wuxi People's Hospital
2021
Sun Yat-sen University Cancer Center
2019
Fudan University Shanghai Cancer Center
2019
Shanghai Medical College of Fudan University
2019
Although great achievements have been made in the past decades medicine, cancer remains a worldwide public health issue. Surgery is usually accompanied by shortcomings such as residual lesions and poor treatment effects, successive appearance of other methods, radiotherapy chemotherapy, has not changed postoperative recurrence rate, toxicity, side effects. However, advent photodynamic therapy greatly improved this situation. Photodynamic an emerging tumor diagnosis technology with good...
Recent research on transition metal oxides has shifted the paradigm toward development of diverse ternary phases in one-dimensional functional oxides. Among these, Zn-based have been prominent, with Zn2SiO4 materials being a crucial material. This study focuses nanotubes through meticulous solid reaction synthesis and their resistive random-access memory (RRAM) application. The surface morphology crystal structure systematically meticulously investigated by scanning electron microscopy...
Abstract Objectives Our aim was to identify and prevalidate a set of salivary proteins that can distinguish oral squamous cell carcinomas (OSCC) patients from healthy individuals with potentially malignant disorders (OPMD). Subjects methods Proteomes 60 saliva samples individuals, OPMD patients, OSCC were assayed using the isobaric tags for relative absolute quantitation (iTRAQ) method. Enzyme‐linked immunosorbent assay (ELISA) used candidate biomarkers in an independent sample ( n = 90)....
Adebrelimab, a novel anti-PD-L1 antibody, has been approved by the National Medical Products Administration of China as an intravenous infusion for use in combination with carboplatin and etoposide first-line treatment extensive-stage small-cell lung cancer 2023. A two-compartment model empirical time-varying CL adebrelimab was established based on data from 263 patients receiving body weight-based doses two clinical studies. Significant covariate effects baseline weight, albumin levels,...
Abstract Purpose: PD-1 blockade plus chemotherapy has become the new standard of care in patients with untreated advanced non–small cell lung cancer (NSCLC), whereas predictive biomarkers remain undetermined. Experimental Design: We integrated clinical, genomic, and survival data 427 NSCLC treated first-line or from two phase III trials (CameL CameL-sq) investigated prognostic value HLA class I evolutionary divergence (HED). Results: High HED could predict significantly improved objective...
The aim of this retrospective study was to investigate the risk factors for bone metastases (BM) in clinical T1N0 non-small cell lung cancer (NSCLC) patients. From January 2010 June 2012, 739 patients with primary diagnosed cT1N0 NSCLC were eligible study. Clinical variables, including sex, smoking history, age at diagnosis, tumor size, pathologic subtype, preoperative serum Carcino embryonie antigen (CEA) level, lesion imaging performance, and skeletal system symptom, collected. BM found 7...
Purpose: Endocrine therapy is one of the main treatment options for hormone receptor (HR)-positive advanced breast cancer (ABC). However, whether combination endocrine with chemotherapy practicable and more effective than alone remains unknown. The aim this study was to investigate clinical efficacy aromatase inhibitors (AIs) combined metronomic capecitabine provide evidence further research in patients HR-positive ABC. Methods: Data from 407 ABC were retrospectively analyzed. A total 305...
<h3>Background</h3> B7 homolog 3 (B7-H3/CD276) is a promising checkpoint target in advanced prostate cancer (PCa) due to its accumulation tumor lesions. However, the anti-tumor effects of B7-H3 mAb are neither fully unleashed nor satisfactory recent clinical trials and preclinical studies. <h3>Methods</h3> To determine pro-tumorigenesis role B7-H3, we generated cutting-edge genetically engineered mouse model (GEMM) by crossing <i>Cd276<sup>Loxp</sup></i> allele onto...
Purpose: The objective of this study was to analyze the safety and efficacy definitive chemoradiotherapy salvage chemotherapy in pancreatic cancer (PC) patients with isolated locoregional recurrence after radical resection assess factors associated tumor response. Patients methods: A retrospective recurrent PC who were treated at our institution between 2012 2017 conducted. Medium dose 56.0 Gy (range: 54.0 - 60.2 Gy) 1.8 2.15 daily fractions prescribed PTV-G 50.4 PTV-C. received before, same...
The aim of this study is to identify the prognostic significance X-ray cross-complementing gene 1 (XRCC1) in patients with gastric cancer undergoing surgery and platinum-based adjuvant chemotherapy.Immunohistochemistry (IHC) was used evaluate XRCC1 protein expression profiles on surgical specimens 612 patients. relationship between existing factors, chemotherapy, disease-free survival (DFS) overall (OS) were analyzed.Among staged Ⅱ/Ⅲ our study, 182 (29.74%) evaluated as IHC positive. not...
In an open-label, single-arm, multicenter phase II study, camrelizumab demonstrated promising efficacy as a second-line treatment in pre-treated advanced/metastatic NSCLC, with those exhibiting positive PD-L1 expression deriving greater benefit from (Yang et al., Cancer Immunol Immunother, 2021). Here we present updated analysis of and safety outcomes this study follow-up period approximately 5 years. Eligible patients had NSCLC previously received platinum-based doublet chemotherapy....
<p>Supplementary Materials</p>
<div>Abstract<p>Purpose: PD-1 blockade plus chemotherapy has become the new standard of care in patients with untreated advanced non-small-cell lung cancer (NSCLC), whereas predictive biomarkers remain undetermined. Patients and Methods: We integrated clinical, genomic survival data 427 NSCLC treated first-line or from two phase 3 trials (CameL CameL-sq) investigated prognostic value HLA class I evolutionary divergence (HED). Results: High HED could predict significantly improved...
<p>Supplementary Materials</p>
Hypercalcemia is a clinical emergency which can cause hypercalcemic crisis and even endanger patients' lives.The increase of serum calcium concentration caused by the redistribution in bone inhibition parathyroid secretion, known as non-parathyroid hypercalcemia.In this report, we presented rare case hypercalcemia during lactation order to optimize diagnosis treatment condition.A 27-year-old female patient was admitted Wuxi People's Hospital on July 11, 2019 due "fatigue, anorexia, pain both...
article: Predicting the prognosis of liver cancer patients based on cell differentiation trajectory and application nanomaterials in treatment - Minerva Surgery 2021 Dec 10 Medica Journals
<div>Abstract<p>Purpose: PD-1 blockade plus chemotherapy has become the new standard of care in patients with untreated advanced non-small-cell lung cancer (NSCLC), whereas predictive biomarkers remain undetermined. Patients and Methods: We integrated clinical, genomic survival data 427 NSCLC treated first-line or from two phase 3 trials (CameL CameL-sq) investigated prognostic value HLA class I evolutionary divergence (HED). Results: High HED could predict significantly improved...
<p>Supplementary Materials</p>