A5050621653- Oral Health Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Obesity, Physical Activity, Diet
- Autoimmune Bullous Skin Diseases
- Influenza Virus Research Studies
- Physical Activity and Health
- Diet, Metabolism, and Disease
- Respiratory viral infections research
- Oral and Maxillofacial Pathology
- Treatment of Major Depression
- Cancer, Lipids, and Metabolism
- Genetic Associations and Epidemiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tryptophan and brain disorders
- Cutaneous lymphoproliferative disorders research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Neurotransmitter Receptor Influence on Behavior
- Lipid metabolism and disorders
- RNA modifications and cancer
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
Shanghai Jiao Tong University
2018-2025
Nanjing Medical University
2016-2025
Shanghai Stomatological Hospital
2024-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2023-2025
Shanghai Mental Health Center
2018-2025
Nanchang University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Shangqiu First People's Hospital
2025
Hangzhou Women’s Hospital
2024
Jiangsu Province Hospital
2010-2023
Human infections of H5N1 highly pathogenic avian influenza virus have continued to occur in China without corresponding outbreaks poultry, and there is little conclusive evidence the source these infections. Seeking identify human infections, we sequenced 31 viruses isolated from humans (2005 2010). We found a number viral genotypes, not all which similar known counterparts. Guided by patient questionnaire data, also obtained environmental samples live poultry markets dwellings frequented...
ABSTRACT Four Caenorhabditis elegans genes, mes-2, mes-3, mes-4 and mes-6, are essential for normal proliferation viability of the germline. Mutations in these genes cause a maternal-effect sterile (i.e. mes) or grandchildless phenotype. We report that mes-6 gene is an unusual operon, second example this type operon C. elegans, encodes nematode homolog Extra sex combs, WD-40 protein Polycomb group Drosophila. mes-2 another (see paper by Holdeman, R., Nehrt, S. Strome, (1998). Development...
Control of gene expression at the translational level is crucial for many developmental processes. The mRNA cap-binding protein, eIF4E, a key player in regulation translation initiation; appropriate levels eIF4E are essential normal cell-cycle and tissue differentiation. observation that elevated during gametogenesis several organisms suggests might have specific role gamete formation as well. We show one five isoforms C. elegans IFE-1, enriched germline component germ granules (P granules)....
Abstract High quality is the main goal of today’s maize breeding and investigation grain traits would help to breed high-quality varieties in maize. In this study, genome-wide association studies a set 248 diverse inbred lines were performed with 83,057 single nucleotide polymorphisms (SNPs), five investigated environments for two years. The results showed that substantial natural variations these high broad-sense heritability. A total 49 SNPs found be significantly associated traits. Among...
Abstract Background Topical photodynamic therapy (PDT) has demonstrated encouraging results in the treatment of oral leukoplakia (OLK). However, data on clinical efficacy PDT Chinese patients with OLK are still limited. Methods Fifty diagnosed were enrolled, including various dysplastic tissues. All received topical 5-aminolevulinic acid (5-ALA) as a photosensitizer. Clinical was evaluated 4 weeks after treatment. Follow-up performed every 3 months during first year and 6 second year....
To explore the hypothesis that burning mouth syndrome (BMS) probably is a neuropathic pain condition, thermal and mechanical sensory thresholds were tested compared with age- gender-matched control participants using standardized battery of psychophysical techniques. Twenty-five BMS patients (men: 8, women: 17, age: 49.5 ± 11.4 years) 19 healthy included. The cold detection threshold (CDT), warm (WDT), (CPT), heat (HPT), (MDT) (MPT), in accordance German Network Neuropathic Pain guidelines,...
The specific etiology and pathogenesis of oral lichen planus (OLP) remain elusive, microbial dysbiosis may play an important role in OLP. We evaluated the saliva tissue bacterial community patients with OLP identified colonization bacteria tissues. (n = 60) 24) samples from healthy controls were characterized by 16S rDNA gene sequencing signals tissues detected fluorescence situ hybridization (FISH) targeting gene. Results indicate that microbiome was different microbiota saliva. Compared...
<b><i>Introduction:</i></b> Physical activity (PA), sedentary behaviors (SB), sleep, and diet are related to adiposity among children adolescents. However, there may be interactions between PA, SB, diet, these lifestyle work together affect body weight. The purpose of this study was explore the impact multiple on childhood (body mass index <i>z</i>-score overweight/obesity), investigate effect meeting guidelines adolescents in China....
Abstract Oral lichen planus (OLP) is a localized autoimmune disease of the oral mucosa, with an incidence up to 2%. Although corticosteroids are first-line treatment, they cause several adverse effects. Quercetin, naturally occurring compound, has fewer side-effects and provides long-term benefits. Besides, it powerful anti‑inflammatory activities. Here, we combined network pharmacology experimental verification predict verify key targets quercetin against OLP. First, 66 quercetin-OLP common...
Abstract Objectives Our aim was to identify and prevalidate a set of salivary proteins that can distinguish oral squamous cell carcinomas (OSCC) patients from healthy individuals with potentially malignant disorders (OPMD). Subjects methods Proteomes 60 saliva samples individuals, OPMD patients, OSCC were assayed using the isobaric tags for relative absolute quantitation (iTRAQ) method. Enzyme‐linked immunosorbent assay (ELISA) used candidate biomarkers in an independent sample ( n = 90)....
The calcined tooth powder (CTP), a type of allogeneic biomimetic mineralized material, has been confirmed that can promote new bone formation when obtained at high temperature. aim this study was to investigate effects the conditioned medium (CTP-CM) on osteogenic and odontogenic differentiation human dental pulp stem cells (hDPSCs) underlying mechanisms involved. First, ALP activity assay determined 200 μg/mL optimal concentration CTP-CM for following experiments. had no significant effect...
To investigate the association of sleep duration with overweight and obesity among children aged 6 to 17 years in China, 2010–2012 data from China National Nutrition Health Surveillance (CNHHS) were analyzed. A total 35,414 recruited survey. Body mass index (BMI) was converted into three categories: normal weight, obesity. In multinomial logistic regression model, divided four groups: very short, recommended long. restricted cubic splines (RCS), examined as a continuous variable relation...
<b><i>Abstract:</i></b> The aim of this study was to explore association physical activity and sitting time with overweight/obesity in Chinese occupational populations for the development intervention prevention strategies obesity. <b><i>Methods:</i></b> A total 23,112 participants were selected from 2010–2012 China National Nutrition Health Survey (CNNHS). logistics regression model used examine associations by gender after adjusting age,...
Abstract While non-alcoholic fatty liver disease (NAFLD) has been widely studied, the pathophysiology of lean NAFLD, critical NAFLD subgroup, remains elusive. This study aimed to clarify association between polymorphisms GCKR , waist circumference, and odds in elderly Chinese Han population who live Zhangjiang community center Shanghai, China. Three single nucleotide (SNPs), including rs1260326, rs780093, rs780094, were genotyped MassARRAY Analyzer. The SNPs with circumference five genetic...
ABSTRACT Aims The challenges in identifying functional variants from genome‐wide association studies (GWAS) and unraveling regulatory mechanisms schizophrenia research persist, particularly intronic regions. A non‐coding variant, rs1399178, associated with risk, is identified its impact on NRF1 binding investigated. Methods This study focuses GWAS risk loci, using genomics, expression analyses structural analysis to identify 736 single‐nucleotide polymorphisms (SNPs) that disrupt...
Infantile spasms syndrome (ISS) is an early-onset epileptic encephalopathy characterized by uncontrollable seizures, severe electroencephalogram abnormalities, as well delayed cognitive and behavioral development. Independent studies have shown that a variety of genes are involved in ISS genetic factors play critical role its pathogenesis. Here we report two de novo mutations the casein kinase 1 isoform alpha (CSNK1A1) gene which underlie epilepsy with similar clinical presentation patients....
Microbial dysbiosis links to mucosal immune dysregulation, but the specific bacterial contributions oral inflammation remain unclear. Escherichia coli (E. coli), a pathogen well-characterized in immunity and regulation studies, has been observed be enriched chronic inflammatory lesions was reported modulate T helper 17 cells (Th17)/T regulatory (Treg) homeostasis. Here, we developed an mucositis mouse model via tongue scratch E. topical application investigate its role Th17/Treg imbalance....
Human trophoblastic cell-surface antigen 2 (TROP2) is a cell surface glycoprotein that exhibits high expression in various carcinomas but low or no normal tissues. High TROP2 plays an important role promoting tumor development and aggressiveness, which correlated with reduced patient survival. However, there are few studies regarding relation to both oral squamous carcinoma (OSCC) potentially malignant lesions. The of protein mRNA was investigated OSCC tissues, lesion tissues using...