A5100609364- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone health and treatments
- Advanced Nanomaterials in Catalysis
- Connective tissue disorders research
- Endometrial and Cervical Cancer Treatments
- Advanced Neuroimaging Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Gastrointestinal Tumor Research and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Glycosylation and Glycoproteins Research
- Esophageal Cancer Research and Treatment
- Salivary Gland Disorders and Functions
- Renal cell carcinoma treatment
- Dermatological and Skeletal Disorders
Southwest Medical University
2025
Fudan University
2011-2025
Guangxi Medical University
2025
Lanzhou Veterinary Research Institute
2025
Chinese Academy of Agricultural Sciences
2025
Lanzhou University
2025
First Affiliated Hospital of Zhengzhou University
2021-2025
Huashan Hospital
2011-2025
Northwest A&F University
2025
Nanjing Drum Tower Hospital
2015-2024
Gold nanoparticles (AuNPs) with simultaneous plasmonic and biocatalytic properties provide a promising approach to developing versatile bioassays. However, the combination of AuNPs' intrinsic enzyme-mimicking their surface-enhanced Raman scattering (SERS) activities has yet be explored. Here we designed peroxidase-mimicking nanozyme by in situ growing AuNPs into highly porous thermally stable metal–organic framework called MIL-101. The obtained AuNPs@MIL-101 nanozymes acted as peroxidase...
Nanozymes, the nanostructures with enzymatic activities, have attracted considerable attention because, in comparison natural enzymes, they offer possibility of lowered cost, improved stability, and excellent recyclability. However, specificity catalytic activity current nanozymes are still far lower than that their counterparts, which turn has limited use such as bioanalysis. To address these challenges, herein we report design development integrated (INAzymes) by simultaneously embedding...
To investigate the prevalence of eight common rheumatic diseases in a large Chinese population.A population-based epidemiological investigation suburb Beijing was conducted 14 642 individuals. A community-based survey carried out using screening questionnaire. Positive responders were included clinical and laboratory examination. Diagnosis based on criteria ACR or those used widely literature.A total 10 556 inhabitants interviewed. Forty-three cases RA identified with an age-adjusted 0.28%...
Although ultrasmall metal nanoparticles (NPs) have been used as radiosensitizers to enhance the local damage tumor tissues while reducing injury surrounding organs, their rapid clearance from circulatory system and presence of hypoxia within continue hamper further application in radiotherapy (RT). In this study, we report a size tunable nanocluster bomb with initial approximately 33 nm featuring long half-life during blood circulation destructed release small microenvironment-targeting NPs...
W18O49-mediated photodynamic therapy (PDT) and photothermal (PTT) are limited by the easily oxidized property tumor hypoxia. Here, we report development of platelet membranes as nanocarriers to co-load W18O49 nanoparticles (NPs) metformin (PM-W18O49-Met NPs). Platelet can protect from oxidation immune evasion, increase accumulation in sites via passive EPR effect active adhesion between platelets cancer cells. The introduction (Met), a typical anti-diabetic drug, alleviate hypoxia through...
Abstract Lipid overload results in lipid redistribution among metabolic organs such as liver, adipose, and muscle; therefore, the interplay between liver other is important to maintain homeostasis. Here, we show that responds first sends hepatocyte-derived extracellular vesicles (EVs) targeting adipocytes regulate adipogenesis lipogenesis. Geranylgeranyl diphosphate synthase (Ggpps) expression enhanced by regulates EV secretion through Rab27A geranylgeranylation. Consistently, liver-specific...
Insufficient blood perfusion is one of the critical problems that hamper clinical application tissue engineering bone (TEB). Current methods for improving vessel distribution in TEB mainly rely on delivering exogenous angiogenic factors to promote proliferation, migration, differentiation, and formation endothelial cells (ECs) and/or progenitor (EPCs). However, obstacles including limited activity preservation, difficulty controlled release, high cost obstructed practical this strategy. In...
The consumption of oxygen in photodynamic therapy (PDT) significantly exacerbates the degree hypoxia tumors, which not only impedes therapeutic effect PDT, but also drives local tumor recurrence. To relieve PDT-induced and improve outcome PDT cancer treatment, herein we reported a class Bi2WO6 nanoparticles (NPs) as robust multifunctional platform, integrates abilities for contrast-enhanced computed tomography (CT) imaging, photothermal therapy, an oxygen-free manner. as-obtained NPs with...
Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis, which function mainly through an overall inhibition osteoclast. However, not all osteoclasts "bone eaters"; preosteoclasts (pOCs) play anabolic roles in formation angiogenesis coupling with osteoblasts secreting platelet derived growth factor-BB (PDGF-BB). In this study, a bone-targeted pH-responsive nanomaterial was designed selectively eliminating mature (mOCs) without affecting pOCs....
Abstract Molecular imaging‐guided precision photothermal therapy has shown tremendous potential for invasively thermal ablation with solid tumors. However, it is still a pressing clinical need to develop precise and deep‐tissue multi‐scale imaging technologies easily integrated into single system boost accurate treatments. Herein, SERS/NIR‐II optical nanoprobe assembled by gold nanostars, Raman molecular tags, silver sulfide quantum dots through silica bridges (named AuDAg 2 S) reported that...
There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) bone turnover markers in adults living Shanghai. The objectives were determine the prevalence insufficiency Shanghai investigate 25(OH)D with function markers. This cross-sectional study involved 649 men 1939 women aged 20–89 years who randomly sampled Serum concentrations 25(OH)D, PTH, albumin, measured. During winter season, (<30 ng/mL) was 84% males 89% females. deficiency (<20 30%...
Activatable multimodal probes that show enhancement of multiplex imaging signals upon interaction with their specific molecular target have become powerful tools for rapid and precise biological processes. Herein, we report a stimuli-responsive disassembly approach to construct redox-activatable fluorescence/19F-MRS/1H-MRI triple-functional probe 1. The small molecule 1 itself has high propensity self-assemble into nanoparticles quenched fluorescence, attenuated 19F-MRS signal, 1H-MRI...
The development of agents for noninvasive photothermal/photodynamic therapies (PTT/PDT) against cancer remains challenging because most PTT cause side effects on normal tissues due to their high cytotoxicity and slow metabolism rate. We successfully synthesized an organic compound (C3), encapsulated in PEG-PCL with indocyanine green (ICG), form hybrid nanoparticles (PEG-PCL-C3-ICG NPs) use as a new PPT/PDT agent treat single irradiation. Compared conventional PPT agents, such Au nanorods, C3...
The combination of W18O49 and tirapazamine (TPZ) core has been first introduced into the preparation poly(ε-caprolactone)–poly(ethylene glycol) (PL) surrounded nanoparticles (NPs). aim using is employing its capability reacting with absorbed O2 to generate reactive oxygen species (ROS) when exposed a long-wavelength laser at 808 nm increase skin penetration body tolerance. In this work, we have demonstrated that unit gives rise more hypoxic tumor microenvironment activates prodrug TPZ...
γ-Glutamyl transpeptidase (GGT) is a cell-membrane-bound enzyme that involved in various physiological and pathological processes regarded as potential biomarker for many malignant tumors, precise detection of which useful early cancer diagnosis. Herein, new GGT-activatable near-infrared (NIR) fluorescence imaging probe (GANP) by linking GGT-recognitive substrate γ-glutamate (γ-Glu) NIR merocyanine fluorophore (mCy-Cl) with self-immolative linker p-aminobenzyl alcohol (PABA) reported. GANP...