A5048599738- Gastrointestinal Tumor Research and Treatment
- Bone Metabolism and Diseases
- Mechanisms of cancer metastasis
- Advanced battery technologies research
- Electrocatalysts for Energy Conversion
- RNA modifications and cancer
- Supercapacitor Materials and Fabrication
- Renal cell carcinoma treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metalloenzymes and iron-sulfur proteins
- Catalytic Processes in Materials Science
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Sarcoma Diagnosis and Treatment
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Catalysts for Methane Reforming
- Advanced Photocatalysis Techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Advancements in Battery Materials
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
Weifang University
2022-2025
Peking Union Medical College Hospital
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Huazhong Agricultural University
2011-2025
Zhujiang Hospital
2023-2025
Southern Medical University
2023-2025
Wen's Food Group (China)
2020-2024
China Three Gorges University
2023-2024
Southeast University
2021-2024
First Affiliated Hospital of Chinese PLA General Hospital
2024
Abstract Bone is a dynamic organ continuously undergoing shaping, repairing and remodeling. The homeostasis of bone maintained by the balance between osteoblastic formation osteoclastic resorption. Osteoclasts (OCs) are specialized multinucleated cells derived from hematopoietic stem (HSCs) or monocytes/macrophage progenitor cells. There different stages during osteoclastogenesis, one most important steps to form functional osteoclasts realized cell-cell fusion. In our study, microarray was...
Abstract Nickel-based hydroxide hierarchical nanoarrays (Ni y M(OH) x HNAs M = Fe or Zn) are doped with non-noble transition metals to create nanostructures and regulate their activities for the oxygen evolution reaction. Catalytic performance in these materials depends on chemical composition presence of nanostructures. These novel contain small secondary nanosheets that grown primary nanowire arrays, providing a higher surface area more efficient mass transport electrochemical reactions....
ABSTRACT In this study, for the first time we discovered that M1/M2 macrophage phenotype ratio is increased in bone marrow of ovariectomized (OVX) osteoporotic C57BL/6 mice. Considering estrogen main variable, assumed participated alteration. To determine whether and how contributes to change ratio, isolated macrophages (BMMs) from mice femur stimulated cells with lipopolysaccharide (LPS)/interferon γ (IFN-γ) M1 polarization interleukin 4 (IL-4)/IL-13 M2 polarization. were then exposed RANKL...
Insufficient blood perfusion is one of the critical problems that hamper clinical application tissue engineering bone (TEB). Current methods for improving vessel distribution in TEB mainly rely on delivering exogenous angiogenic factors to promote proliferation, migration, differentiation, and formation endothelial cells (ECs) and/or progenitor (EPCs). However, obstacles including limited activity preservation, difficulty controlled release, high cost obstructed practical this strategy. In...
Abstract The objective of this study is to design a graphene‐based miRNA transfection drug delivery system for antiresorptive therapy. An efficient nonviral gene developed using polyethylenimine (PEI) functionalized graphene oxide (GO) complex loaded with miR‐7b overexpression plasmid. GO‐PEI exhibits excellent efficiency within the acceptable range cytotoxicity. after GO‐PEI‐miR‐7b significantly abrogates osteoclast (OC) fusion and bone resorption activity by hampering expression an...
By employing a tricarboxylate ligand 1-(4-carboxybenzyl)-1H-pyrazole-3,5-dicarboxylic acid (H3L), four lanthanide metal–organic frameworks (Ln-MOFs) formulated as {[LnL(H2O)2]·H2O}n (Ln = Eu, 1; Gd, 2; Tb, 3; Dy, 4) have been prepared under hydrothermal conditions. Single-crystal X-ray analyses reveal that compounds 1–4 are isomorphous and exhibit three-dimensional network structure featuring one-dimensional rectangular channel with size of ca. 7.8 Å × 12.1 along the b axis. The framework...
Highly efficient low-cost electrocatalysts for water splitting have attracted increasing interest in the development of energy storage and conversion. Here, we utilized copper (Cu) weaving mesh to situ fabricate earth-abundant elements-based integrated electrodes high performance splitting, where NiFe layered double hydroxide (NiFe-LDH) ultrathin nanoarrys oxygen evolution reaction (OER) Cu3P nanowires hydrogen (HER) were successfully constructed on Cu mesh. Notably, large stable current...
Apomixis, or asexual seed formation, is prevalent in Citrinae via a mechanism termed nucellar adventitious embryony. Here, multiple embryos of maternal genotype form directly from cells the ovule and can outcompete developing zygotic embryo as they utilize sexually derived endosperm for growth. Whilst embryony enables propagation clonal plants genetic constitution, it also barrier to effective breeding through hybridization. To address genetics evolution apomixis Citrinae, chromosome-level...
The catalyst layers (CLs) electrode is the key component of membrane assembly (MEA) in proton exchange fuel cells (PEMFCs). Conventional electrodes for PEMFCs are composed carbon-supported, ionomer, and Pt nanoparticles, all immersed together sprayed with a micron-level thickness CLs. They have performance trade-off where increasing loading leads to higher abundant triple-phase boundary areas but increases cost. Major challenges must be overcome before realizing its wide commercialization....
Completely repairing of damaged cartilage is a difficult procedure. In recent years, the use tissue engineering approach in which scaffolds play vital role to regenerate has become new research field. Investigating advances biological been regarded as main direction and great significance for construction artificial cartilage. Native materials synthetic polymeric have their advantages disadvantages. The disadvantages can be overcome through either physical modification or biochemical...
A multi-stimuli-responsive luminescent Ln-MOF (<bold>1</bold>), with a combination of exceptionally high thermal, air and chemical stabilities, as turn-on/turn-off chemosensor for metal ions small organic molecules is reported.
Abstract Photoelectrochemical (PEC) water splitting on illuminated semiconductors plays an increasing role in alternative energy devices because of the need for clean and sustainable energy. However, overall efficiency process is still very low requires further improvement widespread application. Herein, we report that PEC performance WO 3 can be optimized by constructing a @α‐Fe 2 O heterojunction nanosheet array to expand spectral range light absorption promote photogenerated electron–hole...
Development of emerging technologies for the harmless treatment and resource utilization sewage is an urgent demand both environment energy concerns. This work presents enhanced electrochemical hydrogen generation process from urea by coupling oxidation reaction (UOR) evolution (HER) under catalysis nanoporous nickel–iron (NP-NiFe)-based catalysts. The porous structure at nanoscale facilitates electrocatalysis through exposure access more active sites as well improving mass transfer....
Abstract Flexible Li‐air batteries (LABs) have been considered as promising power sources for wearable electronics owing to its higher energy density. However, when operated in ambient air, problems arise, such Li anode passivation, poor cycle life well leakage of liquid electrolyte. Herein, we present a LAB with tetraethylene glycol dimethyl ether (TEGDME, G4) gel electrolyte, which the is formed situ through cross‐linking reaction between G4 and lithium ethylenediamine (LiEDA) grown on...
The recombination loss of photo-carriers in photocatalytic systems fatally determines the energy conversion efficiency photocatalysts. In this work, an electrostatic field was used to inhibit photocatalysts by separating photo-holes and photo-electrons space. As a model structure, (010) facet-exposed BiVO4 nanowires were grown on PDMS-insulated piezo-substrate piezoelectric transducer (PZT). PZT substrate will generate under certain stress, behavior is influenced field. Our results showed...
Conductive 2D conjugated metal-organic frameworks (c-MOFs) are attractive electrode materials due to their high intrinsic electrical conductivities, large specific surface area, and abundant unsaturated bonds/functional groups. However, the c-MOFs reported so far have limited charge storage capacity during electrochemical charging discharging, energy density is still unsatisfactory. In this work, a strategy of selective center expand traditional electrode-electrolyte coupled system with...