A5052463284- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Antimicrobial Peptides and Activities
- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Insect and Pesticide Research
- HER2/EGFR in Cancer Research
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Wnt/β-catenin signaling in development and cancer
- Plant and animal studies
- Cancer-related Molecular Pathways
- Insect and Arachnid Ecology and Behavior
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- S100 Proteins and Annexins
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Plant Gene Expression Analysis
- CAR-T cell therapy research
Baylor College of Medicine
2018-2025
Breast Center
2024-2025
Northwest A&F University
2023-2025
Fudan University
2023
Harbin Institute of Technology
2023
Jiangxi University of Traditional Chinese Medicine
2021
Children's Cancer Center
2021
New Jersey Institute of Technology
2020
Beijing Jiaotong University
2020
Chinese Academy of Agricultural Sciences
2011-2019
Host defense peptides (HDPs) constitute a large group of natural broad-spectrum antimicrobials and an important first line immunity in virtually all forms life. Specific augmentation synthesis endogenous HDPs may represent promising antibiotic-alternative approach to disease control. In this study, we tested the hypothesis that exogenous administration butyrate, major type short-chain fatty acids derived from bacterial fermentation undigested dietary fiber, is capable inducing enhancing...
Metastasis has been considered as the terminal step of tumor progression. However, recent genomic studies suggest that many metastases are initiated by further spread other metastases. Nevertheless, corresponding pre-clinical models lacking, and underlying mechanisms elusive. Using several approaches, including parabiosis an evolving barcode system, we demonstrated bone microenvironment facilitates breast prostate cancer cells to metastasize establish multi-organ secondary We uncovered this...
Routine use of antibiotics at subtherapeutic levels in animal feed drives the emergence antimicrobial resistance. Development antibiotic-alternative approaches to disease control and prevention for food animals is imperatively needed. Previously, we showed that butyrate, a major species short-chain fatty acids (SCFAs) fermented from undigested fiber by intestinal microflora, potent inducer endogenous host defense peptide (HDP) genes chicken (PLoS One 2011, 6: e27225). In present study,...
Dietary modulation of the synthesis endogenous host defense peptides (HDPs) represents a novel antimicrobial approach for disease control and prevention, particularly against antibiotic-resistant infections. However, HDP regulation by dietary compounds such as butyrate is species-dependent. To examine whether could induce expression in pigs, we evaluated expressions panel porcine HDPs IPEC-J2 intestinal epithelial cells, 3D4/31 macrophages, primary monocytes response to sodium treatment...
Abstract Newcastle disease virus (NDV) causes severe infectious in poultry and selectively kills tumor cells, by inducing apoptosis cytokines secretion. In this report, we study the mechanisms underlying NDV-induced investigating unfolded protein response (UPR). We found that NDV infection activated all three branches of UPR signaling (PERK-eIF2α, ATF6, IRE1α) triggered apoptosis, avian cells (DF-1 CEF) various human cancer cell types (HeLa, Cal27, HN13, A549, H1299, Huh7, HepG2)....
Heterogeneous peroxymonosulfate (PMS) treatment is recognized as an effective advanced oxidation process (AOP) for the of organic contaminants. Quantitative structure–activity relationship (QSAR) models have been applied to predict reaction rates contaminants in homogeneous PMS systems but are seldom heterogeneous systems. Herein, we established QSAR updated with density functional theory (DFT) and machine learning approaches degradation performance a series We imported characteristics...
Cathelicidins are a major family of antimicrobial peptides present in vertebrate animals with potent microbicidal and immunomodulatory activities. Four cathelicidins, namely fowlicidins 1 to 3 cathelicidin B1, have been identified chickens. As first step understand their role early innate host defense chickens, we examined the tissue developmental expression patterns all four cathelicidins. Real-time PCR revealed an abundant cathelicidins throughout gastrointestinal, respiratory, urogenital...
ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development cancer. Conventionally, their biological functions have been associated regulating WNT signaling receptor ubiquitination degradation. However, our proteogenomic studies revealed EGFR as the protein most negatively correlated ZNRF3/RNF43 mRNA levels multiple human cancers. Through biochemical investigations, we demonstrate that interact via extracellular domains, leading to subsequent...
Abstract There are distinct cell subpopulations in normal epithelial tissue, including stem cells, progenitor and more differentiated all of which have been extensively studied for their susceptibility to tumorigenesis. However, cells usually progress through a precancerous lesion state before becoming full-blown tumor. Precancerous early lesions heterogeneous, the subset that is primary source eventual tumor remains largely unknown. By using mouse models tailored address this question, we...
CRISPR-Cas9 has been used successfully to introduce indels in somatic cells of rodents; however, precise editing single nucleotides hampered by limitations flexibility and efficiency. Here, we report technological modifications the vector system that now allows homology-directed repair-mediated any proto-oncogene murine tissues generate tumor models with high Somatic either
ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development cancer. Conventionally, their biological functions have been associated regulating WNT signaling receptor ubiquitination degradation. However, our proteogenomic studies revealed EGFR as the most negatively correlated protein
Abstract Leucine-rich repeat-containing G protein–coupled receptors 4, 5, and 6 (LGR4/5/6) play critical roles in development cancer. The widely accepted mechanism is that these proteins, together with their R-spondin ligands, stabilize Wnt receptors, thus potentiating signaling. Here we show LGR4 enhanced breast cancer cell metastasis even when signaling was deactivated pharmacologically or genetically. Furthermore, mutants cannot potentiate nevertheless promoted migration invasion vitro...
The optimal load capacity provides sustainable production and high quality in 'Fuji' apple production. Determining crop loads with simple affordable thinning method is critical for apple. We set different capacities on tree rootstocks evaluated their effects development, fruit yield quality. vigorous stock, dwarfing rootstock, interstock were 240, 90, 100 apples above 80 mm diameter, respectively. To explore the strategies of diverse agents (carbaryl, 6-BA, NAA, Metamitron) used tree, we...
Striking antibody evasion by emerging circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants drives the identification of broadly neutralizing antibodies (bNAbs). However, how a bNAb acquires increased neutralization breadth during evolution is still elusive. Here, we identify clonally related family from convalescent individual. One members, XG005, exhibits potent and broad activities against SARS-CoV-2 variants, while other members show significant reductions in...
Using culture-independent technique polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) and conventional culture techniques, ecological risk of transgenic maize pollen on gut bacteria the Chinese honeybee, Apis cerana cerana, was assessed. Honeybees were fed with Bt-transgenic pollen, non-transgenic near isoline linear cry1Ah gene (800 ng mL−1) supercoiled plasmid DNA under laboratory conditions. The DGGE profile showed that number bands varied from 10.7 to 14.7 per...
Abstract Current chemopreventive strategies require 3–5 years of continuous treatment and have the concerns significant side effects; therefore, new agents that shorter safer treatments are urgently needed. In this study, we developed a murine model breast cancer mimics human initiation is ideal for testing efficacy therapeutics. model, introduction lentivirus carrying PIK3CA gene mutant commonly found in cancers infects small number mammary cells, leading to atypia first then ductal...
ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development cancer. Conventionally, their biological functions have been associated regulating WNT signaling receptor ubiquitination degradation. However, our proteogenomic studies revealed EGFR as the most negatively correlated protein ZNRF3/RNF43 mRNA levels multiple human cancers. Through biochemical investigations, we demonstrate that interact via extracellular domains, leading to subsequent...