Kimberly Walker
A5062054939- Genomics and Rare Diseases
- Respiratory viral infections research
- Cancer Genomics and Diagnostics
- Influenza Virus Research Studies
- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- COVID-19 Clinical Research Studies
- Glioma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Brain Metastases and Treatment
- Viral Infections and Immunology Research
- Streptococcal Infections and Treatments
- COVID-19 epidemiological studies
- CRISPR and Genetic Engineering
- Genetics, Bioinformatics, and Biomedical Research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Lymphoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Migration, Health and Trauma
- Pharmacogenetics and Drug Metabolism
- Neuroendocrine Tumor Research Advances
- Viral-associated cancers and disorders
- Biomedical Text Mining and Ontologies
- Pharmaceutical studies and practices
Baylor College of Medicine
2015-2025
Baylor Genetics
2015-2024
University of Houston
2024
University of Kentucky
2024
University of Wisconsin–Milwaukee
2018-2022
Vanderbilt University Medical Center
2020-2021
Baylor Scott & White Health
2012-2021
Baylor Scott & White Medical Center - Temple
2017-2021
Texas Health Dallas
2021
University of Pittsburgh
2020
Abstract Comprehensively mapping the genetic basis of human disease across diverse individuals is a long-standing goal for field genetics 1–4 . The All Us Research Program longitudinal cohort study aiming to enrol group at least one million USA accelerate biomedical research and improve health 5,6 Here we describe programme’s genomics data release 245,388 clinical-grade genome sequences. This resource unique in its diversity as 77% participants are from communities that historically...
Abstract Disparities in data underlying clinical genomic interpretation is an acknowledged problem, but there a paucity of demonstrating it. The All Us Research Program collecting including whole-genome sequences, health records, and surveys for at least million participants with diverse ancestry access to healthcare, representing one the largest biomedical research repositories its kind. Here, we examine pathogenic likely variants that were identified cohort. European subgroup showed...
The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form group histopathologically heterogenous tumors. To evaluate the molecular features these tumors, 98 ampullary were evaluated and compared 44 distal bile duct 18 duodenal adenocarcinomas. Genomic analyses revealed mutations in WNT signaling pathway among half patients all three irrespective their origin histological morphology. These tumors characterized by high frequency inactivating ELF3, rate...
Multivalent influenza vaccine products provide protection against A(H1N1)pdm09, A(H3N2), and B lineage viruses. The 2018-2019 season in the United States included prolonged circulation of A(H1N1)pdm09 viruses well-matched to strain A(H3N2) viruses, majority which were mismatched vaccine. We estimated number vaccine-prevented influenza-associated illnesses, medical visits, hospitalizations, deaths for season.We used a mathematical model Monte Carlo algorithm estimate numbers 95% uncertainty...
Abstract Background The All of Us Research Program (AoURP, “the program”) is an initiative, sponsored by the National Institutes Health (NIH), that aims to enroll one million people (or more) across USA. Through repeated engagement participants, a research resource being created enable variety future observational and interventional studies. program has also committed genomic data generation returning important health-related information participants. Methods Whole-genome sequencing (WGS),...
Evidence establishing effectiveness of influenza vaccination for prevention severe illness is limited. The US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN) a multiyear test-negative case-control study initiated in 2015-2016 to estimate vaccine preventing hospitalization among adults.
To compare the sensitivity and specificity of recommended 2-step rapid antigen detection test (RADT) with confirmatory culture vs point-of-care (POC) polymerase chain reaction (PCR) Roche cobas® Liat® Strep A for group Streptococcus (GAS) in pediatric patients pharyngitis, to investigate impact these tests on antibiotic use a large clinic. This prospective, open-label study was conducted at single site during fall/winter 2016–2017. total 275 aged 3 18 years symptoms pharyngitis had...
The secretion of dopamine and serotonin is increased in cholangiocarcinoma, which has growth-promoting effects. Monoamine oxidase A (MAOA), the degradation enzyme dopamine, suppressed cholangiocarcinoma via an unknown mechanism. aims this study were to (i) correlate MAOA immunoreactivity with pathophysiological parameters (ii) determine mechanism by expression (iii) evaluate consequences restored cholangiocarcinoma. was assessed nonmalignant controls. control promoter hypermethylation...
BACKGROUND The detection of epidermal growth factor receptor (EGFR) mutations on small biopsy or fine‐needle aspiration samples is required to guide therapy in nonsmall cell lung cancer (NSCLC). In this study, the authors compared results from EGFR mutation testing both cytologic smears and surgical specimens also performance platforms using 2 different technologies (pyrosequencing real‐time polymerase chain reaction) for specimen types. METHODS Specimens 114 patients were divided into...
Liquid-based cytology continues to be utilized as an adjunct conventional in most Australian laboratories, even though a direct-to-vial ThinPrep protocol has been introduced many countries with established cervical screening programs. Manual of slides widely practiced for more than 10 years and the recent introduction Imaging System (TPI) reported being sensitive smear (CS) identification high-grade disease.We report our experience since its into routine gynecological service. 87,284 split...
Norovirus is the most common cause of sporadic gastroenteritis and outbreaks worldwide. The rapid identification norovirus has important implications for infection prevention measures may reduce need additional diagnostic testing. Xpert assay recently received FDA clearance detection differentiation genogroups I II (GI GII), which account vast majority infections. In this study, we evaluated performance with both fresh, prospectively collected (n = 914) frozen, archived 489) fecal specimens....
Nurses teach, work, and conduct research in an increasingly hostile sociopolitical climate where health inequities persist among marginalized communities. Current approaches to cultural competency do not adequately equip nurses address these complex factors risk perpetuating stereotypes discrimination. A theory-driven emancipatory approach will instead lead lasting change uphold the core nursing value of commitment social justice. This article explicates key tenets critical race,...
Abstract Background The All of Us Research Program ( ) is one the world’s largest sequencing efforts that will generate genetic data for over million individuals from diverse backgrounds. This historic megaproject create novel research platforms integrate an unprecedented amount with longitudinal health information. Here, we describe design Celeste , a resilient, open-source cloud architecture implementing genomics workflows has successfully analyzed petabytes participant genomic information...
Juvenile-onset cataracts are known among the Hutterites of North America. Despite being identified over 30 years ago, this autosomal recessive condition has not been mapped, and disease gene is unknown. We performed whole exome sequencing three Hutterite-type cataract trios follow-up genotyping mapping in four extended kindreds. Trio exomes enabled genome-wide autozygosity mapping, which localized to a 9.5-Mb region on chromosome 6p. This contained two candidate variants, LEMD2 c.T38G MUC21...
Yearly influenza immunization is recommended for immunocompromised (IC) individuals, although immune responses are lower than that the nonimmunocompromised and data on vaccine effectiveness (VE) in IC scarce. We evaluated VE against influenza-associated hospitalization among adults.We analyzed from adults ≥ 18 years hospitalized with acute respiratory illness (ARI) during 2017-2018 season at 10 hospitals United States. were identified using prespecified case definitions electronic medical...
The 2016-2017 and 2017-2018 influenza seasons were notable for the high number of hospitalizations A(H3N2) despite vaccine circulating strain match.We evaluated effectiveness (VE) against hospitalization in test-negative HAIVEN study. Nasal-throat swabs tested by quantitative reverse transcription polymerase chain reaction (RT-PCR) VE was determined based on odds vaccination generalized estimating equations. Vaccine-specific antibody measured a subset enrollees.A total 6129 adults enrolled...
Abstract Pharmacogenomics promises improved outcomes through individualized prescribing. However, the lack of diversity in studies impedes clinical translation and equitable application precision medicine. We evaluated frequencies PGx variants, predicted phenotypes, medication exposures using whole genome sequencing EHR data from nearly 100k diverse All Us Research Program participants. report 100% participants carried at least one pharmacogenomics variant all (99.13%) had a phenotype with...