A5076667369- Parathyroid Disorders and Treatments
- Bone health and treatments
- Neuroendocrine Tumor Research Advances
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Thyroid and Parathyroid Surgery
- Genetic Syndromes and Imprinting
- Pancreatitis Pathology and Treatment
- Pituitary Gland Disorders and Treatments
- Bone and Joint Diseases
- Medical Imaging and Pathology Studies
- Neuroblastoma Research and Treatments
- Fluoride Effects and Removal
- Patient-Provider Communication in Healthcare
- Medical Malpractice and Liability Issues
- Spinal Fractures and Fixation Techniques
- Adrenal Hormones and Disorders
- Pharmaceutical Practices and Patient Outcomes
- Sarcoidosis and Beryllium Toxicity Research
- Magnesium in Health and Disease
- Folate and B Vitamins Research
- Bone Tumor Diagnosis and Treatments
- Spine and Intervertebral Disc Pathology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Heterotopic Ossification and Related Conditions
Mayo Clinic in Arizona
2016-2025
Mayo Clinic
2013-2025
WinnMed
2013-2024
Mayo Clinic in Florida
2009-2016
University of Minnesota Rochester
1999-2013
Institute of Nutrition, Metabolism and Diabetes
2004-2011
University of Pisa
2011
Helen Hayes Hospital
2010
Columbia University
2010
Bone Health and Osteoporosis Foundation
2010
OBJECTIVE Hypoglycemia is a cause of significant morbidity among patients with diabetes and may be associated greater risk death. We conducted retrospective study to determine whether patient self-report severe hypoglycemia increased mortality. RESEARCH DESIGN AND METHODS Adult (N = 1,020) seen in specialty clinic between August 2005 July 2006 were questioned about frequency during preencounter interview; 7 lost follow-up excluded from analysis. Mild was defined as symptoms managed without...
We updated the incidence of primary hyperparathyroidism in Rochester, Minnesota. The lower rates previously noted persisted, whereas parathyroidectomies at our institution remained high. These data suggest an etiologic factor may be responsible for peak 1970s.Automated serum calcium measurements were associated with a dramatic rise early 1970s, but progressive decline thereafter was unexpected and suggested fundamental change epidemiology disease. Our objective to evaluate trends since...
While severe primary hyperparathyroidism (HPT) is clearly associated with osteitis fibrosa cystica, it remains uncertain whether mild, asymptomatic HPT adversely affects the skeleton. Thus, we assessed incidence of age-related fractures in a large, population-based inception cohort 407 cases (93 men and 314 women) recognized during 28-year period, 1965-1992. Fracture risk was by comparing new at each site to number expected from gender- age-specific fracture rates for general population...
Wermers, Robert A.; Fatourechi, Vahab; Wynne, Alan G.; Kvols, Larry K.; Lloyd, Ricardo V. Author Information
Background: The introduction of routine measurement serum calcium levels led to a sharp increase in the incidence primary hyperparathyroidism early 1970s. Objective: To evaluate trends since mid-1970s. Setting: Rochester and Olmsted County, Minnesota. Design: Population-based descriptive study. Patients: All residents Rochester, Minnesota, who received an initial diagnosis between 1965 1992 were identified through medical records linkage system Epidemiology Project. Included as persons...
Objective: The aim of the study was to assess adding vs. switching teriparatide 20μg/d in patients on alendronate or raloxifene. Design: We conducted a randomized, open-label trial. Patients and Interventions: Postmenopausal women with osteoporosis raloxifene for at least 18 months added (Add groups) switched (Switch months. Main Outcome Measures: measured bone turnover markers (BTM) mineral density (BMD). Results: In stratum, increases BTM were smaller Add Switch group [6-month PINP (64...
We describe a heart transplant patient with painful periostitis and exostoses who was receiving long-term therapy voriconazole, which is fluoride-containing medication. Elevated plasma bone fluoride levels were identified. Discontinuation of voriconazole led to improvement in pain reduced alkaline phosphatase levels.To determine whether cause excess, we measured 10 adult post-transplant patients had received for at least 6 months did not receive voriconazole. To assess the effect renal...
The association between acute pancreatitis and primary hyperparathyroidism (PHPT) is controversial.The aim of the study was to address incidence disease characteristics in PHPT from a large inception cohort community residents.Patients with were identified an Olmsted County, Minnesota, subjects diagnosed 1965-2001 compared matched control subjects.The estimated rate developing calculated by person-years method. Cox models assessed effect status on development pancreatitis.Of 684 patients...
ABSTRACT Many postmenopausal women treated with teriparatide for osteoporosis have previously received antiresorptive therapy. In alendronate (ALN) or raloxifene (RLX), adding versus switching to produced different responses in areal bone mineral density (aBMD) and biochemistry; the effects of these approaches on volumetric BMD (vBMD) strength are unknown. this study, receiving ALN 70 mg/week (n = 91) RLX 60 mg/day 77) ≥18 months were randomly assigned add switch 20 µg/day. Quantitative...
Purpose Osteoporosis Choice, an encounter decision aid, can engage patients and clinicians in shared making about osteoporosis treatment. Its effectiveness compared to the routine provision of patient's estimated risk fracture using FRAX calculator is unknown. Methods Patient-level, randomized, three-arm trial enrolling women over 50 with osteopenia or eligible for treatment bisphosphonates, where use Choice was only usual care determine impact on patient knowledge, decisional conflict,...
Thiazide diuretics, the antihypertensive agent prescribed most frequently worldwide, are commonly associated with hypercalcemia. However, epidemiology and clinical features poorly understood.To update incidence of thiazide-associated hypercalcemia clarify its features.In a population-based descriptive study, Olmsted County, Minnesota, residents were identified through Rochester Epidemiology Project Mayo Clinic Laboratory Information System from 2002-2010 added to historical cohort beginning...
Abstract Introduction: Limited information is available about the clinical features of Paget's disease bone among unselected patients in community. We examined morbidity and mortality associated with this condition a large inception cohort Olmsted County, MN, residents new diagnosis from 1950 through 1994. Materials Methods: Survival was estimated using Kaplan-Meier method. Cox proportional hazards models were used to assess impact various covariates on death. Results: diagnosed 236 County...
Patients with primary hyperparathyroidism (PHP) often report nonspecific symptoms including mood disturbances.The objective of the study was to determine frequency depression in PHP and assess its response parathyroidectomy.A case-control at a referral center Rochester, MN, performed Patient Health Questionnaire-9 (PHQ-9) assessments observed (n = 81) surgical 88) benign nontoxic thyroid disease 85) baseline 1, 3, 6, 12 months after surgery or initial questionnaire PHP. Baseline PHQ-9 scores...