A5100411085- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Immunotherapy and Immune Responses
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Colorectal and Anal Carcinomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Intraperitoneal and Appendiceal Malignancies
- HER2/EGFR in Cancer Research
- Pregnancy and preeclampsia studies
- Lung Cancer Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Birth, Development, and Health
- MRI in cancer diagnosis
Chinese PLA General Hospital
2025
Nankai University
2025
Hubei University Of Economics
2025
Wuhan Third Hospital
2024
Tongren Hospital
2024
Fujian Medical University
2014-2024
Columbia University
2015-2024
Shenzhen University
2024
Union Hospital
2008-2024
Fujian Provincial Cancer Hospital
2009-2023
Despite the lack of efficacy data, robotic-assisted surgery has diffused rapidly into practice. Marketing to physicians, hospitals, and patients been widespread, but how this marketing contributed diffusion technology remains unknown.To examine effect regional hospital competition financial status on use for 5 commonly performed procedures.A cohort study 221 637 who underwent radical prostatectomy, total nephrectomy, partial hysterectomy, or oophorectomy at 1370 hospitals in United States...
Neoantigens are ideal targets for dendritic cell (DC) vaccines. So far, only a few neoantigen-based DC vaccines have been investigated in clinical trials. Here, we reported case of patient with metastatic gastric cancer who received personalized neoantigen-loaded monocyte-derived (Neo-MoDC) followed by combination therapy the Neo-MoDC and immune checkpoint inhibitor (ICI). The developed T responses against neoantigens after receiving vaccine alone. following triggered stronger response...
Vascular cognitive impairment and dementia (VCID) is the second most common form of after Alzheimer's disease (AD). Currently, mechanistic insights into evolution progression VCID remain elusive. White matter change represents an invariant feature. Compelling clinical neuroimaging pathological evidence suggest a link between white changes neurodegeneration. Our prior study detected hypoperfused lesions in mice with partial deficiency endothelial nitric oxide (eNOS) at very young age,...
Anti-programmed cell death-1 monotherapy is part of standard therapy for cutaneous melanoma but has low efficacy in mucosal melanoma. We evaluated the and safety atezolizumab plus bevacizumab as first-line advanced melanoma.This multicenter, open-label, single-arm, phase II study used a Simon's two-stage design. Atezolizumab (fixed-dose, 1,200 mg) (7.5 mg/kg) were administered by intravenous infusion every 3 weeks. The primary endpoint was objective response rate (ORR), determined per RECIST...
Abstract Background HL-085 is a selective, orally administered MEK1/2 inhibitor. We aimed to evaluate the safety and efficacy of in patients with advanced melanoma harboring NRAS mutations. Methods This was multicenter phase 1 study. twice daily standard 3 + dose-escalation design (10 dose cohorts; 0.5–18 mg daily), followed by expansion at recommended II (RP2D). The primary endpoints included tolerability, dose-limiting toxicity (DLT), maximum tolerated (MTD) RP2D. Results Between September...
The successful generation of T cell-mediated immunity for the treatment cancer has been a major focal point research. One critical strategies immunotherapy is to efficiently activate antigen-specific CD8 cells in immunosuppressive tumor environment. Here, we used transgenic OT-I/CD45.2/Rag-/- mice as source effector determine whether irradiation combined with adoptive cell transfer therapy could improve proliferation and function murine models. Local showed synergistic effect on growth...
OBJECTIVE To investigate risk factors of lymph node metastasis (LNM) in early gastric carcinoma (EGC) four tertiary medical centers Jiangsu Province, China. METHODS Among 10 097 consecutive combined cancer radical resections, 1903 EGC were identified and reviewed, 283 excluded 1620 included the study. All pathological some endoscopic reports reviewed for patients’ characteristics, tumor location, gross features, number nodes retrieved involved. Two pathologists independently investigated...
Purpose To explore the role of whole‐volume apparent diffusion coefficient (ADC)‐based entropy parameters in preoperative assessment gastric cancer's aggressiveness. Materials and Methods In all, 64 patients with cancers who underwent 3.0T magnetic resonance imaging (MRI) were retrospectively included. Regions interest drawn manually using in‐house software, around cancer lesions on each slice diffusion‐weighted images ADC maps. Entropy‐related based maps calculated automatically: (1)...
Whole-lesion apparent diffusion coefficient (ADC) histogram analysis has been introduced and proved effective in assessment of multiple tumors. However, the application whole-volume ADC gastrointestinal tumors just started never reported T N staging gastric cancers. Eighty patients with pathologically confirmed carcinomas underwent weighted (DW) magnetic resonance imaging before surgery prospectively. was performed by two radiologists independently. The differences parameters among different...
Although abscopal tumor regression remains a rare phenomenon, interest in exploiting how radiation stimulates the immune system to induce systemic response is increasing. Here, we tested hypothesis that immunogenicity determined ability of radiotherapy effects. We established highly (MC-38 and E.G7-OVA) or poorly (LL/2 B16-F10) immunogenic models this study treated them with sham radiation, single dose 15 Gy, three fractions 5 Gy on consecutive days. Alterations microenvironment after were...
Understanding the genetic basis of gene expression can shed light on regulatory mechanisms underlying complex traits and diseases. Single-cell resolved measures RNA levels single-cell quantitative trait loci (sc-eQTLs) have revealed regulation that drives sub-tissue cell states types across diverse human tissues. Here, we describe first phase TenK10K, largest-to-date dataset matched whole-genome sequencing (WGS) RNA-sequencing (scRNA-seq). We leverage scRNA-seq data from over 5 million cells...
Functional magnetic resonance imaging (fMRI) has emerged as a transformative tool in analyzing and understanding brain diseases. It is challenge to learn effective features from the high-dimensional fMRI. Most studies have focused on extracting connectivity-based for disease analysis. However, they heavily rely software toolboxes construct features, which may suffer large errors because of different manual parameter settings thus lead bad performance disorder A novel denoiser model proposed...
Objective To assess associations between napping and night-time sleep duration with impaired glucose regulation, insulin resistance (IR) glycated haemoglobin (HbA1c). Design Cross-sectional study. Setting Fujian Province, China, from June 2011 to January 2012. Participants This study enrolled 9028 participants aged 40–65 years. Data of 7568 no diabetes were included for analysis. Type 2 was defined applying WHO criteria. Outcome measures Participants’ daytime data collected using a...
Compared with early gastric intramucosal carcinoma, submucosal carcinoma is known to have a higher risk for lymph node metastasis (LMN), but factors in remain elusive. In this multicenter study 621 radical gastrectomies we investigated tumor budding and other of LMN that were identified 172 cases (27.7%). Overall, independent high-risk included lymphovascular invasion (odds ratio, 3.9; 95% confidence interval, 2.5-6.1), 3.3; 1.9-5.9), mixed tubular/papillary adenocarcinoma poorly cohesive...