A5049049912- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Gastrointestinal motility and disorders
- Myofascial pain diagnosis and treatment
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Infrared Thermography in Medicine
- Complementary and Alternative Medicine Studies
- Liver physiology and pathology
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Organ Transplantation Techniques and Outcomes
- Biofield Effects and Biophysics
- Thermoregulation and physiological responses
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Laser Applications in Dentistry and Medicine
- Infant Health and Development
- Neurological Disease Mechanisms and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Diet and metabolism studies
- Natural Antidiabetic Agents Studies
Affiliated Hospital of Guizhou Medical University
2024-2025
Guiyang Medical University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Beijing Hospital
2023-2024
National Center for Clinical Laboratories
2023-2024
Hong Kong Baptist University
2015-2024
Henan Cancer Hospital
2024
Zhengzhou University
2024
Jiangsu Frontier Electric Technology Co., Ltd. (China)
2023-2024
Nanjing Institute of Railway Technology
2023-2024
An excess of fecal bile acids (BAs) is thought to be one the mechanisms for diarrhea-predominant irritable bowel syndrome (IBS-D). However, factors causing excessive BA excretion remain incompletely studied. Given importance gut microbiota in metabolism, we hypothesized that dysbiosis might contribute IBS-D. By performing BA-related metabolic and metagenomic analyses 290 IBS-D patients 89 healthy volunteers, found 24.5% exhibited total BAs alteration BA-transforming bacteria feces. Notably,...
The gut microbiota is closely associated with gastrointestinal (GI) motility disorder, but the mechanism(s) by which bacteria interact and affect host GI remains unclear. In this study, through using metabolomic metagenomic analyses, an animal model of neonatal maternal separation (NMS) characterized accelerated colonic dysbiosis was used to investigate mechanism underlying microbiota-driven dysfunction. An excess intracolonic saturated long-chain fatty acids (SLCFAs) enhanced bowel in NMS...
Abstract Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, IBS-specific microbiota, metabolites, their interactions remain poorly understood. To address this issue, we performed metabolomic metagenomic profiling stool serum samples based on discovery (n = 330) validation 101)...
Abstract Background Altered patterns of bile acids (BAs) are frequently present in liver fibrosis, and BAs function as signaling molecules to initiate inflammatory responses. Therefore, this study was conducted uncover the notably altered components explore pathway BA induced inflammation development fibrosis. Methods Bile were quantified by ultraperformance liquid chromatography coupled mass spectrometry (UPLC‒MS/MS). Cell Counting Kit-8 assays used determine proliferative capacity HSCs....
11 potential α-glucosidase inhibitors in leaves of<italic>Cyclocarya paliurus</italic>were quickly identified by UF-UPLC-Q/TOF-MS/MS, and their inhibitory activities were verified<italic>in vitro</italic>and<italic>in vivo</italic>, as well docked with homology model.
Widespread invasiveness, represented by the invasion and migration, is most important characteristic of glioblastoma multiforme (GBM) main reason for therapeutic failure recurrence tumor. Hypoxia one microenvironment in determining tumor invasiveness. Therefore, intense efforts aimed at improved therapeutics are ongoing to demonstrate molecular mechanisms governing GBM migration invasion. This study aims explore role phosphatidylinositol 3-kinase/protein kinase B/mammalian target rapamycin...
Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types inflammatory bowel disease (IBD), that causes inflammation and ulcers colon. To investigate effect magnolol dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated 2% DSS drinking water for 5 consecutive days followed by intragastric administration (5, 10 15 mg/kg) daily 7 days. The results showed significantly attenuated index,...
Abstract A novel neuropeptide spexin was found to be broadly expressed in various endocrine and nervous tissues while little is known about its functions. This study investigated the role of bowel movement underlying mechanisms. In functional constipation (FC) patients, serum levels were significantly decreased. Consistently, starved mice, mRNA decreased intestine colon. Spexin injection increased velocity carbon powder propulsion small glass beads expulsion time distal colon mice. Further,...
Abstract Early childhood is a critical period for development, and early life stress may increase the risk of gastrointestinal diseases including irritable bowel syndrome (IBS). In rodents, neonatal maternal separation (NMS) induces dysfunctions that resemble IBS. However, underlying mechanisms remain unclear. Here we show NMS expansion intestinal stem cells (ISCs) their differentiation toward secretory lineages enterochromaffin (EC) Paneth cells, leading to EC hyperplasia, increased...
Hyperlipidemia and hepatic steatosis afflict over 75% of patients with type 2 diabetes, causing diabetic dyslipidemia. Cyclocarya paliurus (CP) leaf is a herbal tea which has long been consumed by the Chinese population, particularly people suffering from obesity diabetes. CP appears to exhibit hypolipidemic effect in lipid loaded mice (Kurihara et al., 2003), although detailed mechanisms active ingredients for this have not yet answered. In study, we investigated beneficial effects...
Demand forecasting is important for management and decision making in the tourism sector. However, research on deep learning forecasting, which combines multiple data sources, still development phase. This study proposes a bidirectional long short-term memory (BiLSTM) method incorporating an attention mechanism (ATT-BiLSTM) that can better extract features from set of predictor variables consisting (generated historical tourist volume, search engine data, weather day off data). The...
Foam has been successfully used to improve mobility control in the process of enhanced oil recovery, yet instability foam limits its application. Modified nanoparticles with varying wettability were prepared by reacting 3-methacryloxypropyltrimethoxysilane (KH570) spherical SiO 2 this study. Fourier transform infrared (FTIR) spectra and measured contact angles characterize surface properties modified particles, stabilization effects compared. Pore-scale visualization experiments conducted...
Hepatic stellate cells (HSCs) transdifferentiate into myofibroblasts during liver fibrosis and exhibit increased glycolysis. Phosphorylated focal adhesion kinase (FAK) (pY397-FAK) promotes monocarboxylate transporter 1 (MCT-1) expression in HSCs to increase aerobic glycolysis cause fibrosis. A combined multiomics analysis of C57BL/6 mice with tetrachloromethane (CCl4)-induced was performed identify the downstream FAK signaling pathway. The effect inhibitor PF562271 on CCl4-induced explored...
A hydro-mechanic model was put forward to study the fundamental nature of acupuncture meridians. The basic state low hydraulic resistance tested on humans and mini pigs using three methods. first, a modified Guyton's method, proved that there lower meridians compared with nonmeridians. second scanning method involved single pressure transducer can find lowest point in tissue, third used two transducers provided more stable measurement. Using latter points were found very close impedance...
Abstract Micellar fluids with viscoelastic behavior, or surfactant fluids, are used in the oil industry as completion and stimulation fluids. The (i.e. viscous elastic) behavior of these is based on overlap entanglement very long worm-like-micelles. High fluid leak-off has, however, limited their application for hydraulic fracturing frac-packing applications. Recent developments have found that micellar can wall-building control similar to crosslinked-polymer (CPF) by addition a small amount...
Spexin is a novel hormone involved in obesity and diabetes while its biofunctional significance lipid metabolism still to be comprehended. Global metabolomic analysis the present study revealed multiple metabolic pathways altered by spexin intraperitoneal (i.p.) injection rat serum, which are highlighted changes several bile acid metabolites. In rats, (300 μg/kg) could dramatically reduce hepatic circulating total acids (TBA) level compared with controls. Correspondingly, treatment i.p. for...
Spexin is a newly identified neuropeptide that involved in satiety control, glucose, and lipids metabolism. It has also been related to human diseases, such as obesity type 2 diabetes. However, whether spexin changes with age or not still unclear. The aim of this study investigate the relationship between circulating levels their interaction effects on body mass index (BMI), fasting -lipids. This cross-sectional study, including 68 healthy adult women whose ages are wide range (minimum: 23;...
MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still largely unknown. We systematically analyzed bioactive compounds mechanism-of-action biological targets through novel approach called "focused network pharmacology." Among 97 identified...