A5101836793- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Ubiquitin and proteasome pathways
- Epilepsy research and treatment
- Ion channel regulation and function
- Genomics, phytochemicals, and oxidative stress
- Free Radicals and Antioxidants
- Peroxisome Proliferator-Activated Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Human Pose and Action Recognition
- Pain Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Anesthesia and Sedative Agents
- Photoreceptor and optogenetics research
- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects of Natural Compounds
- Lipid metabolism and biosynthesis
- Neural dynamics and brain function
- Mitochondrial Function and Pathology
- EEG and Brain-Computer Interfaces
- Liver physiology and pathology
- Microbial Natural Products and Biosynthesis
Affiliated Hospital of Guizhou Medical University
2024-2025
Donghua University
2024-2025
Nanjing University of Science and Technology
2025
Guiyang Medical University
2024-2025
Chinese PLA General Hospital
2025
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Tianjin University of Technology
2024
Shanghai Pulmonary Hospital
2024
Tongji University
2024
Abstract Ubiquitin-specific protease 14 (USP14) is one of the major proteasome-associated deubiquitinating enzymes critical for proteome homeostasis. However, substrates USP14 remain largely unknown, hindering understanding its functional roles. Here we conduct a comprehensive proteome, ubiquitinome and interactome analysis substrate screening. Bioinformatics reveals broad new potential roles USP14, especially in lipid carbohydrate metabolism. Among identified, show that fatty acid synthase...
Flos Chrysanthemi Indici (FCI) is a Chinese herbal medicine used in China for over 2000 years. In this study, its ethanol extract (EFCL) was found to protect against hydroxyl radical (OH) induced oxidative damages mesenchymal stem cells (MSCs) and DNA. To explore the mechanism, EFCL further determined by chemical antioxidant assays. Folin–Ciocalteu colorimetric assay suggested that content of total phenolics 93.85 ± 3.56 mg catechin/g HPLC analysis indicated 10.05 1.44 mg/g as chlorogenic...
Children with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane, a commonly used anesthetic in children, has been reported decrease levels postsynaptic density 95 protein. However, the upstream mechanisms downstream consequences sevoflurane-induced reduction protein remains largely unknown. We therefore set out assess whether sevoflurane acts on ubiquitination-proteasome pathway facilitate degradation.Six-day-old wild-type...
In the context of advancing modern highway transportation and automotive industry, license plate recognition technology has become crucial for fulfilling demands traffic safety management within intelligent systems. This article aims to use convolutional neural networks accelerate car plates. Firstly, collected images are preprocessed by filtering denoising. Secondly, perform morphological operations on image, correction, contour detection determine position plate. Then adopt appropriate...
Hepatic stellate cells (HSCs) transdifferentiate into myofibroblasts during liver fibrosis and exhibit increased glycolysis. Phosphorylated focal adhesion kinase (FAK) (pY397-FAK) promotes monocarboxylate transporter 1 (MCT-1) expression in HSCs to increase aerobic glycolysis cause fibrosis. A combined multiomics analysis of C57BL/6 mice with tetrachloromethane (CCl4)-induced was performed identify the downstream FAK signaling pathway. The effect inhibitor PF562271 on CCl4-induced explored...
Abstract Chicoric acid is polyphenol of natural plant and has a variety bioactivity. Caused by various kinds stimulating factors, acute liver injury high fatality rate. The effect chicoric in induced Lipopolysaccharide (LPS) d ‐galactosamine ( ‐GalN) was investigated this study. results showed that CA decreased the aspartate aminotransferase (AST) alanine (ALT) serum reduced mortality LPS/ ‐GalN. can restrain mitogen‐activated protein kinases (MAPKs) nuclear factor‐kappa B (NF‐κB) to...
Background and Purpose — The function-related group (FRG) classification is based on functional assessment has been assumed to encompass the effects of different patterns severity neurological impairments. This assumption may not be correct. It proposed as a means comparing rehabilitation outcome across institutions. If impairments significantly affect FRG outcome, then higher scores reflect selection bias favoring patients with fewer rather than better quality care. goal this study was...
The interfacial tension of rhamnolipids and their applications in enhanced oil recovery are dependent on chemical structures compositions. To improve performances recovery, the engineered strategies were applied to produce novel with different compositions.By introducing key genes for rhamnolipid biosynthesis, Escherichia coli was firstly constructed that showed from those Pseudomonas aeruginosa due fatty acyl Then, mutant RhlBs created by directed evolution subsequent site-directed...
[6]-Gingerol is known as the major bioactive constituent of ginger. In study, it was observed to effectively protect against <TEX>${\bullet}OH$</TEX>-induced DNA damage (<TEX>$IC_{50}$</TEX> <TEX>$328.60{\pm}24.41{\mu}M$</TEX>). Antioxidant assays indicated that [6]-gingerol could efficiently scavenge various free radicals, including <TEX>${\bullet}OH$</TEX> radical <TEX>$70.39{\pm}1.23{\mu}M$</TEX>), <TEX>${\bullet}O_2{^-}$</TEX> <TEX>$228.40{\pm}9.20{\mu}M$</TEX>),...
Insulin resistance is a critical factor in the development of metabolic disorders, including type 2 diabetes (T2DM). However, its molecular mechanisms remain incompletely understood. In this study, we found that F-box only protein (FBXO2), substrate recognition component Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complex, was upregulated livers obese mice. Furthermore, using purification approach combined with high-performance liquid chromatography/tandem mass spectrometry, carried out...
As a phenolic alkaloid occurring in Cruciferous plants, sinapine was observed to protect mesenchymal stem cells (MSCs) against ·OH-induced damage this study. It also found prevent DNA from damage, scavenge various free radicals (·OH, ·O2−, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid diammonium salt) (ABTS)+·, and 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·)), reduce Cu2+ Cu+. To further explore the mechanism, end-product of reaction with DPPH· determined using HPLC-electrospray...
Magnolol (MG) is a kind of lignin isolated from Magnolia officinalis, which serves several different biological functions, such as antifungal, anticancer, antioxidant and hepatoprotective functions. This study aimed to evaluate the protective effect MG against oleic acid (OA)-induced hepatic steatosis inflammatory damage in HepG2 cells tyloxapol-induced hyperlipidemia mouse model. Our findings indicated that can effectively inhibit OA-stimulated tumor necrosis factor α (TNF-α) secretion,...