A5078438713- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Water Quality and Pollution Assessment
- Antimicrobial Peptides and Activities
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Kruppel-like factors research
- Aerodynamics and Fluid Dynamics Research
- Medicinal Plants and Bioactive Compounds
- Mine drainage and remediation techniques
- Environmental Quality and Pollution
- Immune cells in cancer
- Andrographolide Research and Applications
- Ginger and Zingiberaceae research
- Sesquiterpenes and Asteraceae Studies
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Noise Effects and Management
- Pharmacological Effects of Natural Compounds
- Wind and Air Flow Studies
Jilin University
2017-2024
Jilin Medical University
2023
Shenyang Jianzhu University
2020
Abstract Non‐alcohol fatty liver disease (NAFLD) is a common which causes serious damage. Geniposide (GEN), kind of iridoid glycoside extracted from Gardenia jasminoides fruit , has many biological effects, such as resistance to cell damage and anti‐neurodegenerative disorder. Lipid accumulation was obvious in tyloxapol‐induced oil acid (OA) with palmitic (PA)‐induced HepG2 cells compared the control groups while GEN improved increasing conditions. significantly lessened total cholesterol...
Abstract Chicoric acid is polyphenol of natural plant and has a variety bioactivity. Caused by various kinds stimulating factors, acute liver injury high fatality rate. The effect chicoric in induced Lipopolysaccharide (LPS) d ‐galactosamine ( ‐GalN) was investigated this study. results showed that CA decreased the aspartate aminotransferase (AST) alanine (ALT) serum reduced mortality LPS/ ‐GalN. can restrain mitogen‐activated protein kinases (MAPKs) nuclear factor‐kappa B (NF‐κB) to...
Nonalcoholic fatty liver disease (NAFLD) is a kind of serious fat disorder that has become critical problem to human society. Therefore, finding drugs are safe and effective more important. Erythritol (Ery) polyol sweetener with variety biological functions. However, whether Ery relieving effect on NAFLD not been reported yet. we induced HepG2 cells oleic acid palmitic as our in vitro model. Moreover, choose wild-type mice tyloxapol high-fat diet nuclear factor E2-related 2 (Nrf2) knockout...
Glycyrrhiza glabra L. is a common heritage herbal medicine rich in antioxidant compounds such as flavonoids and triterpenoids. Non-alcoholic fatty liver disease has been the global prevalent chronic disorder. To investigate curative role mechanism of crude extract on NAFLD, vitro, we used oleic acid, palmitic ML-385 3-MA to stimulate HepG2 cells. In vivo, Tyloxapol inject mice intraperitoneally establish an acute model, high-fat diet feed wild-type, Nrf2-/- ATG5flox/flox model. We high...
Overdose of acetaminophen (APAP) is currently one the main causes hepatoxicity and acute liver injury, which often linked to oxidative stress. Phellinus linteus polysaccharides (Phps) have shown many hepatoprotective effects, however, mechanism Phps on APAP-induced injury has not been further elucidated. The aim this study investigate underlying injury. expression AMPK/Nrf2 autophagy were detected using western blot. results indicated that treatment effectively alleviated by reducing alanine...
The occurrence of atherosclerosis is closely related to inflammation and lipid metabolism disorder. It has been found that lipopolysaccharide (LPS) could induce inflammation, tyloxapol (Ty) hyperlipidemia. However, the effects LPS Ty on development mechanism have not investigated thoroughly. To answer this question, we used assay kits detect total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) content evaluate dyslipidemia. We hematoxylin eosin staining pathological...
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is a common cause of injury and increases the risk for other diseases, particularly with rising rates obesity. Picroside has been utilized as traditional Chinese medicine protection thousands years, II known its anti-inflammatory anti-oxidation effects. Methods We used C57BL/6 mice to establish tyloxapol-induced NAFLD model employed oleic acid (OA) palmitic (PA) cell model. Fat concentration activation AMPK-Nrf2 pathway were...