A5048903557- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Diet, Metabolism, and Disease
- Reproductive Physiology in Livestock
- Drug-Induced Hepatotoxicity and Protection
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and disorders
- Ruminant Nutrition and Digestive Physiology
- Ginger and Zingiberaceae research
- Immune Response and Inflammation
- Medicinal Plants and Bioactive Compounds
- Autophagy in Disease and Therapy
- Phytochemistry and Biological Activities
- NF-κB Signaling Pathways
- Infant Health and Development
- Flavonoids in Medical Research
- Effects of Environmental Stressors on Livestock
- Phytochemical and Pharmacological Studies
- Animal health and immunology
- Chemotherapy-induced organ toxicity mitigation
- Plant Disease Management Techniques
- Bone Metabolism and Diseases
Northwest A&F University
2021-2024
Jilin University
2014-2024
Xi'an Jiaotong University
2023
Jilin Medical University
2017-2023
Agriculture and Forestry University
2023
Abstract Aucubin ( AU ) is the main active ingredient of Aucuba japonica which has showed many positive effects such as anti‐inflammation and liver protection. Non‐alcoholic fatty disease NAFLD most common cause chronic disease. In this research, we explored on tyloxapol‐induced in mice apolipoprotein C‐ III (apoC‐ induced‐3T3L1 cells. Tyloxapol (300 mg/kg) was injected to C57 BL /6 with aucubin. The differentiated 3T3‐L1 cells were treated or without aucubin after stimulation apoC‐ (100...
Abstract Non‐alcohol fatty liver disease (NAFLD) is a common which causes serious damage. Geniposide (GEN), kind of iridoid glycoside extracted from Gardenia jasminoides fruit , has many biological effects, such as resistance to cell damage and anti‐neurodegenerative disorder. Lipid accumulation was obvious in tyloxapol‐induced oil acid (OA) with palmitic (PA)‐induced HepG2 cells compared the control groups while GEN improved increasing conditions. significantly lessened total cholesterol...
The activation of nuclear factor erythroid 2-related 2 (Nrf2) is closely related to the alleviation nonalcoholic fatty liver disease (NAFLD) by regulating oxidative stress and lipid homeostasis. Gentiopicroside (GPS), an iridoid glycoside found in Gentianaceae, possesses anti-inflammatory antioxidant effects. However, protective effects GPS on accumulation damage have not been investigated thoroughly free acid- (FFA-) induced HepG2 cells tyloxapol- (Ty-) hyperlipidemia mice. Cell counting...
Baicalin is an active ingredient extracted from the Chinese medicine Scutellaria and has many beneficial effects. Pulmonary interstitial alveolar edema are common symptoms of acute lung injury (ALI). We investigated effects baicalin on LPS-induced inflammation underlying mechanisms in mice cells. The protein contents mRNA expression TNF-α, IL-1β, IL-6 RAW264.7 cells were detected using ELISA qRT-PCR. significantly suppressed levels expression, both vitro vivo, compared with LPS group....
Ketosis, a commonly observed energy metabolism disorder in dairy cows during the peripartal period, is distinguished by increased concentrations of β-hydroxybutyrate (BHB) blood. This condition has negative impact on milk production and quality, causing financial losses. An untargeted metabolomics approach was performed plasma samples from between 5 7 DIM diagnosed as controls (CON, BHB <1.2 mM, n = 30), subclinically ketotic (SCK, 1.2 < <3.0 or clinically (CK, >3.0 30). Cows were selected...
Abstract Chicoric acid is polyphenol of natural plant and has a variety bioactivity. Caused by various kinds stimulating factors, acute liver injury high fatality rate. The effect chicoric in induced Lipopolysaccharide (LPS) d ‐galactosamine ( ‐GalN) was investigated this study. results showed that CA decreased the aspartate aminotransferase (AST) alanine (ALT) serum reduced mortality LPS/ ‐GalN. can restrain mitogen‐activated protein kinases (MAPKs) nuclear factor‐kappa B (NF‐κB) to...
PANoptosis is an intricate programmed death pathway that involves the interaction between pyroptosis, apoptosis, and necroptosis. We systematically explored protective effect of Echinacea polyphenols (EPP) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) underlying mechanisms both in vitro vivo. noted EPP pretreatment could significantly alleviate LPS-induced tissue pulmonary edema. inhibited by regulating expression nucleotide-binding oligomerization domain-like receptor...
Magnolol (MG) is a kind of lignin isolated from Magnolia officinalis, which serves several different biological functions, such as antifungal, anticancer, antioxidant and hepatoprotective functions. This study aimed to evaluate the protective effect MG against oleic acid (OA)-induced hepatic steatosis inflammatory damage in HepG2 cells tyloxapol-induced hyperlipidemia mouse model. Our findings indicated that can effectively inhibit OA-stimulated tumor necrosis factor α (TNF-α) secretion,...
Subacute ruminal acidosis (SARA) can increase the level of inflammation and induce rumenitis in dairy cows. Berberine (BBR) is major active component Rhizoma Coptidis, which a type Chinese anti-inflammatory drug for gastrointestinal diseases. The purpose this study was to investigate effects BBR on lipopolysaccharide (LPS)-stimulated rumen epithelial cells (REC) underlying molecular mechanisms. REC were cultured stimulated with LPS presence or absence different concentrations BBR. results...
Chromium propionate (Cr-Pro) and calcium (Ca-Pro) are widely applied in dairy production, especially the alleviation of heat stress (HS). HS can reduce abundance rumen microbiota lactation performance cows. The present work mainly focused on evaluating effects Cr-Pro Ca-Pro performance, ruminal bacterial community, postpartum cows as well identifying differences their mechanisms. Fifteen multiparous Holstein with equivalent weights (694 ± 28 kg) milk yields (41.2 1.21 kg/day) were randomly...
Shikonin (SHK) has various biological and pharmacological activities, including anticancer, antibacterial anti-inflammation activities.
Abstract Morin (MO), a natural bioflavinoid, exists in many herbs. Previous studies have acclaimed MO's anti‐inflammatory, antidiabetic, antioxidant, antifibrotic, anticancer, and antihyperglycemic biological effects. This study aimed to assess the molecular mechanism of MO involved oleic acid (OA)‐induced inflammatory damage lipid accumulation HepG2 cell tyloxapol (Ty)‐induced hyperlipidemia mice. We found that can efficaciously mitigate reactive tumor necrosis factor‐α (TNF‐α) level...
Subclinical hyperketonemia (SCHK) is the major metabolic disease observed during transition period in dairy goats, and characterized by high plasma levels of nonesterified fatty acids (NEFA) β-hydroxybutyrate (BHB). However, no prior study has comprehensively assessed metabolomic profiles goats with SCHK. Plasma samples were collected within 1 h after kidding from SCHK (BHB concentration >0.8 mM, n = 7) clinically healthy <0.8 similar body condition score (2.75 ± 0.15, mean standard error...
The present study evaluated the effects of strontium (Sr) on proliferation and differentiation chondrocytes isolated from dairy cows, whether Sr exerts its via transforming growth factor β (TGFβ) signaling. were patellar cartilage newborn Holstein bull calves ( n = 3, 1 day old, 38.0 ± 2.8 kg, fasting) within 15 min after euthanasia, treated with different concentrations (0, 0.1, 1, 10 μg/ml, as SrCl 2 ·6H O). After pretreatment or without activin receptor-like kinase 5 (ALK5) inhibitor (10...
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is a common cause of injury and increases the risk for other diseases, particularly with rising rates obesity. Picroside has been utilized as traditional Chinese medicine protection thousands years, II known its anti-inflammatory anti-oxidation effects. Methods We used C57BL/6 mice to establish tyloxapol-induced NAFLD model employed oleic acid (OA) palmitic (PA) cell model. Fat concentration activation AMPK-Nrf2 pathway were...