A5100733463- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Plant Toxicity and Pharmacological Properties
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Biological and pharmacological studies of plants
- Metabolomics and Mass Spectrometry Studies
- Wood and Agarwood Research
- Chromatography in Natural Products
- Microbial Metabolism and Applications
- Methane Hydrates and Related Phenomena
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Cancer-related molecular mechanisms research
- Analytical Chemistry and Chromatography
- MicroRNA in disease regulation
- Plant-based Medicinal Research
- Cultural Heritage Materials Analysis
- Autophagy in Disease and Therapy
- Food Quality and Safety Studies
- Diet and metabolism studies
Shanghai University of Traditional Chinese Medicine
2016-2025
State Administration of Traditional Chinese Medicine of the People's Republic of China
2016-2025
Chinese Academy of Tropical Agricultural Sciences
2018-2025
China Medical University
2018-2025
Gannan Normal University
2025
Jiangxi Agricultural University
2025
Sinopec (China)
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Guangdong Work Injury Rehabilitation Hospital
2025
Jinan University
2015-2025
Epigenetic reprogramming of myeloid cells, also known as trained immunity, confers nonspecific protection from secondary infections. Using histone modification profiles human monocytes with the Candida albicans cell wall constituent β-glucan, together a genome-wide transcriptome, we identified induced expression genes involved in glucose metabolism. Trained display high consumption, lactate production, and ratio nicotinamide adenine dinucleotide (NAD(+)) to its reduced form (NADH),...
Abstract Background Although gemcitabine-based chemotherapy has been established as a core multimodal therapy for non-small cell lung cancer (NSCLC) treatment, its clinical efficacy remains limited by the development of acquired resistance following tumor metastasis and relapse. In this study, we investigated how gemcitabine-resistant (GR) cells contribute to NSCLC malignancy via exosome-mediated transfer microRNAs. Methods We first studied mechanism exosome internalization PKH-67 staining...
Abstract: Autophagy dysfunction is considered as a potential toxic mechanism of nanomaterials. Silica nanoparticles (SiNPs) can induce autophagy, but the specific involved remains unclear. Therefore, aim this study was to confirm effects SiNPs on autophagy and explore possible underlying mechanism. In article, we reported that cell-internalized exhibited dose- time-dependent cytotoxicity in both L-02 HepG2 cells. Multiple methods verified induced even at noncytotoxic level blocked autophagic...
Rosacea is an inflammatory skin disorder characterized by the release of mediators from keratinocytes, which are thought to play a crucial role in its pathogenesis. Despite incidence approximately 5.5%, rosacea associated with poor quality life. However, as pathogenesis remains enigmatic, treatment options limited. To investigate and explore new therapeutic strategies. Transcriptome data patients combined immunohistochemical staining were used activation STAT3 rosacea. The was subsequently...
The field of infected wound management continues to face challenges, and traditional methods used cope with wounds include debridement, gauze coverage, medication, others. Currently, synthetic natural biomaterials are readily available today, enabling the creation new dressings that substantially enhance healing. Considerable attention is being paid hydrogels based on materials, which have good biocompatibility degradability properties, while exhibiting higher similarity extracellular matrix...
Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries used for remission obesity and diabetes. However, precise molecular mechanism by which VSG exerts its beneficial effects remains elusive. We report that membrane‐bound G protein‐coupled bile acid receptor, GPBAR‐1 (also known as TGR5), required to mediate anti‐obesity, anti‐hyperglycemia, improvements fatty liver in mice. In absence TGR5, metabolic mice are lost. Moreover, we found expression...
Small interfering RNAs (siRNA)/microRNAs (miRNA) have promising therapeutic potential, yet their clinical application has been hampered by the lack of appropriate delivery systems.Herein, we employed extracellular vesicles (EVs) as a targeted system for small RNAs.EVs are cell-derived that participate in cell-to-cell communication protein and RNA delivery.We used aptamer AS1411-modified EVs siRNA/microRNA to breast cancer tissues.Tumor targeting was facilitated via AS1411 binding nucleolin,...
Herein, we report a class of molecular spherical nucleic acid (SNA) nanostructures. These nano-sized single molecules are synthesized from T8 polyoctahedral silsesquioxane and buckminsterfullerene C60 scaffolds, modified with 8 12 pendant DNA strands, respectively. conjugates have different surface densities thus exhibit levels nuclease resistance, cellular uptake, gene regulation capabilities; the properties displayed by SNA conjugate closer to those conventional prototypical gold...
Abstract The fucosyltransferase (FUT) family produces glycans, a fundamental event in several cancers, including colorectal cancer (CRC). miR-125a-3p is non-coding RNA that can reduce cell proliferation and migration cancer. In this study, we explored the levels of FUT expression human CRC tissues two lines by qPCR. results showed miR-125a-3p, FUT5 FUT6 are differentially expressed normal tumour tissues. On basis our previous research, be regulated miRNA, which influences invasion breast...