A5059940437- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Circular RNAs in diseases
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Environmental Toxicology and Ecotoxicology
- Fish Ecology and Management Studies
- Extracellular vesicles in disease
- Mercury impact and mitigation studies
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Garlic and Onion Studies
- Gastroesophageal reflux and treatments
- Veterinary medicine and infectious diseases
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Galectins and Cancer Biology
Wenzhou Medical University
2019-2025
Huazhong University of Science and Technology
2025
Institute of Oceanology
2020-2024
Nanjing Drum Tower Hospital
2024
Yanbian University
2024
University of Electronic Science and Technology of China
2024
Quzhou University
2024
Affiliated Hospital of North Sichuan Medical College
2015-2024
Hangzhou Cancer Hospital
2021-2024
University of Macau
2024
Gastrointestinal microbiota may be involved in Helicobacter pylori-associated gastric cancer development. The aim of this study was to explore the possible microbial mechanisms carcinogenesis and potential dysbiosis arising from H. pylori infection.Deep sequencing 16S ribosomal RNA gene used investigate alterations paired biopsies stool samples 58 subjects with successful 57 failed anti-H. treatment, relative 49 negative subjects.In positive subjects, richness Shannon indexes increased...
Abstract Background Although gemcitabine-based chemotherapy has been established as a core multimodal therapy for non-small cell lung cancer (NSCLC) treatment, its clinical efficacy remains limited by the development of acquired resistance following tumor metastasis and relapse. In this study, we investigated how gemcitabine-resistant (GR) cells contribute to NSCLC malignancy via exosome-mediated transfer microRNAs. Methods We first studied mechanism exosome internalization PKH-67 staining...
To assess the effects of Helicobacter pylori treatment, vitamin supplementation, and garlic supplementation in prevention gastric cancer.Blinded randomized placebo controlled trial.Linqu County, Shandong province, China.3365 residents a high risk region for cancer. 2258 participants seropositive antibodies to H were randomly assigned or their placebos 2×2×2 factorial design, 1107 seronegative 2×2 design.H treatment with amoxicillin omeprazole two weeks; (C, E, selenium) (extract oil) 7.3...
The CHOICE-01 study investigated the efficacy and safety of toripalimab in combination with chemotherapy as a first-line treatment for advanced non-small-cell lung cancer (NSCLC).Patients (N = 465) treatment-naive, NSCLC without EGFR/ALK mutations were randomly assigned 2:1 to receive 240 mg (n 309) or placebo 156) once every 3 weeks 4-6 cycles, followed by maintenance plus standard care. Stratification factors included programmed death ligand-1 expression status, histology, smoking status....
Abstract Estrogen receptor positive (ER+) breast cancer accounts for approximately 70% of cases. Endocrine therapies targeting estrogen are the first line ER+ cancer. However, resistance to these occurs in about half patients, leading decreased survival rates. Inducing ferroptosis is a promising therapeutic strategy treatment refractory and malignant cancers including triple-negative Nevertheless, relatively resistant inducers. Here, we uncovered that ERα suppressed Silencing triggered...
<h3>Objective</h3> To clarify the full range of benefits and adverse consequences <i>Helicobacter pylori</i> eradication as a strategy for gastric cancer prevention, community-based intervention trial was launched in Linqu County, China. <h3>Design</h3> A total 184 786 residents aged 25–54 years were enrolled this received <sup>13</sup>C-urea breath test. <i>H. positive participants assigned into two groups, either receiving 10-day quadruple anti-<i>H. treatment or lookalike placebos...
Human microRNA-155 (miR-155) has been demonstrated to regulate a variety of cellular functions, including epithelial-to-mesenchymal transition (EMT) by targeting multiple messenger RNAs (mRNAs). However, its role in colorectal cancer (CRC) remains unelucidated. Therefore, the aim present study was investigate effects miR-155 on CRC cells. The expression level quantified quantitative real-time reverse transcriptase-PCR (qRT-PCR) primary tissues and normal adjacent mucosa. MTT, migration...
Abstract Background MicroRNAs(miRNAs) are small non-coding RNAs that participate in a variety of biologic processes, and dysregulation miRNA is always associated with cancer development progression. Aberrant expression miR-378 has been found some types cancer. However, effects potential mechanisms colorectal (CRC) have not explored. Methods Quantitative RT-PCR was performed to evaluate levels CRC cell lines 84 pairs normal adjacent mucosa. Kaplan–Meier Cox proportional regression analyses...
Type 2 Diabetes Mellitus (T2DM) is characterized by insulin resistance (IR), but the underlying molecular mechanisms are incompletely understood. MicroRNAs (miRNAs) have been demonstrated to participate in signalling pathways relevant glucose metabolism IR. The purpose of this study was test whether multiple-target anti-miRNA antisense oligonucleotides (MTg-AMO) technology, an innovative miRNA knockdown strategy, can be used interfere with multiple miRNAs that play critical roles regulating...
<h3>Importance</h3> Metabolic deregulation plays an important role in gastric cancer (GC) development. To date, no studies have comprehensively explored the metabolomic profiles along cascade of lesions toward GC. <h3>Objective</h3> draw a metabolic landscape and define signatures associated with progression risk early <h3>Design, Setting, Participants</h3> A 2-stage, population-based cohort study was initiated 2017 Linqu County, Shandong Province, China, high-risk area for Prospective...
Growing evidence suggests that microRNAs (miRNAs) play an important role in tumor development, progression and metastasis. Aberrant miR-106b expression has been reported several cancers. However, the underlying mechanism of miR-106 colorectal cancer (CRC) have not addressed.Quantitative RT-PCR(qRT-PCR) was performed to evaluate levels CRC cell lines patient specimens. Cell proliferation detected using MTT assay, migration invasion ability were evaluated by wound healing assay transwell...
An increase in cytosolic free Ca(2+) concentration ([Ca(2+)]cyt) pulmonary arterial smooth muscle cells (PASMC) is a major trigger for vasoconstriction and critical stimulation PASMC proliferation migration. Previously, we demonstrated that expression function of calcium sensing receptors (CaSR) from patients with idiopathic hypertension (IPAH) animals experimental (PH) were greater than normal subjects control animals. However, the mechanisms by which CaSR triggers influx implication...
Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells Sunkui Ke,1 Tong Zhou,2 Peiyan Yang,3 Yange Wang,2 Peng Zhang,2 Keman Chen,2 Lei Ren,2 Shefang Ye2 1Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, 2Department Biomaterials, College Materials, 3Department First Affiliated Xiamen, People’s Republic China Abstract: Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)...
Abstract: Polyhydroxylated derivatives of fullerene C 60 , named fullerenols (C [OH] n ), have stimulated great interest because their potent antioxidant properties in various chemical and biological systems, which enable them to be used as a new promising pharmaceutical for the future treatment oxidative stress-related diseases, but details remain unknown. Nuclear factor erythroid 2-related 2 (Nrf2) is principal transcription that regulates expression several genes via binding response...
Abstract Background: Genetic polymorphisms of Toll-like receptors (TLR) may influence the outcome Helicobacter pylori infection and play important roles in gastric carcinogenesis. To screen genetic variants TLR2 TLR5, evaluate their associations with cancer (GC) its precursors, a population-based study was conducted Linqu County, Shandong Province, China. Methods: were identified by PCR-based denaturing high-performance liquid chromatography PCR-restriction fragment length polymorphism...