A5087251992- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Carbon and Quantum Dots Applications
- Colorectal Cancer Treatments and Studies
- Nanocluster Synthesis and Applications
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
Jiangsu Province Hospital
2014-2025
Nanjing Medical University
2015-2025
Zhuhai People's Hospital
2020-2025
Jinan University
2020-2025
ShanghaiTech University
2023-2025
Peking Union Medical College Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Chinese Academy of Sciences
2013-2024
First Affiliated Hospital of Zhengzhou University
2021-2024
Nanjing Normal University
2024
IntroductionSintilimab, an anti–programmed death 1 antibody, plus pemetrexed and platinum had revealed promising efficacy for nonsquamous NSCLC in a phase 1b study. We conducted randomized, double-blind, 3 study to compare the safety of sintilimab with placebo, both combination such chemotherapy (ClinicalTrials.gov: NCT03607539).MethodsA total 397 patients previously untreated, locally advanced or metastatic without sensitizing EGFR anaplastic lymphoma kinase genomic aberration were...
H19 RNA has been characterized as an oncogenic long non-coding (lncRNA) in breast and colon cancer. However, the role function of lncRNA glioma development remain unclear. In this study, we identified that H19/miR-675 signaling was critical for progression. By analyzing gene expression data sets, found increased high grade gliomas. depletion via siRNA inhibited invasion cells. Further, positively correlated with its derivate miR-675 reduction expression. Bioinformatics luciferase reporter...
Long noncoding RNA Hox transcript antisense intergenic (HOTAIR) has been characterized as a negative prognostic factor in breast and colon cancer patients. The clinical significance function of HOTAIR glioma remains unclear.We analyzed the 3 different cohorts with gene expression data, including correlation tumor grade, prognosis, molecular subtype. was explored by performing set enrichment analysis vitro vivo experiments.HOTAIR closely associated grade poor prognosis. Multivariate Cox...
Postmeiotic spermatids use a unique strategy to coordinate gene expression with morphological transformation, in which transcription and translation take place at separate developmental stages, but how mRNAs stored as translationally inert messenger ribonucleoproteins developing become activated remains largely unknown. Here, we report that the RNA binding protein FXR1, member of fragile X-related (FXR) family, is highly expressed late undergoes liquid-liquid phase separation (LLPS) merge...
The CHOICE-01 study investigated the efficacy and safety of toripalimab in combination with chemotherapy as a first-line treatment for advanced non-small-cell lung cancer (NSCLC).Patients (N = 465) treatment-naive, NSCLC without EGFR/ALK mutations were randomly assigned 2:1 to receive 240 mg (n 309) or placebo 156) once every 3 weeks 4-6 cycles, followed by maintenance plus standard care. Stratification factors included programmed death ligand-1 expression status, histology, smoking status....
MicroRNAs (miRNAs) are highly evolutionarily-conserved non-coding small RNAs, which were first identified in Caenorhabditis elegans. Let-7 miRNA is involved the regulation of gene expression cells. Several novel factors and feedback loops synthesis let-7 have been additional target genes found. has also shown to be significantly correlated with occurrence development cancer results preliminary studies suggest that it oncogenic pathways numerous types tumors. is, therefore, a potential...
MIR155 host gene (MIR155HG) is a long noncoding RNA that has been considered as the primary micro (mi)RNA of miR-155. MIR155HG plays an essential role in hematopoiesis, inflammation, and tumorigenesis. Our study investigated clinical significance, biological function, mechanisms, small-molecule inhibitors MIR155HG/miR-155 axis glioma. We analyzed expression correlation with glioma grade patient survival using 2 different datasets. Biological significance was elucidated through series vitro...
Although a number of methods to perform assays tetracyclines using fluorescent probes have been reported, approaches for discriminating and detecting are few.
Abstract Background MiR-221 and miR-222 (miR-221/222), upregulated in gliomas, can regulate glioma cell cycle progression apoptosis, respectively. However, the association of miR-221/222 with invasion survival remains unknown. Methods Invasion capability was detected by mutiple analyses, including diffusion tensor imaging (DTI), transwell, wound healing nude mouse tumor xenograft model assay. Further, target determined luciferase reporter, western blot gene rescue The outcome examined fifty...
// Wenkang Luan 1,* , Yingyi Wang Xincheng Chen Yan Shi Jiajia 1 Junxia Zhang Jin Qian 2 Ri Li Tao Wenjin Wei Qi Hu Ning Liu and Yongping You Department of Neurosurgery, The First Affiliated Hospital Nanjing Medical University, Nanjing, China People’s Xuancheng City, Anhui, * These authors contributed equally to this work Correspondence to: You, email: Keywords : let-7a microRNA, c-Myc, hnRNPA1, PKM2, glucose metabolism, aerobic glycolysis, glioma Received October 08, 2014 Accepted...
Abstract H19 expression is elevated in many human tumors including glioblastomas, suggesting an oncogenic role for the long noncoding RNA; yet upregulation of glioblastomas remains unclear. Here we report that hypoxia significantly stimulated glioblastoma cell lines, which was related to hypoxia-inducible factors 1α (Hif-1α). Hif-1α promoted U87 and U251 cells. Meanwhile PTEN advantageous factor affect expression, through attenuating stability. also positively correlates with samples...
BackgroundAn artificial intelligence method could accelerate the clinical implementation of tumour-stroma ratio (TSR), which has prognostic relevance in colorectal cancer (CRC). We, therefore, developed a deep learning model for fully automated TSR quantification on routine haematoxylin and eosin (HE) stained whole-slide images (WSI) further investigated its validity patient stratification.MethodsWe trained convolutional neural network (CNN) using transfer learning, with nine-class tissue...
Glioblastoma multiforme (GBM) is the most common and aggressive form of astrocytoma among adult brain tumors. Multiple studies have shown that long non-coding RNAs (lncRNAs) play important roles in acting as molecular sponge for competing with microRNAs (miRNAs) to regulate downstream molecules tumor progression. We previously reported miR155 host gene (miR155HG), an lncRNA, its derivative miR-155 promote epithelial-to-mesenchymal transition glioma. However, other biological functions...
Epithelial cell transformation sequence 2 (ECT2) is upregulated in glioma and promotes proliferation. A preliminary experiment showed a positive correlation between ECT2 pituitary tumor-transforming gene 1 (PTTG1). The aim of this study was to explore how affects PTTG1 influence the proliferation cells. expression detected by western blot reverse transcription PCR. effect on examined using proliferation–related assays vivo experiments. stability E2F factor (E2F1) were blot,...
Integrating kinds of bactericides as one entirety shows prospect for improving antibacterial efficiency, thus a new type nanoclusters based on bactericide-directed herein emerged combination achieving higher effect. Specifically, an easily operated approach preparing bacitracin-directed silver, gold, and copper (AgNCs, AuNCs, CuNCs, respectively) was proposed. Meanwhile, AgNCs@Bacitracin, AuNCs@Bacitracin, CuNCs@Bacitracin emitted cyan, yellow, red colors fluorescence, respectively,...
Abstract A tactile sensor system enables natural interaction between humans and machines; this is crucial for dexterous robotic hands, interactive entertainment, other smart scenarios. However, the lack of sliding friction detection significantly limits accuracy scope interactions due to absence sophisticated information, such as slippage, material roughness held objects. Here, inspired by stick-slip phenomena in process, we have developed a multifunctional biomimetic based on sensing...
A promising direction in the research on Alzheimer’s Disease (AD) is identification of biomarkers that better inform disease progression AD. However, performance amyloid-based predicting cognitive has been shown to be suboptimal. We hypothesise neuronal loss could impairment. have utilised 5xFAD transgenic mouse model displays AD pathology at an early phase, already fully manifested after 6 months. evaluated relationships between impairment, amyloid deposition, and hippocampus both male...
Enhancer of zeste homolog 2 (EZH2) is the catalytic unit polycomb repressive complex (PRC2) which epigenetically silences many genes involved in tumor-suppressive mechanisms via trimethylation lysine 27 histone H3 (H3K27me3). We recently found that overexpression EZH2 was associated with poor outcome glioblastoma (GBM). In this study, we examined antitumor effects inhibitor GSK343 on glioma cells vitro and vivo. The proliferation cell cycle measured. Wound healing assay transwell invasion...