A5101871197- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Receptor Mechanisms and Signaling
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Adrenal Hormones and Disorders
- Cardiac electrophysiology and arrhythmias
- Pregnancy and preeclampsia studies
- Protein Kinase Regulation and GTPase Signaling
- Salivary Gland Disorders and Functions
- Hydrocarbon exploration and reservoir analysis
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Quantum Dots Synthesis And Properties
- Clinical Laboratory Practices and Quality Control
- Neuroscience and Neuropharmacology Research
Westlake University
2024
Fudan University
2024
Beihang University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Peking Union Medical College Hospital
2017-2024
Zhujiang Hospital
2023-2024
Southern Medical University
2016-2024
Jinan University
2017-2024
Key Laboratory of Guangdong Province
2017-2024
Fujian Provincial Hospital
2008-2023
Abstract In the event of a public health crisis, highly effective and sustainable antimicrobial materials equipment will be urgently needed. Here, preparation is reported by electrospinning broad‐spectrum antibacterial nanofibers embedded in photoactive hydrogen‐bonded organic framework (HOF) rod‐like nanocrystals ≈60 nm length. The resulting HOF@PVDF‐HFP maintain excellent tensile breathability characteristics while shielding HOF against acid alkali corrosion. A series with different...
The metabolic checkpoint kinase mechanistic/mammalian target of rapamycin (mTOR) regulates natural killer (NK) cell development and function, but the exact underlying mechanisms remain unclear. Here, we show, via conditional deletion Raptor (mTORC1) or Rictor (mTORC2), that mTORC1 mTORC2 promote NK maturation in a cooperative non-redundant manner, mainly by controlling expression Tbx21 Eomes. Intriguingly, regulate cytolytic function an opposing way, exhibiting promoting inhibitory effects...
The immune response in cancer reflects a series of carefully regulated events; however, current tumor immunotherapies typically address single key aspect to enhance anti-tumor immunity. In the present study, nanoplatform (Fe3 O4 @IR820@CpG)-based immunotherapy strategy that targets multiple steps cancer-immunity cycle is developed: 1) promotes release tumor-derived proteins (TDPs), including tumor-associated antigens and pro-immunostimulatory factors), addition direct killing effect, by...
Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, but its clinical benefit is limited in advanced gastric (GC). Cancer-associated fibroblasts (CAFs) have been reported to be associated with ICB resistance, the underlying mechanism not fully elucidated. Our previous single-cell RNA-seq analysis of GC revealed that POSTN+FAP+ extracellular matrix CAFs (eCAFs) communicate macrophages. Here, we evaluated correlation between eCAFs and response TCGA-STAD real-world...
The habenula is a nuclear complex composed of the lateral (LHb) and medial (MHb), two distinct structures. Much progress has been made to emphasize role LHb in pathogenesis depression. In contrast, relatively less research focused on MHb. However, recent years, MHb begun gain increasing attention. connects interpeduncular nucleus (IPN) both morphologically functionally. MHb-IPN pathway plays an important regulating higher brain functions, including cognition, reward, decision making. It...
Twelve 1, 4-naphthoquinone derivatives, including two new (1 and 2) 10 known (3–12), were obtained from endophytic fungus Talaromyces sp. SK-S009 isolated the fruit of Kandelia obovata. All structures identified through extensive analysis nuclear magnetic resonance (NMR), mass spectrometry (MS) circular dichroism (CD), as well by comparison with literature data. These compounds significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine macrophage cell...
Background Programmed cell death protein-1/programmed ligand-1 (PD-1/PD-L1) inhibitors works by reactivating immune cells. Considering the accessibility of noninvasive liquid biopsies, it is advisable to employ peripheral blood lymphocyte subsets predict immunotherapy outcomes. Methods We retrospectively enrolled 87 patients with available baseline circulating subset data who received first-line PD-1/PD-L1 at Peking Union Medical College Hospital between May 2018 and April 2022. Immune...
Inhibition of phosphodiesterase 4 (PDE4) suppressed the inflammatory responses in brain. However, underlying mechanisms are poorly understood. Roflupram (ROF) is a novel PDE4 inhibitor. In present study, we found that ROF enhanced level microtubule-associated protein 1 light chain 3 II (LC3-II) and decreased p62 microglial BV-2 cells. Enhanced fluorescent signals were observed cells treated with by Lysotracker red acridine orange staining. addition, immunofluorescence indicated significant...
Analysis of circulating tumor cells (CTCs) is regarded as a useful diagnostic index to monitor development and guide precision medicine. Although the immunoassay common strategy for CTC identification heterogeneity characterization, it challenged by poor reaction efficiency laborious manipulations in microdevices, which hinder sensitivity, throughput, simplification, applicability. To meet need rapid, sensitive, simple analysis, we developed an efficient detection system integrating 3D...
UV exposure continues to induce many health issues, though commercial sunscreens are available. Novel filters with high safety and efficacy urgently needed. Metal-organic frameworks (MOFs) could be a suitable platform for filter development, due their tunable optical, electrical, photoelectric properties by precise controlled synthesis.Herein, four zinc-based MOFs various bandgap energies were chose investigate optical behaviors evaluate possibility as sunscreens. Zeolitic imidazolate...
Abstract The immunosuppressive tumor microenvironment (TME) severely limits the clinical applications of cancer immunotherapy. Herein, a hypoxia‐responsive delivery system is constructed simply by coordinating ferric (Fe 3+ ) with mitoxantrone (MTO), sulfasalazine (SAS), and hypoxia‐sensitive dopamine derivative polyethylene glycol (PEG) using “one‐pot” reaction for “closed‐loop” synergistic enhancement ferroptosis Hypoxia‐sensitive PEG ensures integrity in circulation to prevent premature...
There are no standard third-line treatment options for metastatic pancreatic ductal adenocarcinoma (mPDAC). Trametinib in combination with hydroxychloroquine (HCQ) or CDK4/6 inhibitors showed promising efficacy preclinical studies. However, the regimens have not been well examined patients mPDAC.Patients mPDAC who received of trametinib and HCQ as third- later-line therapy were reviewed. The prognosis further analyzed.A total 13 enrolled, whom 8 5 treated plus a inhibitor (palbociclib...
Abstract Introduction Two approaches were compared for the calculation of coefficient variation (CV) and bias, their effect on sigma calculation, when different allowable total error (TEa) values used to determine optimal method Six Sigma quality management in clinical laboratory. Materials methods metrics routine chemistry tests using three systems (Beckman AU5800, Roche C8000, Siemens Dimension) determined June 2017 laboratory Peking Union Medical College Hospital. Imprecision (CV%) bias...
Medullary thyroid carcinoma (MTC) patients with distant metastases frequently present a relatively poor survival prognosis. Our main purpose was developing nomogram model to predict in MTC patients.This retrospective study based on the Surveillance, Epidemiology, and End Results (SEER) database. Data of 807 diagnosed from 2004 2015 who undergone total thyroidectomy neck lymph nodes dissection included our study. Independent risk factors were screened by univariate multivariate logistic...
Critical limb ischemia (CLI) remains a significant clinical challenge with high morbidity and mortality. Considering the critical role of hypoxia-inducible factor 1α (HIF-1α) in hypoxic site to induce angiogenesis by regulating expression growth factors, we prepared cooperative composite (P-F-HKUST-1) mixing thermo-responsive hydrogel (PPCN) folic acid modified copper-based MOFs (F-HKUST-1) for hindlimb therapy. The gelation P-F-HKUST-1 muscle generated more serious environment subsequently...
Abstract Formamidinium lead iodide (FAPbI 3 ) perovskite has lately surfaced as the preferred contender for highly proficient and robust solar cells (PSCs), owing to its favorable bandgap superior thermal stability. Nevertheless, volatilization migration of ions (I − result in non‐radiating recombination centers, presence large formamidine (FA) cations tends cause lattice strain, thereby reducing power conversion efficiency (PCE) stability PSCs. To solve these problems, formate (PbFa) is...
DNA polymerase delta 1 catalytic subunit (POLD1) plays a key role in replication and damage repair. A defective proofreading function caused by POLD1 mutation contributes to carcinogenesis, while overexpression predicts poor prognosis cancers. However, the effect of hepatocellular carcinoma (HCC) is not well-understood.Expression patterns were evaluated TCGA HPA databases. Kaplan-Meier curves Cox regression used examine prognostic value POLD1. The predictive was further validated another...