A5024796706- Consumer Market Behavior and Pricing
- Microbial Natural Products and Biosynthesis
- Digital Platforms and Economics
- Marine Sponges and Natural Products
- Fungal Biology and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Muscle Physiology and Disorders
- Membrane Separation Technologies
- MicroRNA in disease regulation
- Botulinum Toxin and Related Neurological Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Spaceflight effects on biology
- Innovation Diffusion and Forecasting
- Trigeminal Neuralgia and Treatments
- Advanced Wireless Communication Techniques
- Technology Adoption and User Behaviour
- Digital Marketing and Social Media
- Membrane-based Ion Separation Techniques
- ICT Impact and Policies
- Facial Nerve Paralysis Treatment and Research
- Immunotherapy and Immune Responses
- Pharmaceutical industry and healthcare
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
Songshan Lake Materials Laboratory
2025
Guangdong Medical College
2012-2025
Peking University
2011-2024
Sichuan Agricultural University
2022-2024
Beijing Jishuitan Hospital
2024
Beihang University
2007-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Peking Union Medical College Hospital
2009-2024
China-Japan Friendship Hospital
2014-2024
Guizhou Provincial People's Hospital
2023
Abstract Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation macrophages around injured sensory neurons in root ganglia (DRG). Here we demonstrate critical contribution DRG macrophages, but not those at site, to both initiation maintenance mechanical hypersensitivity that characterizes neuropathic pain phenotype. In contrast reported sexual dimorphism microglial pain, depletion reduces injury-induced male female mice....
Nintendo lost its dominant position in the video game industry during console war between 64 and Sony's PlayStation. However, could have made several different strategic decisions to change outcome. This article develops a structural model investigates these alternative strategies through policy simulations. In particular, author provides framework study firms' optimal pricing under network effects, consumer heterogeneity, oligopolistic competition. Consumer heterogeneity an incentive for...
Mobile users can create word of mouth wherever they are and whenever want, leading to differences in the content consumption value mobile versus nonmobile mouth.
Abstract Our objective was to identify suitable reference genes in serum miRNA for normalization and screen potential new biomarkers osteoporosis diagnosis by a systematic study. Two types of models were used like as mechanical unloading estrogen deficiency. Through large-scale screening using microarray, qPCR validation statistical algorithms, we first identified miR-25-3p gene both type osteoporosis, which also showed stability during the differentiation processes osteoblast osteoclast....
Diaporindenes A–D (1–4), four unusual 2,3-dihydro-1H-indene isomers, a novel isoprenylisobenzofuran A (5), two new isoprenylisoindole alkaloids diaporisoindoles D and E (6 7), benzophenone derivative tenellone (11), together with known biogenetic agents (8–10 12), were all separated from the endophytic fungus Diaporthe sp. SYSU-HQ3 guided by ultraperformance liquid chromatography high-resolution mass spectrometry. The absolute configurations of 1–7 11 defined X-ray diffraction, quantum...
Sustained cardiac pressure overload-induced hypertrophy and pathological remodeling frequently leads to heart failure. Casein kinase-2 interacting protein-1 (CKIP-1) has been identified be an important regulator of cell proliferation, differentiation, apoptosis. However, the physiological role CKIP-1 in is unknown.The results echocardiography histology demonstrate that CKIP-1-deficient mice exhibit spontaneous with aging hypersensitivity hypertrophy, as well. Transgenic cardiac-specific...
Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl (2), along with seven known xanthones (3-9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY₂ isolated the leaves of Sonneratia apetala. Their structures elucidated on basis MS, 1D, 2D NMR data. Compounds 1, 3, 5, 7 showed potent immunosuppressive activity IC50 values ranging 5.9 to 9.3 μg/mL.
Identifying the interactions between disease and microRNA (miRNA) can accelerate drugs development, individualized diagnosis, treatment for various human diseases. However, experimental methods are time-consuming costly. So computational approaches to predict latent miRNA-disease eliciting increased attention. But most previous studies have mainly focused on designing complicated similarity-based miRNAs In this study, we propose a novel model, termed heterogeneous graph convolutional network...
Aims and objectives To investigate the developing course of postoperative pain in a Chinese sample patients following thoracic surgery. Background Chronic surgery including both thoracotomy video‐assisted is often reported. However, research on trends concerning this topic scarce with notable lack culturally focused studies by nurses. Design A prospective observational study. Methods The included undergoing ( n = 137) 143). Pain intensity interference function were assessed during...
Three new isocoumarins—dichlorodiaportintone (1), desmethyldichlorodiaportintone (2) and desmethyldichlorodiaportinol (3)—as well as six known analogues (4–9) were isolated from the culture of mangrove endophytic fungus Ascomycota sp. CYSK-4 Pluchea indica. Their structures elucidated by analysis spectroscopic data. The absolute configuration compounds 1 2 determined modified Mosher’s method. Compound showed significant anti-inflammatory activity inhibiting production NO in LPS-induced RAW...
Exposure to microgravity leads alterations in multiple systems, but microgravity-related changes the gastrointestinal tract and its clinical significance have not been well studied. We used hindlimb unloading (HU) mouse model simulate a condition investigated intestinal microbiota colonic epithelial cells. Compared with ground-based controls (Ctrls), HU affected fecal composition profile that was characterized by expansion of Firmicutes decrease Bacteroidetes. The colon epithelium mice...
The immune systems can be altered by spaceflight in many aspects, but microgravity-related mucosal changes and its clinical significance have not been well studied. purpose of this study was to investigate whether simulated microgravity influences the intestinal homeostasis increases susceptibility colon inflammation. hindlimb unloading (HU) mouse model used simulate condition. Three percent dextran sulfate sodium (DSS) given mice induce colitis. Compared ground control (Ctrl) mice, HU ones...
Eight new dimeric sorbicillinoids (1-3, 5-9) and 12 monomeric (10-20, 25), along with five known analogues (4 21-24), were isolated from the marine-derived fungus Trichoderma reesei 4670. Their structures elucidated on basis of extensive spectroscopic analyses (1D 2D NMR, HR-ESIMS, ECD) X-ray crystallography. Compound 1, containing a pyrrolidin-2-one moiety, is reported for first time in sorbicillinoid family. Compounds 8 9 are examples bisorbicillinoids possessing benzofuro[2,3- h]chromene...
Twelve 1, 4-naphthoquinone derivatives, including two new (1 and 2) 10 known (3–12), were obtained from endophytic fungus Talaromyces sp. SK-S009 isolated the fruit of Kandelia obovata. All structures identified through extensive analysis nuclear magnetic resonance (NMR), mass spectrometry (MS) circular dichroism (CD), as well by comparison with literature data. These compounds significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine macrophage cell...
Nitrite poses a serious threat to intensive aquaculture. Protein, as major nutrient in animals, is vital for protecting animal tissues from damage. In this study, we investigated the protective effect of dietary protein on gill tissue structure and underlying mechanisms sub-adult grass carp (Ctenopharyngodon idella) exposed nitrite stress. Six iso-energetic semi-purified diets containing different levels (16-31 %) were formulated, fed fish 60 d. The then solution 4 Histopathological...
The proactive removal of condensed clips from TikTok decreased demand for corresponding full-length originals by 3%, revealing their positive impact to TV industry.
Abstract Background Kinesiology Taping(KT) is commonly used as a physical therapy to prevent exercise-induced fatigue. This study aims evaluate the immediate effects of KT on muscle strength, static balance, and proprioception after eccentric fatigue ankle. Methods Twenty healthy male university students were recruited. The experimental protocol was structured into four sessions, each separated by one-week washout period carryover effects. Participants randomly allocated one intervention...
Before the deregulation of digital subscriber line (DSL) services by Federal Communications Commission (FCC) in 2005, phone companies were required to share their DSL bandwidth with independent providers. Despite large number providers that entered market, accounted for 95.3% all subscribers 2005. A common explanation this is based on supply-side factors such as costs faced these lease lines from companies, well price discounts offered companies. In paper, we look a demand-side market...
Lasiodiplactone A (1), an unprecedented lactone, was obtained from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. The structure of 1 established by analysis NMR spectroscopic data and electronic circular dichroism (ECD) spectra. (1) first example lactone that possesses a unique tetracyclic system (12/6/6/5) RAL12 (12-membered β-resorcylic acid lactone) with pyran ring furan ring. possible biogenetic pathway for proposed. Compound showed anti-inflammatory activity inhibiting...