A5100652790- Spaceflight effects on biology
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Ginseng Biological Effects and Applications
- Diet and metabolism studies
- Acupuncture Treatment Research Studies
- Cardiovascular Function and Risk Factors
- Peptidase Inhibition and Analysis
- Bone and Joint Diseases
- Anesthesia and Neurotoxicity Research
- Signaling Pathways in Disease
- Ion channel regulation and function
- Plasma Applications and Diagnostics
- Pain Mechanisms and Treatments
- Bone health and treatments
- RNA modifications and cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Fibrosis and Remodeling
- Genetics, Aging, and Longevity in Model Organisms
- Polyamine Metabolism and Applications
- Quinazolinone synthesis and applications
- Histone Deacetylase Inhibitors Research
- High-Temperature Coating Behaviors
China Astronaut Research and Training Center
2015-2024
Dalian University of Technology
2024
Air Force Medical University
2017-2023
China Medical University
2021-2023
China Agricultural University
2023
Zhejiang Lab
2023
Xijing Hospital
2017-2022
82th Hospital of Pla
2022
Army Medical University
2020-2022
Beijing Luhe Hospital Affiliated to Capital Medical University
2022
microRNA is necessary for osteoclast differentiation, function and survival. It has been reported that miR-199/214 cluster plays important roles in vertebrate skeletal development miR-214 inhibits osteoblast by targeting ATF4. Here, we show up-regulated during osteoclastogenesis from bone marrow monocytes (BMMs) with macrophage colony stimulating factor (M-CSF) receptor activator of nuclear factor-κB ligand (RANKL) induction, which indicates a critical role differentiation. Overexpression...
Sustained cardiac pressure overload-induced hypertrophy and pathological remodeling frequently leads to heart failure. Casein kinase-2 interacting protein-1 (CKIP-1) has been identified be an important regulator of cell proliferation, differentiation, apoptosis. However, the physiological role CKIP-1 in is unknown.The results echocardiography histology demonstrate that CKIP-1-deficient mice exhibit spontaneous with aging hypersensitivity hypertrophy, as well. Transgenic cardiac-specific...
Abstract The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with severity coronary artery calcification (CAC) and testify whether selected miRNAs could reflect obstructive disease in symptomatic patients. Patients chest pain moderated risk for (CAD) were characterized calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels clinical matched 11 CAC (CACS > 100) 6 non-CAC = 0) subjects by microarray profile. Microarray...
Background: Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain–containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role in overload–induced remodeling failure yet be determined. Methods: To examine correlation with hypertrophy, we analyzed expression patients mice subjected transverse...
Abstract Osteoclast over-activation leads to bone loss and chloride homeostasis is fundamental importance for osteoclast function. The calcium-activated channel Anoctamin 1 (also known as TMEM16A) an important involved in many physiological processes. However, its role remains unresolved. Here, we identified the existence of show that expression positively correlates with activity. Osteoclast-specific knockout mice exhibit increased mass decreased resorption. Mechanistically, deletion...
Increasing evidence indicates the occurrence of cognitive impairment in astronauts under spaceflight compound conditions, but underlying mechanisms and countermeasures need to be explored. In this study, we found that learning memory abilities were significantly reduced rats a simulated long-duration environment (SLSE), which includes microgravity, isolation confinement, noises, altered circadian rhythms. Dammarane sapogenins (DS), alkaline hydrolyzed products ginsenosides, can enhance...
Interaction between humans and the gut microbiota is important for human physiology. Here, was analyzed via metagenomic sequencing, fluctuations in under conditions of spaceflight were characterized. The composition function substantially affected by spaceflight; however, individual specificity uncompromised. We further confirmed species functional genes from both missions. Resistance virulence spaceflight, but attributions remained stable. Spaceflight markedly microbiota, implying that...
Abstract Objectives Cardiac Ca 2+ signalling plays an essential role in regulating excitation‐contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity hypergravity effects on remain unknown. Here, we elucidate mechanisms underlying proliferation remodelling HL‐1 subjected rotation‐simulated 4G hypergravity. Materials Methods The cardiomyocyte cell line was used this study. A clinostat centrifuge were study hypergravity, respectively,...
Osteonecrosis of the femoral head, an intractable but common disease that eventually triggers collapse is characterized by increased osteoclast activity and markedly decreased osteoblast in necrotic region head. MicroRNA (miRNA)-214 (miR-214) may play important roles vertebrate skeletal development inhibiting function targeting activating transcription factor 4 (ATF4) promoting via phosphatase tensin homolog (PTEN). This study revealed significantly levels miR-214 regions, with commensurate...
Abstract Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to loss. Osteoclasts are the only resorbing cells play a crucial role in remodeling. The molecular mechanisms underlying mechanical stimulation-induced changes osteoclast function remain be fully elucidated. Our previous research found Ca 2+ -activated Cl − channel Anoctamin 1 (Ano1) was an regulator function. Here, we report that Ano1 mediates responses stimulation. In vitro,...
Bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoblast function play critical roles in bone formation, which is a highly regulated process. Long noncoding RNAs (lncRNAs) perform diverse functions variety of biological processes, including BMSC differentiation. Although several studies have reported that HOX transcript antisense RNA (HOTAIR) involved differentiation, its effect on formation vivo remains unclear. Here, by constructing transgenic mice with...
Physiological adaptations to microgravity involve alterations in cardiovascular systems. These result cardiac remodeling and orthostatic hypotension. However, the response of left ventricle (LV) right (RV) following hindlimb unloading (HU) reloading (HR) is not clear underlying mechanism remains be understood. In this study, three groups mice were subjected HU by tail suspension for 28 days. Following this, two allowed recover 7 or 14 The control group was treated equally, with exception...
Abstract The CD44 is cellular surface adhesion molecule that involved in physiological processes such as hematopoiesis, lymphocyte homing and limb development. It plays an important role a variety of functions including adhesion, migration, invasion survival. In bone tissue, widely expressed osteoblasts, osteoclasts osteocytes. However, the mechanisms underlying its metabolism remain unclear. We found expression was upregulated during osteoclastogenesis. deficiency vitro significantly...
Physiological adaptations to microgravity involve alterations in cardiovascular, neuromuscular, and neuroendocrine systems. These result cardiac remodeling orthostatic hypotension. At present, the mechanism of induced by remains be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an inhibitor pressure-overload down-regulation phosphorylation HDAC4. However, role CKIP-1 unknown. The purpose this study was determine whether also involved regulation microgravity. We first detected...
To verify the beneficial effects of Nanobubbles water curcumin extract (NCE) supplementation on health promotion and to demonstrate application NCE in reducing risk musculoskeletal injury.In current study, 12 females were randomly assigned (15g/day) maltodextrin groups. Performance related body composition evaluated at 2 time points-presupplementation (pre-) after 4 weeks postsupplementation (post-). The posttest consists a set biochemical parameters for antifatigue activity injury status...
Electroacupuncture (EA) therapy has been widely reported to alleviate neuropathic pain with few side effects in both clinical practice and animal studies worldwide. However, little is known about the comparison of therapeutic efficacy among diverse EA schemes used for pain. The present study aimed at investigating discrepancy between single combined-acupoint reveal difference mechanisms behind them. was given Zusanli (ST36) Huantiao (GB30) combined group or ST36 alone group. Paw withdrawal...
We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, underlying mechanism and how CysC changes after stroke are not clear. In present study, we demonstrated expression was elevated as early 3 h reperfusion, this further enhanced HBO preconditioning. Concurrently, LC3-II Beclin-1, two positive-markers for autophagy induction, exhibited increases similar to CysC, while knockdown of blocked...
Chemokine CX3CL1 and its receptor CX3CR1 in the lumbar spinal cord play crucial roles pain processing. Electroacupuncture (EA) is recognized as an alternative therapy treatment due to efficacy safety. However, analgesic mechanism of EA remains unclear. The aim this study was investigate whether suppressed complete Freund's adjuvant (CFA)-induced via modulating CX3CL1-CX3CR1 pathway.Inflammatory induced by intraplantar injection CFA left hind paw Sprague-Dawley rats. with 2 Hz for 30 mins...
Abstract Objective Bone loss is common in AS, and miR-214 plays an important role regulating bone formation. The aim of this study was to investigate the effect miR-214, production which stimulated by IL-17A, on AS. Methods Peripheral blood obtained from 32 patients with AS 24 healthy controls. Levels soluble RANK ligand (RANKL) osteoprotegerin serum were evaluated ELISA, relative level detected real-time quantitative PCR. In addition, we assessed relationship between levels IL-17A primary...