A5107840968- Nerve injury and regeneration
- Bone and Joint Diseases
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Hip disorders and treatments
- Bone Tissue Engineering Materials
- Lower Extremity Biomechanics and Pathologies
- Orthopaedic implants and arthroplasty
- Silk-based biomaterials and applications
- Plant Pathogenic Bacteria Studies
- Mesenchymal stem cell research
- Plant-Microbe Interactions and Immunity
- Magnesium Alloys: Properties and Applications
- Tendon Structure and Treatment
- Orthopedic Infections and Treatments
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Bone fractures and treatments
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Wireless Body Area Networks
- Ubiquitin and proteasome pathways
- Laser Applications in Dentistry and Medicine
- Neuroscience and Neural Engineering
- Connective tissue disorders research
Chinese PLA General Hospital
2015-2025
Shandong Agricultural University
2024
Nantong University
2017-2023
Chinese People's Liberation Army
2010-2019
People's Liberation Army No. 150 Hospital
2014-2018
The 309th Hospital of Chinese People's Liberation Army
2016
Chinese University of Hong Kong
2010-2015
Chinese General Hospital College of Nursing and Liberal Arts
2007
MicroRNAs have an important role in bone homeostasis. However, the detailed mechanism of microRNA-mediated intercellular communication between cells remains elusive. Here, we report that osteoclasts secrete microRNA-enriched exosomes, by which miR-214 is transferred into osteoblasts to inhibit their function. In a coculture system, inhibition exosome formation and secretion prevented transportation. Exosomes specifically recognized through interaction ephrinA2 EphA2. osteoclast-specific...
Abstract In initial work, we developed a 14-day culture protocol under potential GMP, chemically defined conditions to generate chondroprogenitors from human embryonic stem cells (hESCs). The present study was undertaken investigate the cartilage repair capacity of these cells. chondrogenic optimized and validated with gene expression profiling. also applied successfully two lines induced pluripotent (iPSCs). Chondrogenic derived hESCs were encapsulated in fibrin gel implanted osteochondral...
Abstract Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic resorption. Dysregulation of this process leads to multiple diseases, including osteoporosis. However, underlying molecular mechanisms are not fully understood. Here, we show that global conditional osteoblast knockout a deubiquitinase Otub1 result in low mass poor strength due defects osteogenic differentiation mineralization. Mechanistically, stability FGFR2, crucial regulator...
A favorable regenerative microenvironment is essential for peripheral nerve regeneration. Neural tissue-specific extracellular matrix (ECM) a natural material that helps direct cell behavior and promote axon Both bone marrow-derived mesenchymal stem cells (BMSCs) adipose-derived (ADSCs) transplantation are effective in repairing injury (PNI). However, there no study characterizes the vivo microenvironmental characteristics of these two MSCs early repair PNI when combined with neural...
Abstract Low intensity pulsed ultrasound (LIPUS) has been widely used in clinic for the treatment of repairing pseudarthrosis, bone fractures and healing various soft tissues. Some reports indicated that LIPUS accelerated peripheral nerve regeneration including Schwann cells (SCs) injured nerves. But little is known about its appropriate intensities on autograft This study was to investigate which improved gold standard postsurgical nerves experimental rat model. Sprague-Dawley rats were...
Compared with most nondegradable or slowly degradable bone repair materials, bioactive biodegradable porous scaffolds certain mechanical strengths can promote the regeneration of both new and vasculature while cavity created by their degradation be replaced infiltration tissue. Mineralized collagen (MC) is basic structural unit tissue, silk fibroin (SF) a natural polymer adjustable rates superior properties. In this study, three-dimensional biomimetic composite scaffold two-component SF-MC...
Fractures of the orbital floor are common in traffic accidents and assaults, inadequate treatment can result serious complications. Accurate anatomical reconstruction orbit using implants is preferred treatment. Implants require degradability, adequate mechanical properties to support contents, osteoinductivity or osteoconductivity so that implant replaced by de novo bone over time. Here, we report on a semi‐automatic process for generation virtual models patient‐specific reconstruction....
Thermosensitive hydrogels have been studied for potential application as promising alternative cell carriers in cell-based regenerative therapies. In this study, a thermosensitive butane diisocyanate (BDI)-collagen hydrogel (BC hydrogel) was designed an injectable delivery carrier of tendon stem/progenitor cells (TSPCs) tissue engineering. We functionalized the BDI with addition 20% (v/v) collagen I gel to obtain BC hydrogel, which then seeded TSPCs derived from human Achilles tendons. The...
Background: The Catharanthus roseus receptor-like kinase 1-like (CrRLK1L) subfamily, a specialized group within kinases (RLKs), was initially identified in C. cell cultures. CrRLK1L plays an important role the growth, development and stress response of plants. Although genes have been characterized across multiple plant species, their biological genetic functions potatoes (Solanum tuberosum) remains poorly elucidated. Methods: genome-wide investigation, phylogenetic analysis, chromosome...
<title>Abstract</title> Artificial neural pathway (ANP) implants hold transformative potential for empowering individuals with disabilities, which has recently revolutionized the clinical treatment of spinal cord injury through epidural electrical stimulation (EES). Classical EES operates a pre-set program and needs manual modification, consuming both manpower time. Although existed studies proposed kinematic image processing to configurate or brain-spine interface control motions...
The emu, a large bipedal bird with hip joint biomechanics similar to humans, was used establish an experimental model of femoral head osteonecrosis and subsequent collapse. Focal lesions were induced in 20 adult male emus using alternating liquid nitrogen freezing radiofrequency heating insult. At 2, 4, 8, 12 16 weeks post-surgery, magnetic resonance imaging (MRI) performed. Before the sacrificed, barium sulphate infused lower extremity study blood vessel distribution patterns. Femoral...
In this study we established a bipedal animal model of steroid-associated hip joint collapse in emus for testing potential treatment protocols to be developed prevention preclinical settings. Five adult male were treated with osteonecrosis (SAON) induction protocol using combination pulsed lipopolysaccharide (LPS) and methylprednisolone (MPS). Additional three used as normal control. Post-induction, emu gait was observed, magnetic resonance imaging (MRI) performed, blood collected routine...
To develop a vaccine-based immunotherapy for sarcoma, we evaluated mixture of heat shock proteins (mHSPs) as vaccine sarcoma treatment in mouse model. Heat protein/peptides (HSP/Ps) are autoimmune factors that can induce both adaptive and innate immune responses; HSP/Ps isolated from tumors antitumor activity when used vaccines.In this study, the effects mHSP/Ps on prophylactic immunity. We extracted mHSP/Ps, including HSP60, HSP70, GP96, HSP110, cell lines S180 MCA207 using chromatography....
Summary Type‐3 effectors (T3E) of phytopathogenic Gram‐negative bacteria fulfill a virulent role, causing disease, or an avirulent inducing immunity, following their translocation into plant cells. This study aimed to validate the hypothesis that bacterial T3E requires lipidic compounds in cell membranes. Based on genetic, molecular, and biochemical assays, we determined phosphatidylinositol 4‐phosphate (PI4P) associated with membranes is essential for by pathogens. Replicate experimental...