A5079399944- Stellar, planetary, and galactic studies
- Astro and Planetary Science
- Cancer-related molecular mechanisms research
- Astronomy and Astrophysical Research
- Medicinal Plant Pharmacodynamics Research
- RNA modifications and cancer
- Asthma and respiratory diseases
- Ion channel regulation and function
- Astrophysics and Star Formation Studies
- Bone Metabolism and Diseases
- Cancer-related Molecular Pathways
- Cardiac electrophysiology and arrhythmias
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Immune Response and Inflammation
- Plant tissue culture and regeneration
- Phytochemical compounds biological activities
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Erythrocyte Function and Pathophysiology
- Space Exploration and Technology
- Pluripotent Stem Cells Research
- interferon and immune responses
- Cellular transport and secretion
- Bone and Joint Diseases
Guilin Medical University
2017-2025
Purple Mountain Observatory
2012-2024
Fifth Hospital of Shijiazhuang
2024
Center for Excellence in Molecular Cell Science
2021-2024
Beijing Chao-Yang Hospital
2024
Capital Medical University
2024
University of California, Davis
2011-2023
Chinese Academy of Forestry
2023
Guangxi Zhuang Autonomous Region Department of Education
2023
Institute of Forest Ecology, Environment and Protection
2023
Long non-coding RNAs (lncRNAs) have been studied extensively over the past few years. Large numbers of lncRNAs identified in mouse, rat, and human, some them shown to play important roles muscle development myogenesis. However, there are reports on characterization covering all stages skeletal livestock. RNA libraries constructed from developing longissimus dorsi fetal (45, 60, 105 days gestation) postnatal (3 after birth) goat (Capra hircus) were sequenced. A total 1,034,049,894 clean reads...
The Closeby Habitable Exoplanet Survey (CHES) mission is proposed to discover habitable-zone Earth-like planets of the nearby solar-type stars ($\sim 10~\mathrm{pc}$ away from our solar system) via micro-arcsecond relative astrometry. major scientific objectives CHES are: search for Earth Twins or terrestrial in habitable zones orbiting 100 FGK stars; further conduct a comprehensive survey and extensively characterize planetary systems. primary payload high-quality, low-distortion,...
近邻宜居行星巡天计划(Closeby Habitable Exoplanet Survey, CHES)采用空间微角秒级别的高精度天体测量技术, 普查太阳系近邻(10 pc内)约100颗FGK等类型恒星, 探测宜居带类地行星或超级地球; 详细普查宜居行星的数目、真实质量和三维轨道等信息, 这将是国际上首次近邻宜居带类地行星的空间探测任务. CHES的有效载荷是一台口径为1.2 m, 视场为0.44°×0.44°, 焦距为36 m的高像质、低畸变、高稳定光学望远镜, 采用同轴三反TMA光学成像系统. 为实现宜居带类地行星探测, CHES任务中的测量精度为1 μas, 是目前国际测量精度最高的空间探测项目. 在空间科学先导专项背景型号项目的支持下, CHES团队深入凝练和论证科学目标, 成功突破了三项关键技术难题: 实现了畸变大视场高像质空间望远镜光学系统技术的重要突破; 突破了10<sup>–5</sup> pixel级别星间距测量技术; 实现了卫星系统高稳定度姿态控制精度及热控精度的创新. CHES预计发现50颗类地行星, 引领中国空间科学探测技术的跨越式发展.
Abstract This study was designed to develop a bioactive scaffold enhance bone defect repair in steroid‐associated osteonecrosis (SAON). Icaritin, metabolite of the herb Epimedium , has been identified as an angiogenic and osteogenic phytomolecule. Icaritin homogenized into poly lactic‐ co ‐glycolic acid/tricalcium phosphate (PLGA/TCP) form icaritin‐releasing porous composite (PLGA/TCP/icaritin) by fine‐spinning technology. In vitro, high performance liquid chromatography used determine...
Abstract Background Sox6 is a multi-faceted transcription factor involved in the terminal differentiation of many different cell types vertebrates. It has been suggested that mice as well zebrafish plays role skeletal muscle by suppressing slow fiber specific genes. In order to understand how coordinately regulates multiple type genes during development, we have performed ChIP-seq analyses identify target mouse fetal myotubes and generated muscle-specific knockout (KO) determine null...
We found that Icaritin, an intestinal metabolite of Epimedium-derived flavonoids (EF) enhanced osteoblastic differentiation mesenchymal stem cells (MSCs) only under osteogenic induction conditions. also demonstrated its effect on inhibition adipogenic MSCs. Unlike the findings others EF compounds, we showed Icaritin was unable to promote proliferation, migration and tube like structure formation by human umbilical vein endothelial (HUVECs) in vitro. These results suggested exogenous...
Nondioxin-like polychlorinated biphenyls (NDL PCBs) activate ryanodine-sensitive Ca 2þ channels (RyRs) and this activation has been associated with neurotoxicity in exposed animals.RyR-active congeners follow a distinct structure-activity relationship quantitative (QSAR) predicts that large number of PCBs likely the receptor, which requires validation.Additionally, previous structural based conclusions have established using receptor ligand binding assays but impact varying PCB structures on...
Nineteen ortho-substituted PCBs are chiral and found enantioselectively enriched in ecosystems. Their differential actions on biological targets not understood. PCB 95 (2,2′,3,5′,6-pentachlorobiphenyl), a of current environmental relevance, is among the most potent toward modifying ryanodine receptors (RyR) function Ca2+ signaling. enantiomers separated assigned aR- aS-PCB using three chiral-column HPLC circular dichroism spectroscopy. Studies RyR1-enriched microsomes show aR-PCB with >4×...
Non–dioxin like polychlorinated biphenyls (NDL-PCBs) are legacy environmental contaminants with contemporary unintentional sources. NDL-PCBs interact ryanodine receptors (RyRs), Ca2+ channels of sarcoplasmic/endoplasmic reticulum (SR/ER) that regulate excitation-contraction coupling (ECC) and Ca2+-dependent cell signaling in muscle. Activities 4 chiral congeners PCB91, 95, 132, 149 their respective 4- 5-hydroxy (-OH) derivatives toward rabbit skeletal muscle receptor (RyR1) investigated...
Abstract The Closeby Habitable Exoplanet Survey (CHES) is dedicated to the astrometric exploration for habitable-zone Earth-like planets orbiting solar-type stars in close proximity, achieving unprecedented microarcsecond precision. Given elevated precision, meticulous consideration of photocenter jitters induced by stellar activity becomes imperative. This study endeavors model stars, compute noise, and delineate detection limits habitable within domain. Simulations were conducted...
Skeletal muscle development is a complex biological process regulated by numerous genes and non-coding RNAs, such as microRNAs (miRNAs). In the current study, we made use of deep sequencing data from Jianzhou Da'er goat longissimus dorsi sampled on days 45, 60, 105 gestation, well day three after birth to identify miRNAs that regulate skeletal myogenesis, examine their temporal expression profiles. A total 410 known miRNAs, 752 miRNA homologs 88 novel were identified across four stages....
Purpose Recent studies have demonstrated that macrophage migration inhibitory factor (MIF) is of importance in asthmatic inflammation. The role MIF modulating airway remodeling has not yet been thoroughly elucidated to date. In the present study, we hypothesized promoted by intensifying smooth muscle cell (ASMC) autophagy and explored specific mechanisms. Methods knockdown lung tissues C57BL/6 mice was conducted instilling intratracheally adeno-associated virus (AAV) vectors (MIF-mutant...
Abstract Background The deposition of Aβ 42 has been regarded as one the important pathological features Alzheimer’s disease (AD). However, drug development for toxicity progressed slowly. Objective Our aim was to introduce effect and related mechanism trehalose on an arc (arctic mutant ) Drosophila AD model. Methods human expressed in construct Trehalose added culture vial. movement ability determined by detecting climbing flight ability. Enzyme-linked immunosorbent assay used detect levels...
Abstract Background Bronchial asthma, a chronic inflammatory airway disease, is characterized by remodeling, including thickening of the smooth muscle layer, primarily due to abnormal proliferation cells (ASMCs). CBL0137 (Curaxin-137 hydrochloride), histone chaperone facilitate chromatin transcription (FACT) inhibitor, has demonstrated anti-tumor properties, inhibition proliferation, promotion apoptosis, and increased autophagy. However, its effects on ASMCs remodeling remain unexplored....
Abstract Given that secular perturbations in a binary system not only excite high orbital eccentricities but also alter the planetary inclination, classical Keplerian model is no longer applicable for retrieval. The combination of dynamical and observational data essential characterizing configuration mass close binaries. We calculate theoretical radial velocity (RV) signal N -body framework observe drift RV semiamplitude, which leads to reduction m sin i detection threshold by 20 M ⊕ , with...
We investigate by numerical methods the tidal evolution of Kepler-10 system, which consists an inner rocky planet and outer terrestrial planet, considering various initial eccentricity pairs that follow conservation angular momentum system. Our results cover range all reasonable eccentricities with mass ratios two planets for system; can produce present observed orbits within certain errors. Additional simulations alternate values dissipation factor Q′1 are carried out, where may be...
Because NSCLC has poor overall prognosis and is frequently diagnosed at later stage, we aimed to seek novel diagnosis biomarkers or therapy target of the disease in this study. Fructose-1,6-bisphosphatase 1 (FBP1) a rate-limiting enzyme gluconeogenesis, which was usually lost due abnormal methylation promoter DNA sequence. The clinical data indicated that rate FBP1 gene negatively related survival patients. transferase inhibitor 5-aza treatment could significantly increase both expression...