A5030554560- Advanced SAR Imaging Techniques
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Radar Systems and Signal Processing
- Nerve injury and regeneration
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Landslides and related hazards
- Cancer Cells and Metastasis
- Proteoglycans and glycosaminoglycans research
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Protease and Inhibitor Mechanisms
- Target Tracking and Data Fusion in Sensor Networks
- Cellular Mechanics and Interactions
- Soil Moisture and Remote Sensing
- Structural Health Monitoring Techniques
- Microwave Imaging and Scattering Analysis
- Neuroscience and Neural Engineering
- Bone and Dental Protein Studies
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Cryospheric studies and observations
- Cancer Research and Treatments
- Inertial Sensor and Navigation
Harbin Institute of Technology
2016-2025
Beijing Institute of Technology
2014-2024
Southern Medical University
2024
Chongqing University of Technology
2021-2023
Chongqing Three Gorges University
2021
Harbin University
2016
University of Saskatchewan
2013
Air Force Medical University
2013
Xijing Hospital
2013
China Astronaut Research and Training Center
2012
MicroRNAs have an important role in bone homeostasis. However, the detailed mechanism of microRNA-mediated intercellular communication between cells remains elusive. Here, we report that osteoclasts secrete microRNA-enriched exosomes, by which miR-214 is transferred into osteoblasts to inhibit their function. In a coculture system, inhibition exosome formation and secretion prevented transportation. Exosomes specifically recognized through interaction ephrinA2 EphA2. osteoclast-specific...
Brain tissue engineering in the postinjury brain represents a promising option for cellular replacement and rescue, providing cell scaffold either transplanted or resident cells. In this article, hyaluronic acid (HA)–poly-D-lysine (PDL) copolymer hydrogel with an open porous structure viscoelastic properties similar to neural has been developed engineering. The chemicophysical of HA:PDL ratios 10:1, 5:1, 4:1 were investigated by scanning electron microscopy (SEM) X-ray photoelectron...
Neural stem cells (NSCs) are considered as candidates for cell replacement therapy in many neurological disorders. However, the propensity their differentiation to proceed more glial rather than neuronal phenotypes pathological conditions limits positive outcomes of reparative transplantation. Exogenous physical stimulation favor NSCs without extra chemical side effect could alleviate problem, providing a safe and highly efficient accelerate recovery following injuries.With 7-day...
Abstract The main hallmark of myocardial substrate metabolism in cardiac hypertrophy or heart failure is a shift from fatty acid oxidation to greater reliance on glycolysis. However, the close correlation between glycolysis and underlying mechanism by which causes pathological remodelling remain unclear. We confirm that KLF7 simultaneously targets rate-limiting enzyme glycolysis, phosphofructokinase-1, liver, long-chain acyl-CoA dehydrogenase, key for oxidation. Cardiac-specific knockout...
A biocompatible hydrogel of hyaluronic acid with the neurite-promoting peptide sequence IKVAV was synthesized. The characterization shows an open porous structure and a large surface area available for cell interaction. Its ability to promote tissue repair axonal regeneration in lesioned rat cerebrum is also evaluated. After implantation, polymer repaired defect formed permissive interface host tissue. Axonal growth occurred within microstructure network. Within 6 weeks implant invaded by...
Myocardial ischemia-reperfusion (IR) injury is a severe rhythmic disease with high prevalence in the early morning. IR has significant circadian rhythm reactive oxygen species (ROS) and inflammation levels. The development of drugs become priority myocardial injury. In this study, resveratrol (RES) proanthocyanidins (OPC) were utilized to design nanoparticles (NPs), hyaluronic acid (HA) as core, grafted MMP-targeting peptides improve delivery injured regions (HA-RES-OPC-MMP NPs). NPs...
The incidence of atherosclerosis (AS), a major contributor to cardiovascular disease, is steadily rising along with an increasingly older population worldwide. Pyroptosis, form inflammatory programmed cell death, determines the release pro-inflammatory mediators by endothelial cells, smooth muscle and atheroma-associated macrophages foam thereby playing critical role in AS progression. Canonical pyroptosis mediated inflammasome formation, activation caspase-1, maturation proinflammatory...
The objective of the study was to determine effects a hyaluronic-acid-based (HA-based) hydrogel implant, carrying polyclonal antibody Nogo-66 receptor (NgR), on adult rats that underwent middle cerebral artery occlusion (MCAO). Behavioral tests forelimb-reaching task suggested disabled function impaired forelimb in this stroke model ameliorated by implant certain extent. These behavioral findings were correlated with immunohistochemical results investigating distribution NgR antibody,...
Cardiac tissue engineering holds great promise for the treatment of myocardial infarction. However, insufficient cell migration into scaffolds used and inflammatory reactions due to scaffold biodegradation remain as issues be addressed. Engineered heart (EHT) grafts fabricated by means a encapsulation technique provide cells with tissue-like environment, thereby potentially enhancing cellular processes such migration, proliferation, differentiation, regeneration. This paper presents study on...
This paper analyzes the multiangle imaging results for bistatic synthetic aperture radar (BSAR) based on global navigation satellite systems (GNSS-BSAR). Due to shortcoming of GNSS-BSAR images, a observation and data processing strategy BeiDou-2 satellites was put forward improve quality images value system application. Twenty-six BSAR experiments were conducted analyzed in different configurations. Furthermore, region-based fusion algorithm using region-of-interest (ROI) segmentation...
Hyaluronan (HA), a polymer with various molecular weights (MW) found in tumor microenvironments, is associated malignant progression of breast cancer. Reducing the amount high-MW HA microenvironment by hyaluronidase promising approach for cancer treatment. However, whether generation fragments negatively affects cells remains to be determined. Furthermore, forms three-dimensional (3D) networks cross-linking other extracellular molecules function. Therefore, model mimicking cross-linked...
Abstract: Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) insulin-like growth factor 1 (IGF-1) are two potent factors that promote cardiomyocyte survival proliferation. However, their delivery for sustained release MI-affected areas has proved to be challenging. In the current research, we present a study on co-delivery BIO IGF-1 hybrid hydrogel system simulate...
Thrombospondin-2 (TSP2) is an inhibitor of angiogenesis with pro-apoptotic and anti-proliferative effects on endothelial cells. Mice deficient in this matricellular protein display improved recovery from ischemia accelerated wound healing associated alterations extracellular matrix remodeling. In study, we probed the function TSP2 by performing a detailed analysis dermal wounds wound-derived fibroblasts. Specifically, analyzed incisional tensiometry found no differences strength between...
Calcium cross-linked alginate hydrogel has shown positive results for the treatment of myocardial infarction in both acute and chronic rat models. However, hydrogels possess poor mechanical properties, uncontrollable degradation, cell adhesion infiltration. In this study, covalent cross-linking partially oxidized gelatin was developed treatment, as compared to saline. Specifically, gelation process, biodegradation were examined vitro vivo; a model by injecting into hearts, postinjection,...
Abstract: Instead of killing cancer stem cells (CSCs), the conventional chemotherapy used for treatment promotes enrichment CSCs, which are responsible tumor growth, metastasis, and recurrence. However, most therapeutic agents only able to kill a small proportion CSCs by targeting one or two cell surface markers dysregulated CSC pathways, usually shared with normal (NSCs). In this study, we developed novel nondrug delivery system dual conjugating hyaluronic acid (HA) grafting...
Engineering scaffolds with a structure mimicking that of native cornea allows for addressing the severe donor shortage corneal blindness treatment, which, however, remains challenging. In light stromal (CS) cells can play key role in stroma formation, this study we incorporated CS into three-dimensional (3D) printed from hyaluronic acid-modified gelatin-methacrylate (GelMA-HA) and characterized terms remodeled extracellular matrix (ECM) vitro. Our results illustrated modification GelMA by HA...