A5103282614- Spaceflight effects on biology
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Ginseng Biological Effects and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Asthma and respiratory diseases
- IgG4-Related and Inflammatory Diseases
- Osteoarthritis Treatment and Mechanisms
- Neuroendocrine Tumor Research Advances
- Endometriosis Research and Treatment
- Anesthesia and Neurotoxicity Research
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Peptidase Inhibition and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Function and Risk Factors
- Gastrointestinal disorders and treatments
- Medicinal Plants and Bioactive Compounds
- Reproductive System and Pregnancy
- Ion channel regulation and function
- Immune cells in cancer
Nanjing University of Chinese Medicine
2022-2025
Dongfeng Motor (China)
2025
Yunnan University
2025
Shaoxing People's Hospital
2025
Taizhou Municipal Hospital
2013-2024
Ningbo University
2024
Ningbo University Affiliated Hospital
2023-2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Harbin Medical University
2019-2024
Abstract Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and they play fundamental roles in immune regulation. Here we introduce an integrated algorithm, ImmLnc, for identifying lncRNA immune-related pathways. We comprehensively chart the landscape regulation immunome across 33 cancer types show that cancers with similar tissue origin likely to share regulators. Moreover, lncRNAs perturbation significantly correlated cell infiltration. ImmLnc can help...
Mechanical load of the skeleton system is essential for development, growth, and maintenance bone. However, molecular mechanism by which mechanical stimuli are converted into osteogenesis bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer critical various biological processes, plays role in formation. Knockout Piezo1 osteoblast lineage cells disrupts osteoblasts severely impairs structure strength. Bone loss induced unloading blunted knockout mice....
Rationale: Breast cancer preferentially develops osteolytic bone metastasis, which makes patients suffer from pain, fractures and spinal cord compression. Accumulating evidences have shown that exosomes play an irreplaceable role in pre-metastatic niche formation as a communication messenger. However, the function of secreted by breast cells remains incompletely understood metastasis cancer. Methods: Mouse xenograft models intravenous injection were applied for analyzing cell-derived vivo....
Background Neutrophils-linked premetastatic niche plays a key role in tumor metastasis, but not much is known about the heterogeneity and diverse of neutrophils formation. Our study focuses on existence biological function rarely delved subset neutrophils, named as tumor-associated aged (Naged, CXCR4 + CD62L low ), involved formation during breast cancer metastasis. Methods We explored distributions Naged 206 patients mice models (4T1 MMTV-PyMT) by flow cytometry. The ability to form...
Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances strength, whereas unloading leads to loss. Increasing evidence has demonstrated that long noncoding RNAs (lncRNAs) play key roles diverse biological, physiological and pathological contexts. However, the of lncRNAs mechanotransduction their relationships with formation remain unknown. In this study, we screened mechanosensing osteoblasts identified Neat1, most clearly decreased...
Abstract The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with severity coronary artery calcification (CAC) and testify whether selected miRNAs could reflect obstructive disease in symptomatic patients. Patients chest pain moderated risk for (CAD) were characterized calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels clinical matched 11 CAC (CACS > 100) 6 non-CAC = 0) subjects by microarray profile. Microarray...
Abstract Triple-negative breast cancer (TNBC) is highly aggressive, difficult to treat and commonly develops visceral metastasis, including lung metastasis. We observed that High mobility group box 1 protein (HMGB1) was expressed in human TNBC positively correlated with The hypoxic tumor environment known regulate HMGB1 secretion, but an understanding of the underlying mechanism by which tumor-derived regulates interstitial components promotes metastasis has remained elusive. results present...
In this article, a series of novel quinoline derivatives ursolic acid (UA) bearing hydrazide, oxadiazole, or thiadiazole moieties were designed, synthesised, and screened for their in vitro antiproliferative activities against three cancer cell lines (MDA-MB-231, HeLa, SMMC-7721). A number compounds showed significant activity at least one line. Among them, compound 4d exhibited the most potent with IC50 values 0.12 ± 0.01, 0.08 0.34 0.03 μM, respectively. particular, could induce apoptosis...
Abstract Long noncoding RNAs (lncRNA) play important roles in maintaining morphology and function of tissues, their regulatory effectiveness is closely associated with spatial expression. To provide a comprehensive atlas expression for lncRNA, we propose LncSpA (http://bio-bigdata.hrbmu.edu.cn/LncSpA) to explore tissue-elevated (TE) lncRNA across human normal adult pediatric cancer tissues. In total, 71,131 12,007 TE lncRNAs 634 clinical-related were identified 38 33 Moreover, 4,688 413...
Background: Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain–containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role in overload–induced remodeling failure yet be determined. Methods: To examine correlation with hypertrophy, we analyzed expression patients mice subjected transverse...
Exosomal long non-coding RNAs (lncRNAs) serve as excellent candidate biomarkers for clinical applications. The expression of differentiation antagonizing non-protein coding RNA (DANCR) has been shown to be decreased in breast cancer (BC) tissues and cell lines. However, the value circulating exosomal DANCR BC not explored.A total 120 patients, 70 benign disease (BBD) 105 healthy women were recruited this study. Total was extracted from serum samples, level lncRNA evaluated by quantitative...
Abstract Osteoclast over-activation leads to bone loss and chloride homeostasis is fundamental importance for osteoclast function. The calcium-activated channel Anoctamin 1 (also known as TMEM16A) an important involved in many physiological processes. However, its role remains unresolved. Here, we identified the existence of show that expression positively correlates with activity. Osteoclast-specific knockout mice exhibit increased mass decreased resorption. Mechanistically, deletion...
A potential role of berberine, a benzyl isoquinoline alkaloid, in cancer therapy is apparent. Its underlying mechanisms berberine against breast carcinoma under hypoxia have not been elucidated. We focused on the doubt how restrains vitro and vivo. molecular analysis microbiome via 16 S rDNA gene sequencing DNA from mouse faeces confirmed that abundances diversity gut microbiota were significantly altered 4T1/Luc mice with higher survival rate following treatment. metabolome liquid...
Background:Homeobox A10 (HOXA10), a key transcription factor, plays critical role in endometrial receptivity by regulating the expression of downstream target genes, such as β3-integrin (ITGB3), but little is understood about mechanisms posttranslational modification HOXA10 during embryo implantation.
Increasing evidence indicates the occurrence of cognitive impairment in astronauts under spaceflight compound conditions, but underlying mechanisms and countermeasures need to be explored. In this study, we found that learning memory abilities were significantly reduced rats a simulated long-duration environment (SLSE), which includes microgravity, isolation confinement, noises, altered circadian rhythms. Dammarane sapogenins (DS), alkaline hydrolyzed products ginsenosides, can enhance...
Interaction between humans and the gut microbiota is important for human physiology. Here, was analyzed via metagenomic sequencing, fluctuations in under conditions of spaceflight were characterized. The composition function substantially affected by spaceflight; however, individual specificity uncompromised. We further confirmed species functional genes from both missions. Resistance virulence spaceflight, but attributions remained stable. Spaceflight markedly microbiota, implying that...
Abstract Translational control is crucial for protein production in various biological contexts. Here, we use Ribo-seq and RNA-seq to show that genes related oxidative phosphorylation are translationally downregulated during heart regeneration. We find Nat10 regulates the expression of Uqcr11 Uqcrb mRNAs mouse human cardiomyocytes. In mice, overexpression cardiomyocytes promotes cardiac regeneration improves function after injury. Conversely, treating neonatal mice with Remodelin—a...
<div class="section abstract"><div class="htmlview paragraph">Hydrogen energy is the best form of to achieve "carbon peak, carbon neutrality", and known as most promising clean in 21st century because its diverse sources, low-carbon, flexible efficient, wide application sce-narios. Hydrogen internal combustion engine has advantages zero emission, high efficiency, reliability low cost, become one important directions hydrogen application. The paper first analyzes development...
Obesity and its related diseases severely threaten people's health, causing persistently high morbidity mortality worldwide. The abnormal proliferation hypertrophy of adipocytes mediate the expansion adipose tissue, which is main cause obesity-related diseases. Inhibition cell during mitotic clonal (MCE) period adipogenesis may be a promising strategy for preventing treating obesity. Arthrocolins are series fluorescent dye-like complex xanthenes from engineered Escherichia coli, with...
To observe the efficacy of combination therapy with Penpulimab and Anlotinib in treatment retroperitoneal well-differentiated liposarcoma. Retrospective analysis clinical data a patient soft tissue sarcoma admitted to Shaoxing People’s Hospital, review relevant literature. The is young male who experienced recurrence liposarcoma after two surgeries. After first-line combined Penpulimab, achieved almost complete remission progression free survival period about 16 months. using resulted good prognosis.