A5100419343- Cancer-related molecular mechanisms research
- Pituitary Gland Disorders and Treatments
- Quantum Chromodynamics and Particle Interactions
- Knee injuries and reconstruction techniques
- MicroRNA in disease regulation
- Total Knee Arthroplasty Outcomes
- Particle physics theoretical and experimental studies
- Fibroblast Growth Factor Research
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Black Holes and Theoretical Physics
- High-Energy Particle Collisions Research
- Kruppel-like factors research
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Sports injuries and prevention
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Acute Lymphoblastic Leukemia research
- Lower Extremity Biomechanics and Pathologies
- Molecular Biology Techniques and Applications
- Childhood Cancer Survivors' Quality of Life
- Head and Neck Surgical Oncology
Peking University
2011-2025
Peking University Third Hospital
2010-2025
Beijing Sport University
2025
Xinxiang Medical University
2015-2025
Qiqihar Medical University
2017-2025
Beijing Municipal Education Commission
2025
First Affiliated Hospital of Xinxiang Medical University
2017-2024
Inner Mongolia Medical University
2014-2024
Hebei Medical University
2013-2024
Xingtai People's Hospital
2021-2024
Background Neutrophils-linked premetastatic niche plays a key role in tumor metastasis, but not much is known about the heterogeneity and diverse of neutrophils formation. Our study focuses on existence biological function rarely delved subset neutrophils, named as tumor-associated aged (Naged, CXCR4 + CD62L low ), involved formation during breast cancer metastasis. Methods We explored distributions Naged 206 patients mice models (4T1 MMTV-PyMT) by flow cytometry. The ability to form...
Abstract Micropeptides hidden in long non-coding RNAs (lncRNAs) have been uncovered to program various cell-biological changes associated with malignant transformation-glioblastoma (GBM) cascade. Here, we identified and characterized a novel micropeptide implicated GBM. We screened potential candidate lncRNAs by establishing workflow involving ribosome-bound lncRNAs, publicly available MS/MS data, prognosis-related lncRNAs. Micropeptide expression was detected western blot (WB),...
Protein-DNA recognition is a central biological process that governs the life of cells. A protein will often undergo conformational transition to form functional complex with its target DNA. The dynamics are expected contribute stability and specificity DNA therefore may control activity protein-DNA complex. Understanding how influences still challenging. Here, we developed two-basin structure-based model explore in Sulfolobus solfataricus Y-family polymerase IV (DPO4) during binding With...
Impaired function of the Ikaros (IKZF1) protein is associated with development high-risk B-cell precursor acute lymphoblastic leukemia (B-ALL). The mechanisms tumor suppressor activity in are unknown. binds to upstream regulatory elements its target genes and regulates their transcription via chromatin remodeling. Here, we report that represses histone H3K4 demethylase, JARID1B (KDM5B). Transcriptional repression increased global levels trimethylation. Ikaros-mediated dependent on...
Skin wound healing is a complex process requiring the coordinated behavior of many cell types, especially in proliferation and migration fibroblasts. Basic fibroblast growth factor (bFGF) member FGF family that promotes migration, but underlying molecular mechanism remains elusive. The present RNA sequencing study showed expression levels several canonical Wnt pathway genes, including Wnt2b, Wnt3, Wnt11, T-cell 7 (TCF7), Frizzled 8 (FZD8) were modified by bFGF stimulation ELISA analysis also...
Background Owing to the long penetration depth of gamma (γ)-rays, individuals working in ionizing radiation environments are chronically exposed low-dose γ-radiation, resulting cognitive changes. Dose rate significantly affects radiation-induced biological effects; however, its role chronic γ-irradiation-induced impairment remains unclear. We aimed investigate whether γ-irradiation at low-dose-rate (LDR) could induce and compare alteration caused by LDR high-dose-rate (HDR). Methods The rats...
Anterior cruciate ligament (ACL) rupture and patellar dislocation (PD) are common knee injuries. Dual-energy X-ray absorptiometry (DXA) computed tomography (CT) widely used clinical diagnostic tools. The aim was to investigate the characteristics of bone mineral density (BMD) in patients with ACL PD explore relationship between BMD Hounsfield unit (HU) values. This prospective cross-sectional study included 32 assessed via DXA CT. CT measurements were taken from regions interest femoral...
A novel [3+3] cyclization reaction between phenol and hydrazone was successfully developed under electrochemically driven conditions. This provided access to a diverse array of 1,3,4-oxadiazinane compounds in consistently high yields, reaching up 87%. Notably, the exhibited remarkable tolerance toward broad spectrum both substrates, underscoring its versatility. Moreover, protocol distinguished itself by exceptional atom step economy, facilitating efficient construction functionalized...
During X chromosome inactivation (XCI), Xist RNA establishes silencing by coating the in cis and binding diverse proteins to promote formation of a heterochromatic domain. However, repeat B role beyond initiation XCI remains unclear. Here, we find that loss female mice allows survival leads small body size persisting throughout life. Epigenetic transcriptomic analyses reveal low levels H3K27me3 H2AK119ub occupancy on chromosome, except certain CpG island regions, partial reactivation...
Fibroblast growth factors (FGFs) and their high-affinity receptors contribute to autocrine paracrine stimulation in several human malignant tumors, including breast cancer. However, the mechanisms underlying carcinogenic actions of FGF18 remain unclear.The transcription level under hypoxic condition was detected with quantitative PCR (qPCR). A wound-healing assay performed assess role cell migration. clonogenicity used determine whether silencing affected clonogenicity. Western blotting...
Nonfunctioning pituitary adenomas (NFPAs) are the major cause of hypopituitarism and infertility. However, pathogenesis NFPAs remains largely unknown. Previous studies have demonstrated crucial role miRNAs in progression adenomas. Increasing evidence has indicated that circular RNAs (circRNAs) might mediate miRNA transcriptional activity, providing new insights to study NFPAs. To explore regulation activity circRNA–miRNA–mRNA axis tumorigenesis The function miR-145-5p was investigated...
With the rapid development of synthetic biology, various whole-cell biosensors have been designed as valuable biological devices for selective and sensitive detection toxic heavy metals in environmental water. However, most proposed are based on fluorescent bioluminescent signals invisible to naked eye. The visible pigment-based can address this issue. pbr operon from Klebsiella pneumoniae is selectively induced by bioavailable Pb(II). In present study, proviolacein biosynthetic gene cluster...