A5101925207- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- RNA regulation and disease
- Adipokines, Inflammation, and Metabolic Diseases
- Cellular Mechanics and Interactions
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Bone Metabolism and Diseases
- Cell death mechanisms and regulation
- Nerve injury and regeneration
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- Bone and Dental Protein Studies
Shanxi Agricultural University
2025
Xinxiang Medical University
2015-2024
Beijing University of Chinese Medicine
2024
Xi'an Institute of Optics and Precision Mechanics
2022
Nanyang Technological University
2009-2020
Xian Yang Central Hospital
2014
Institute of Molecular and Cell Biology
1998-2002
National University of Singapore
1998
Research Triangle Park Foundation
1996
National Institute of Environmental Health Sciences
1996
Abstract Melanoma is one of the most aggressive skin cancers worldwide. Although there has been much effort toward improving treatment options over past few years, remains an urgent need for effective therapy. Immunotherapy combined with chemotherapy shown great promise in clinical trials. Here, we studied cooperative effects small molecule drug pimozide, which a therapeutic effect melanoma, and RNA interference (RNAi) targeting PD-1, important immune checkpoint involved tumor escape. PD-1...
Porcine recombinant NK-lysin (prNK-lysin) has been shown to inhibit the proliferation and metastasis of hepatocellular carcinoma (HCC) cells in vitro. However, its effects on HCC vivo remain unclear. In this study, an allograft murine model using cell line Hepa1-6 was employed investigate anticancer prNK-lysin. Initially, vitro efficacy prNK-lysin evaluated cells, demonstrating that effectively inhibited both metastasis. These were mediated through induction oncosis suppression Fascin-1,...
Fibroblast growth factors (FGFs) and their high-affinity receptors contribute to autocrine paracrine stimulation in several human malignant tumors, including breast cancer. However, the mechanisms underlying carcinogenic actions of FGF18 remain unclear.The transcription level under hypoxic condition was detected with quantitative PCR (qPCR). A wound-healing assay performed assess role cell migration. clonogenicity used determine whether silencing affected clonogenicity. Western blotting...
Nowadays, although chemotherapy is an established therapy for breast cancer, the molecular mechanisms of resistance in cancer remain poorly understood. This study aims to explore effects endoplasmic reticulum stress on autophagy, apoptosis, and human cells by regulating PI3K/AKT/mTOR signaling pathway. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed detect cell viability six lines (MCF-7, ZR-75-30, T47D, MDA-MB-435s, MDA-MB-453, MDA-MB-231) treated with...
Melanoma is one of the most fatal and therapy-resistant types cancer; therefore, identifying novel therapeutic candidates to improve patient survival an ongoing effort. Previous studies have revealed that pimozide not sufficient treat melanoma; enhancing treatment necessary. Indoleamine 2, 3‑dioxygenase (IDO) immunosuppressive, intracellular rate-limiting enzyme, which contributes immune tolerance in various tumours, including melanoma, inhibition IDO may be considered a strategy when...
Abstract Colon cancer is a member of malignant tumors in the digestive system. Traditional treatment strategies are ineffective and improving colon an urgent need. Targeting programmed cell death‐1 (PD‐1) by monoclonal antibodies has shown some therapeutic effectiveness advantages. Additionally, Stat3 inhibitor nifuroxazide was employed to promote antitumor activity. Here, we hypothesized that combining with PD‐1 small interfering RNA carried attenuated Salmonella would exert synergistic...
c-Jun, a crucial component of the dimeric transcription factor activating protein 1 (AP-1), can regulate apoptosis induced by oxidative stress and has been implicated in neuronal differentiation, but mechanisms are largely unknown.We found that specific inhibition or stable transfection with cDNA encoding dominant-negative c-Jun sensitized SH-SY5Y neuroblastoma cells (TAM-67 cells) to nitric oxide (NO) donor sodium nitroprusside SIN-1.TAM-67 also became refractory nerve growth (NGF)-induced...
Melanoma is the most dangerous skin cancer due to its highly metastatic potential and resistance chemotherapy. Currently, there no effective treatment for melanoma once it progressed stage. Therefore, further study elucidate molecular mechanism underlying metastasis of cells urgently required improvement treatment. In present study, we found that diphthamide synthesis 3 (Dph3) involved in B16F10 murine by insertional mutagenesis. We demonstrated Dph3 disruption impairs migration cells. The...
Abstract Besides neural stem cells, some glial such as GFAP+ radial glia, and oligodendrocyte progenitor cells can produce neuronal cells. Attractively, NG2+ progenitors exhibit lineage plasticity, they rapidly proliferate differentiate in response to central nervous system (CNS) injuries. These attributes of make them a promising source neurons. However, the potential regeneration from CNS pathologies remains be investigated. In this study, we showed that antagonizing epidermal growth...
Summary Normal aging is characterized with a decline in hippocampal memory functions that associated changes long‐term potentiation ( LTP ) of the CA 3‐to‐ 1 synapse. Age‐related deficit dopaminergic system may contribute to impairment . Here we assessed how modulation by dopamine affected and it dependent on Ca 2+ source. In slices from adult mice, initial slope field potential showed strong , but aged mice was impaired. Dopamine did not affect slices, enhanced slices. The D1/D5 receptor...
Lumbar intervertebral disc herniation (LDH) is a common and frequently-occurring disease, which usually causes lumbar leg pain. Studies have shown that acupuncture can improve the symptoms of LDH patients. In present paper, we summarize progress researches on mechanisms underlying improvement in recent 10 years from 1) delaying intervertibral degeneration (by down-regulating expressions matrix metalloproteinase ［MMP］-3 MMP-4, up-regulating diosaccharides polyglycoprotein, inhibiting...