A5100763913- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Nerve injury and regeneration
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Mental Health Research Topics
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Robotic Locomotion and Control
- Botulinum Toxin and Related Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Context-Aware Activity Recognition Systems
- Axon Guidance and Neuronal Signaling
- IL-33, ST2, and ILC Pathways
- Spinal Dysraphism and Malformations
- Oral health in cancer treatment
- Signaling Pathways in Disease
- Pain Management and Treatment
- Single-cell and spatial transcriptomics
Nanchang University
2025
Beijing Friendship Hospital
2021-2025
Capital Medical University
2021-2025
First People's Hospital of Foshan
2025
Guangzhou Medical University
2021-2024
State Key Laboratory of Biotherapy
2024
Army Medical University
2018-2024
Xinqiao Hospital
2018-2024
Sichuan University
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Abstract The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly functionally diverse along their anterior–posterior superficial-deep axes. Here, we find that anterior BLA (aBLA) posterior (pBLA) innervate deep-layer calbindin1-negative (Calb1−) superficial-layer calbindin1-positive neurons (Calb1+) in vCA1, respectively. Photostimulation of pBLA–vCA1 inputs has an anxiolytic effect mice, promoting approach behaviours during conflict exploratory tasks. By contrast,...
Background: Patients with ulcerative colitis (UC) usually display cognitive impairments, such as memory loss, attention deficits, and declining executive functions, particularly during the active stage of disease. However, potential neurological mechanisms these symptoms remain unclear. Method: Forty-one patients mildly to moderately UC, well 42 matched healthy controls, were recruited for an examination using psychological scales, function tests resting-state functional magnetic resonance...
Abstract Aims A persistent cardiac T-cell response initiated by myocardial infarction is linked to subsequent adverse ventricular remodelling and progression of heart failure. No data exist on receptor (TCR) repertoire changes in combination with phenotypic characterization T cells ischaemic failing human hearts. Methods results Analysis TCR high-throughput sequencing revealed that compared control hearts, those hearts showed a clonally expanded but similar usage patterns TRBV-J...
Epicardial adipose tissue (EAT) acts as an active immune organ and plays a critical role in the pathogenesis of heart failure (HF). However, characteristics cells EAT HF patients have rarely been elucidated.To identify key EAT, integrated bioinformatics analysis was performed on public datasets. samples with paired subcutaneous (SAT), heart, peripheral blood from were collected validation experiments. T cell receptor (TCR) repertoire assessed by high-throughput sequencing. The phenotypic...
T regulatory (Treg) cells are essential for self-tolerance whereas they detrimental dampening the host anti-tumor immunity. How Treg adapt to environmental signals orchestrate their homeostasis and functions remains poorly understood. Here, we identified that transcription factor EB (TFEB) is induced by nutrition deprivation or interleukin (IL)-2 in CD4 + cells. The loss of TFEB leads reduced accumulation impaired function mouse models cancer autoimmune disease. intrinsically regulates genes...
This study explored the role of cathepsin B (CTSB) in optic nerve regeneration. Sprague–Dawley rats were utilized for crush and long-range injury model. Gene protein expression changes analyzed via reverse transcription quantitative polymerase chain reaction western blot. Primary cortical neurons BV2 cells cultured to assess CTSB’s effects on neuronal outgrowth microglial activity. Local CTSB administration degraded chondroitin sulfate proteoglycans (CSPGs), promoting axonal growth in-vivo....
Objective:This study aims to investigate the mechanism and potential effects of two exposures 100 dB sound pressure level（SPL） broadband white noise, with a 14-days interval, on myelin sheath cochlear auditory nerve in mice. The research provides experimental evidence for understanding pathophysiological processes noise-induced hearing loss hidden loss. Methods:Fifteen 6-week-old male C57BL/6J mice normal thresholds were randomly divided into three groups: control group（no noise exposure）,...
Objective: This study aimed to investigate the relationship between changes of serum indoxyl sulfate (IS) concentration, Klotho protein level, and cardiovascular complications in patients with chronic kidney disease (CKD) stage 3–5. Methods: A total 108 CKD 3–5 were selected. They divided into three groups: 3–4 group, 5 non-dialysis dialysis group. Echocardiography was used measure left ventricular diameter (LVD), interventricular septal thickness (IVS), posterior wall (LVPW), calcification....
Abstract The patterns of hippocampal neuronal loss and rewiring the dentate gyrus (DG) were studied in mouse model temporal lobe epilepsy at 2 months after pilocarpine‐induced status epilepticus (PISE). NeuN immunocytochemistry showed two damage, i.e., type 1 with partial pyramidal neurons CA3 area almost compete neurons. Anterograde tracing Phaseolus vulgaris leucoagglutinin (PHA‐L) demonstrated that, different rostrocaudal segments hippocampus, associational commissural connections DG...
Abstract Aims The present study aimed to compare temporal variability in the spontaneous fluctuations of activity and connectivity between amnestic MCI (aMCI) nonamnestic (naMCI), which enhances understanding their different pathophysiologies provides targets for individualized intervention. Methods Sixty‐five naMCI 48 aMCI subjects 75 healthy controls were recruited. A sliding window analysis was used evaluate dynamic amplitude low‐frequency (dALFF), regional homogeneity (dReHo), functional...
Abstract Background Subjective cognitive decline (SCD) is a putative Alzheimer’s disease (AD) precursor without objective neuropsychological deficits. The hippocampus plays an important role in function and emotional responses generally aberrant SCD. However, previous studies have mainly focused on static functional connectivity (sFC) by resting-state magnetic resonance imaging (fMRI) SCD individuals, it remains unclear whether hippocampal dynamic (dFC) changes exist those are associated...
Abstract Significant reduction in glutamate receptor 1 (GluR1)‐ and GluR2/3‐immunopositive neurons was demonstrated the hilus of dentate gyrus mice killed on days 1, 7 60 after pilocarpine‐induced status epilepticus (PISE). In addition, GluR1 GluR2/3 immunostaining strata oriens, radiatum lacunosum moleculare areas CA1–3 decreased drastically PISE. Neuronal loss observed above regions may account, at least part, for a decrease GluR immunoreactivity. By contrast, many GluR1‐immunopositive...
Abstract Early detection of patients with late-life depression (LLD) a high risk developing dementia contributes to early intervention. Odor identification (OI) dysfunction serves as marker for predicting dementia, but whether OI increases the in LLD remains unclear. The present study aimed explore interactive effect and on its underlying neuroimaging changes. One hundred fifty-seven 101 normal controls were recruited, data their OI, cognition, activity daily living (ADL), resting-state...
This study explores the efficacy of electroacupuncture (EA) in treating cerebral palsy (CP) Sprague-Dawley (SD) pups, specifically CP animal models, and its molecular mechanisms.
Abstract Besides neural stem cells, some glial such as GFAP+ radial glia, and oligodendrocyte progenitor cells can produce neuronal cells. Attractively, NG2+ progenitors exhibit lineage plasticity, they rapidly proliferate differentiate in response to central nervous system (CNS) injuries. These attributes of make them a promising source neurons. However, the potential regeneration from CNS pathologies remains be investigated. In this study, we showed that antagonizing epidermal growth...
Background: Odor identification dysfunction is an early predictor of the development Alzheimer's disease (AD), but neuropsychiatric symptoms (NPS), which are common in AD and mild cognitive impairment (MCI), also associated with odor dysfunction. Whether NPS affect specificity using to predict decline MCI remains unclear. Methods: Patients (233 45 AD) healthy controls (HCs) underwent assessments (Sniffin' Sticks), (Neuropsychiatric Inventory-12), function (global cognition, memory, language,...
Abstract Background Slowed information processing speed (IPS) is the core contributor to cognitive impairment in patients with late-life depression (LLD). The hippocampus an important link between and dementia, it may be involved IPS slowing LLD. However, relationship a slowed dynamic activity connectivity of hippocampal subregions LLD remains unclear. Methods One hundred thirty-four 89 healthy controls were recruited. Sliding-window analysis was used assess whole-brain functional (dFC),...