A5025104684- Soft Robotics and Applications
- Aluminum Alloy Microstructure Properties
- Microstructure and mechanical properties
- Genetic Neurodegenerative Diseases
- Natural Language Processing Techniques
- Topic Modeling
- Additive Manufacturing Materials and Processes
- Robot Manipulation and Learning
- Aluminum Alloys Composites Properties
- Mitochondrial Function and Pathology
- Functional Brain Connectivity Studies
- Metallurgy and Material Forming
- Titanium Alloys Microstructure and Properties
- High Entropy Alloys Studies
- Advanced Sensor and Energy Harvesting Materials
- Intermetallics and Advanced Alloy Properties
- Shape Memory Alloy Transformations
- EEG and Brain-Computer Interfaces
- Magnetic and transport properties of perovskites and related materials
- Teleoperation and Haptic Systems
- Neurological disorders and treatments
- Olfactory and Sensory Function Studies
- Advanced Neuroimaging Techniques and Applications
- Micro and Nano Robotics
- Advanced Chemical Sensor Technologies
Tongji University
2016-2025
Xinxiang Medical University
2025
Beijing Jiaotong University
2023-2024
Johns Hopkins Medicine
2008-2024
Johns Hopkins University
2009-2024
Guangzhou Medical University
2017-2024
Shaanxi University of Science and Technology
2022-2024
NARI Group (China)
2024
Hong Kong Polytechnic University
2024
First People's Hospital of Jingzhou
2024
Huntington's disease (HD) is a fatal neurodegenerative characterized by abnormal motor coordination, cognitive decline and psychiatric disorders. This caused an expanded CAG trinucleotide repeat in the gene encoding protein huntingtin. Reduced levels of brain-derived neurotrophic factor (BDNF) brain, which results from transcriptional inhibition axonal transport deficits mediated mutant huntingtin, have been suggested as critical factors underlying selective neurodegeneration both HD...
The peroxisome-proliferator-activated receptor gamma coactivator 1 α (PGC1α) has been implicated in the pathogenesis of several neurodegenerative disorders, including Huntington9s disease (HD). Recent data demonstrating white matter abnormalities PGC1α knock-out (KO) mice prompted us to examine role CNS myelination and its relevance HD pathogenesis. We found deficient postnatal striatum KO mice, accompanied by a decrease myelin basic protein (MBP). In addition, brain cholesterol, precursors,...
Huntington's disease (HD) is a devastating genetic neurodegenerative caused by CAG trinucleotide expansion in the exon-1 region of huntingtin gene. Currently, no cure available. It becoming increasingly apparent that mutant Huntingtin (HTT) impairs metabolic homeostasis and causes transcriptional dysregulation. The peroxisome proliferator-activated receptor gamma (PPAR-γ) factor plays key role regulating genes involved energy metabolism; recent studies demonstrated PPAR-γ activation...
Despite the apparent usefulness of efficient mental workload assessment in various real-world situations, underlying neural mechanism remains largely unknown, and studies are limited to well-controlled cognitive tasks using a 2D computer screen. In this paper, we investigated functional brain network alterations simulated flight experiment with three levels compared reorganization pattern between screen (2D) virtual reality (3D) interfaces. We constructed multiband networks...
Maintaining sustained attention during a prolonged cognitive task often comes at cost: high levels of mental fatigue. Heuristically, fatigue refers to feeling tiredness or exhaustion, and disengagement from the hand; it manifests as impaired behavioral performance. In order effectively reduce undesirable yet preventable consequences in many real-world workspaces, better understanding underlying neural mechanisms is needed, continuous efforts have been devoted this topic. comparison with...
There is a surge of research interest in the field "continuum robotics." Robots created under this paradigm offer many advantages and represent unique features terms flexibility, dexterity, safety, weight reduction. This paper introduces novel continuum manipulator that integrates multiple layers compliant planar springs-a structure provides several notable over existing designs. First, it possesses precise linear large-displacement motion. In context, we utilize output motion each layer...
White matter abnormalities have been reported in premanifest Huntington's disease (HD) subjects before overt striatal neuronal loss, but whether the white changes represent a necessary step towards further pathology and underlying mechanism of these remains unknown. Here, we characterized novel knock-in mouse model that expresses HD gene homolog (Hdh) with extended CAG repeat- HdhQ250, which was derived from selective breeding HdhQ150 mice. HdhQ250 mice manifest an accelerated robust...
Soft pneumatic actuators (SPAs), as novel types of motion drivers for robotic devices, excel in many applications, such rehabilitation and biomimicry, which demand compliance softness. To further expand their scope utilization, the SPAs should be customizable to meet distinctive requirements different applications. This article proposes a perspective on SPA working mechanism based stiffness distribution then presents versatile method called customization patterning (SCP) body layout attempt...
Continuum manipulators are a rapidly emerging class of robots. However, due to the complexity their mathematical models and modeling inaccuracies, development effective control systems is particularly challenging task. This paper presents first attempt on kinematic continuum using fuzzy-model-based approach. A fuzzy controller proposed for autonomous execution end-effector trajectory tracking tasks manipulator. Particularly, membership functions employed combine linearized state-space...
Huntington's disease (HD) is caused by an expansion of the trinucleotide poly (CAG) tract located in exon 1 huntingtin (Htt) gene leading to progressive neurodegeneration selected brain regions, and associated functional impairments motor, cognitive, psychiatric domains. Since discovery mutation that causes disease, mouse models have been developed different strategies. Recently, a new model, zQ175 knock-in (KI) line, was attempt Htt context causing phenotype more closely mimics HD humans....
Due to the increasing fatal traffic accidents, there are strong desire for more effective and convenient techniques driving fatigue detection.Here, we propose a unified framework -E-Key simultaneously perform personal identification (PI) detection using convolutional attention neural network (CNN-Attention).The performance was assessed EEG data collected through wearable dry-sensor system from 31 healthy subjects undergoing 90-min simulated task.In comparison with three widely-used...
Stimuli-responsive micro/nanostructures that exhibit not only programmable but also reprogrammable actuation behaviors are highly desirable for various advanced engineering applications (e.g., anticounterfeiting, information encoding, dynamic imaging and display, microrobotics, etc.) yet to be realized with state-of-the-art technologies. Here we report a concept corresponding experimental technique core–shell magnetic micropillars enabling simultaneously actuations using simple field. The...