A5029774267- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- T-cell and Retrovirus Studies
- Cancer Cells and Metastasis
- Wound Healing and Treatments
- Sarcoma Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Sulfur-Based Synthesis Techniques
- Structural Behavior of Reinforced Concrete
- Blood properties and coagulation
- Immune cells in cancer
- Click Chemistry and Applications
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Protein Degradation and Inhibitors
- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- TGF-β signaling in diseases
Albert Einstein College of Medicine
2015-2025
Henan Normal University
2023-2025
Shanghai Ocean University
2024
Xinxiang Medical University
2014-2024
First Affiliated Hospital of Xinxiang Medical University
2016-2024
Changsha University of Science and Technology
2024
Tianjin Medical University
2014-2023
Qufu Normal University
2023
National Health and Family Planning Commission
2023
Jiangsu Normal University
2020-2022
Abstract WNT/β-catenin signalling is crucial for intestinal homoeostasis. The epithelium and stroma are the major source of WNT ligands but their origin role in stem cell (ISC) epithelial repair remains unknown. Macrophages a constituent stroma. Here, we analyse macrophage-derived mice by inhibiting release using macrophage-restricted ablation Porcupine, gene essential synthesis. Such Porcn -depleted have normal morphology hypersensitive to radiation injury intestine compared with wild-type...
Colorectal cancer (CRC) is the third leading cause of cancer‑associated mortality, and a major health problem. Collagen type I α 1 (COL1A1) component collagen I. Recently, it was reported to be overexpressed in variety tumor tissues cells. However, function COL1A1 CRC remains unclear. Herein, present study demonstrated that upregulated paired lymph node tissues. Transwell assays showed promoted cell migration vitro. Moreover, revealed levels were correlated with those WNT/planar polarity...
Abstract The bone marrow microenvironment influences malignant hematopoiesis, but how it promotes leukemogenesis has not been elucidated. In addition, the role of stroma in regulating clinical responses to DNA methyltransferase inhibitors (DNMTi) is also poorly understood. this study, we conducted a methylome analysis marrow–derived stromal cells from myelodysplastic syndrome (MDS) patients and observed widespread aberrant cytosine hypermethylation occurring preferentially outside CpG...
Abstract The BCL2-inhibitor, Venetoclax (VEN), has shown significant anti-leukemic efficacy in combination with the DNMT-inhibitor, Azacytidine (AZA). To explore mechanisms underlying selective sensitivity of mutant leukemia cells to VEN and AZA, we used cell-based isogenic models containing a common leukemia-associated mutation epigenetic regulator ASXL1 . KBM5 CRISPR/Cas9-mediated correction G710X showed reduced leukemic growth, increased myeloid differentiation, decreased HOXA BCL2 gene...
Abstract NF-κB activates the primary inflammatory response pathway responsible for methicillin-resistant Staphylococcus aureus (MRSA)-induced lung inflammation and injury. Here, we report that Forkhead box transcription factor FOXN3 ameliorates MRSA-induced pulmonary injury by inactivating signaling. competes with IκBα binding to heterogeneous ribonucleoprotein-U (hnRNPU), thereby blocking β-TrCP-mediated degradation leading inactivation. is directly phosphorylated p38 at S83 S85 residues,...
ABSTRACT Tumor necrosis factor alpha (TNF) plays a critical role in the control of Mycobacterium tuberculosis , part by augmenting T cell responses through promoting macrophage phagolysosomal fusion (thereby optimizing CD4 + immunity enhancing antigen presentation) and apoptosis (a process that can lead to cross-priming CD8 cells). M. evade antituberculosis (anti-TB) inhibiting host TNF production via expression specific mycobacterial components. We hypothesized mutants with an increased...
Abstract Osteosarcoma (OS), the most common primary cancer of bone, exhibits a high propensity for local invasion and distant metastasis. This study sought to elucidate role S phase kinase-associated protein (Skp2) in osteosarcoma metastasis explore flavokawain A (FKA), natural chalcone from kava extract, as potential Skp2 targeting agent preventing progression. was found be overexpressed multiple cell lines, including 5 standard 8 patient-derived lines. Patients whose tumors expressed...
Colorectal cancer (CRC) treatment primarily relies on chemotherapy along with surgery, radiotherapy and, more recently, targeted therapy at the late stages. However, chemotherapeutic drugs have high cytotoxicity, and similarity between effects of these cancerous healthy cells limits their wider use in clinical settings. Targeted monoclonal antibody may compensate for this deficiency. Epidermal growth factor receptor (EGFR)‑targeted a positive effect CRC intact KRAS proto-oncogene GTPase...
The current study reveals that in chronic TB, the B cell-deficient μMT strain, relative to wild-type (WT) C57BL/6 mice, displays lungs lower levels of inflammation are associated with decreased CD4 + T cell proliferation, diminished Th1 response, and enhanced interleukin (IL)-10. latter result raises possibility cells may restrict lung expression IL-10 TB. These observations recapitulated WT mice depleted for using anti-CD20 antibodies. receptor (IL-10R) blockade reverses phenotypes...
Abstract Macrophages sense changes in the extracellular matrix environment through integrins and play a central role regulation of reparative response after myocardial infarction. Here we show that macrophage integrin α5 protects infarcted heart from adverse remodeling protective actions are associated with acquisition an angiogenic phenotype. We demonstrate myeloid cell- macrophage-specific knockout mice have accentuated post-infarction remodeling, accompanied by reduced angiogenesis...
Aeromonas veronii, hydrophila, Plesiomonas shigelloides, and Citrobacter freundii were opportunistic pathogen widely distributed in water environment fish population, causing diseases under stressful conditions. In this study, bacteria isolated from diseased common carp Cyprinus carpio with symptoms of hemorrhage on body surface, abdominal distention, flatulence the intestine. According to results biochemical characteristics, 16S rRNA sequencing analyses, isolates identified as A. P. C....
Monocytes in the central nervous system (CNS) play a pivotal role surveillance and homeostasis, can exacerbate pathogenic processes during injury, infection, or inflammation. CD14+CD16+ monocytes exhibit diverse functions contribute to neuroinflammatory diseases, including HIV-associated neurocognitive impairment (HIV-NCI). Analysis of human matured vitro by single-cell RNA sequencing identified heterogenous population nine clusters. Ingenuity pathway analysis differentially expressed genes...
Identifying effective therapies targeting multi-protein complexes that lack catalytic sites or cofactor pockets remains a long-standing challenge. The proto-oncogene, ubiquitin E3 ligase SCFSkp2, is one such target. SCFSkp2 promotes the proteasomal degradation of cyclin-dependent kinase inhibitor p27, which controls cell cycle progression. Targeted knockout Rb1/Trp53 causes metastatic prostate cancer in mice; additional Skp2 completely blocks tumorigenesis. We compared gene-edited mice...
Aeromonas veronii, hydrophila, Plesiomonas shigelloides, and Citrobacter freundii are opportunistic pathogens that widely distributed in aquatic environments fish populations, causing diseases under stressful conditions. In this study, bacteria were isolated from a group of diseased common carp, Cyprinus carpio, with symptoms hemorrhaging along the body surface, abdominal distention, flatulence intestine. According to results biochemical characteristics 16S rRNA sequencing analyses, isolates...
Adult T-cell leukemia/lymphoma (ATLL), an aggressive malignancy associated with human leukemia virus type 1, presents significant therapeutic challenges due to high relapse rates and resistance therapy. Here, we present the first reported case of ATLL treated talimogene laherparepvec (T-VEC), oncolytic viral immunotherapy approved for unresectable melanoma. The patient, who had experienced disease progression despite multiple lines chemotherapy, radiotherapy, immunotherapy, targeted therapy,...
Fibroblast growth factors (FGFs) and their high-affinity receptors contribute to autocrine paracrine stimulation in several human malignant tumors, including breast cancer. However, the mechanisms underlying carcinogenic actions of FGF18 remain unclear.The transcription level under hypoxic condition was detected with quantitative PCR (qPCR). A wound-healing assay performed assess role cell migration. clonogenicity used determine whether silencing affected clonogenicity. Western blotting...