A5039249293- Tuberculosis Research and Epidemiology
- Probiotics and Fermented Foods
- Mycobacterium research and diagnosis
- Salmonella and Campylobacter epidemiology
- Viral Infections and Vectors
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Viral Infections and Outbreaks Research
- Adipokines, Inflammation, and Metabolic Diseases
- Circadian rhythm and melatonin
- Antimicrobial Peptides and Activities
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease and Transplantation
- Biopolymer Synthesis and Applications
- Curcumin's Biomedical Applications
- Nitric Oxide and Endothelin Effects
- Iron Metabolism and Disorders
- Bacterial Infections and Vaccines
- NF-κB Signaling Pathways
- Traditional Chinese Medicine Analysis
- Phytochemical compounds biological activities
- Vitamin C and Antioxidants Research
Louisiana State University Health Sciences Center Shreveport
2023-2025
Louisiana State University in Shreveport
2024
Rutgers New Jersey Medical School
2023
Rutgers, The State University of New Jersey
2023
Albert Einstein College of Medicine
2014-2018
Panjab University
2006-2013
Czech Academy of Sciences, Institute of Microbiology
2013
There is an urgent need for monoclonal antibody (mAb) therapies that broadly protect against Ebola virus and other filoviruses. The conserved, essential interaction between the filovirus glycoprotein, GP, its entry receptor Niemann-Pick C1 (NPC1) provides attractive target such mAbs but shielded by multiple mechanisms, including physical sequestration in late endosomes. Here, we describe a bispecific-antibody strategy to this interaction, which specific NPC1 or GP receptor-binding site are...
Summary The present study is aimed at investigating the effect of curcumin (CMN) in salvaging endotoxin-induced hepatic dysfunction and oxidative stress liver rodents. Hepatotoxicity was induced by administering lipopolysaccharide (LPS) a single dose 1 mg/kg intraperitoneally to animals, which were being treated with CMN daily for 7 days. Liver enzymes serum alanine aminotransferase (ALT), aspartate (AST) alkaline phosphatase (ALP), total bilirubin protein estimated serum. Oxidative tissue...
Induction of nuclear factor kappa B (NF-κB)-mediated gene expression has been implicated in the pathogenesis alcoholic liver disease through enhanced production reactive oxygen species and pro-inflammatory mediators. The present study was carried out to investigate role catechin as a chain breaking inhibitor against experimental injury. Rats were administered 35% v/v ethanol orally at dose 10 g/Kg/day for two weeks, followed by 14 weeks. Catechin (50 mg/Kg) co-supplemented after 4 weeks...
In view of the increasing interest in bioecological and nutritional control diseases, use probiotics alone or combination with prebiotics (synbiotics) appears as a therapeutic option for various diseases. this study, an attempt was made to explore protective potential Lactobacillus acidophilus probiotic, inulin prebiotic both L. synbiotic against Salmonella-induced liver damage murine model. The supplementation resulted decreased bacterial translocation mice challenged Salmonella typhimurium...
The current study reveals that in chronic TB, the B cell-deficient μMT strain, relative to wild-type (WT) C57BL/6 mice, displays lungs lower levels of inflammation are associated with decreased CD4 + T cell proliferation, diminished Th1 response, and enhanced interleukin (IL)-10. latter result raises possibility cells may restrict lung expression IL-10 TB. These observations recapitulated WT mice depleted for using anti-CD20 antibodies. receptor (IL-10R) blockade reverses phenotypes...
Objective Diffuse central nervous system manifestations, referred to as neuropsychiatric lupus (NPSLE), are observed in 20–40% of patients and involve complex mechanisms that have not yet been adequately elucidated. In murine NPSLE models, choroid plexus (ChP)-infiltrating T cells fully evaluated drivers disease. Method Droplet-based single-cell transcriptomic analysis (single-cell RNA sequencing) immune T-cell receptor profiling were performed on ChP tissue from MRL/lpr mice, an mouse...
Abstract Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. The lipid metabolic state of macrophages influences their function polarization, which is crucial the resolution contribution synthesis proinflammatory macrophage responses well understood. However, how regulates proresolving needs be better Lipin-1 a phosphatidic acid phosphatase with transcriptional coregulatory activity that metabolism. We previously demonstrated lipin-1 supports...
Vitamin E (-Tocopherol [-Toc]) is the primary membrane bound, lipid-soluble, chain-breaking antioxidant that has been reported to protect against lipid peroxidation-induced tissue damage.Therefore, present study was designed investigate protection afforded by α-Tocopherol (vitamin E), if any, on LPS-induced liver injury in Wistar rats and underlying mechanism of protection.Bacterial endotoxin (10 mg/Kg body weight-prestandardized dose) injected intraperitoneally animals were sacrificed 8 h...
In view of the emergence multidrug-resistant Salmonella strains, there is a need for therapeutic alternatives. To reduce dose antibiotic required in order to decrease associated side effects, present study was aimed at evaluating synergism between cryptdin 2 (a Paneth cell antimicrobial peptide) and ampicillin (Amp) against enterica serovar Typhimurium. The synergy evaluated terms fractional bactericidal concentration (FBC) index, time-kill assay results (in vitro), macrophage functions,...
Activation of NF-κB has been reported to play a key role in causing endotoxin-induced hepatic damage through enhanced production reactive oxygen species and pro-inflammatory mediators. In this context, the potential polyphenolic phytochemicals preventing liver remains unclear. Here, we demonstrate that catechin quercetin have down-regulate initial signalling molecule which may further inhibit downstream cascade including TNF-α NO. These results were confirmed using N-nitro-L-arginine methyl...
Bordetella spp. are respiratory pathogens equipped with immune evasion mechanisms. We previously characterized a bronchiseptica mutant (RB50ΔbtrS) that fails to suppress host responses, leading rapid clearance and long-lasting immunity against reinfection. This work revealed eosinophils as an exclusive requirement for RB50ΔbtrS clearance. also show promotes eosinophil-mediated B/T cell recruitment inducible bronchus-associated lymphoid tissue (iBALT) formation, being present throughout iBALT...
Mycobacterium tuberculosis remains a threat to global health, and more efficacious vaccine is needed prevent disease caused by M. . We previously reported that the mycobacterial ribosome major target of CD4 + T cells in mice immunized with genetically modified smegmatis strain (IKEPLUS) but not bovis BCG.
Glucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, metabolic functions. Inflammation tissue promotes systemic dysfunction; however, molecular mechanisms underlying role adipocyte in regulating genes associated with inflammation poorly understood. We performed vivo studies using adipocyte-specific knockout mice...
Bacterial endotoxin or lipopolysaccharide causes extensive damage to various organs including the liver. This is due an increased production of tumor necrosis factor α induced- reactive intermediates. These intermediates are known cause a variety cellular biomolecules leading oxidative stress. In present study, role pineal hormone melatonin was evaluated as antioxidant against hepatotoxicity using Wistar rats. injected (i.v) and animals were sacrificed 8h post-challenge. Endotoxemia...
Background & Objectives: Shigellosis is endemic throughout the world causing great deal of morbidity and mortality.Emergence antibiotic resistance lack vaccine against Shigella, necessitates exploitation alternative strategies to combat Shigella infection.The present study was undertaken evaluate effect cell free supernatant (CFS) from Lactobacillus plantarum (L.plantarum) flexneri (S. flexneri). Methods:The CFS S. studied in terms agar well diffusion assay, time kill adherence inhibition...
Abstract Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. The lipid metabolic state of macrophages influences their function, but a deeper understanding how metabolism is regulated in pro-resolving macrophage responses needed. Lipin-1 phosphatidic acid phosphatase with transcriptional coregulatory activity (TC) that regulates metabolism. We previously demonstrated lipin-1 supports responses, here, myeloid-associated required for inflammation...