A5069828627- Lipid metabolism and biosynthesis
- Phagocytosis and Immune Regulation
- Sphingolipid Metabolism and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lipid Membrane Structure and Behavior
- Fatty Acid Research and Health
- Peroxisome Proliferator-Activated Receptors
Louisiana State University Health Sciences Center Shreveport
2020-2025
Abstract Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. The lipid metabolic state of macrophages influences their function polarization, which is crucial the resolution contribution synthesis proinflammatory macrophage responses well understood. However, how regulates proresolving needs be better Lipin-1 a phosphatidic acid phosphatase with transcriptional coregulatory activity that metabolism. We previously demonstrated lipin-1 supports...
Phospholipases are a family of lipid altering enzymes that can either reduce or increase bioactive levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote g-coupled protein activity, and modulate membrane fluidity mediate cellular function. the they produce important regulators on immune cell dictating both pro-inflammatory pro-resolving activity. During atherosclerosis, activities govern atherosclerosis progression regression respectively. This review...
Abstract Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. The lipid metabolic state of macrophages influences their function, but a deeper understanding how metabolism is regulated in pro-resolving macrophage responses needed. Lipin-1 phosphatidic acid phosphatase with transcriptional coregulatory activity (TC) that regulates metabolism. We previously demonstrated lipin-1 supports responses, here, myeloid-associated required for inflammation...
Abstract Free fatty acid accumulation in macrophages alters cellular metabolism, leading to failed inflammation resolution that contributes cardiometabolic pathologies such as atherosclerotic cardiovascular disease. acids are either broken down by β-oxidation, stored glycerolipids, or incorporated into sphingolipids (e.g., ceramides). Ceramide synthesis inhibits several pro-resolving macrophage functions, β-oxidation and efferocytosis, needed for resolution. The regulatory signals control...
Abstract Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. Unresolved inflammation contributes the pathophysiology of cardiometabolic diseases. The lipid metabolic state macrophages influences their function. Lipid synthesis proinflammatory responses, while beta-oxidation is required for pro-resolving macrophage However, how metabolism regulated activation not well understood. Lipin-1 a phosphatidic acid phosphatase with transcriptional...