A5067154889- Effects and risks of endocrine disrupting chemicals
- Urban Heat Island Mitigation
- Urban Green Space and Health
- Fibroblast Growth Factor Research
- Immune cells in cancer
- Toxic Organic Pollutants Impact
- Cytokine Signaling Pathways and Interactions
- Land Use and Ecosystem Services
- Birth, Development, and Health
- Per- and polyfluoroalkyl substances research
- Chemokine receptors and signaling
- Flood Risk Assessment and Management
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Remote Sensing and Land Use
- MicroRNA in disease regulation
- Climate Change and Health Impacts
- Pesticide Residue Analysis and Safety
- Air Quality and Health Impacts
- Analytical chemistry methods development
- Health, Environment, Cognitive Aging
- Noise Effects and Management
- Protease and Inhibitor Mechanisms
- Cancer-related gene regulation
Nanjing University
2020-2025
Fudan University
2022-2025
Albert Einstein College of Medicine
2004-2025
Southwest Forestry University
2024
National Health and Family Planning Commission
2022-2024
Hong Kong Baptist University
2016-2023
NYU Langone Health
2019-2023
Shaoguan Railway Hospital
2018-2023
Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application
2021-2023
Pacific Northwest National Laboratory
2023
Background The stromal microenvironment and particularly the macrophage component of primary tumors influence their malignant potential. However, at metastatic site role these cells mechanism actions for establishment growth metastases remain largely unknown. Methodology/Principal Findings Using animal models breast cancer metastasis, we show that a population host macrophages displaying distinct phenotype is recruited to extravasating pulmonary regardless species origin. Ablation this...
Pulmonary metastasis of breast cancer cells is promoted by a distinct population macrophages, metastasis-associated macrophages (MAMs), which originate from inflammatory monocytes (IMs) recruited the CC-chemokine ligand 2 (CCL2). We demonstrate here that, through activation CCL2 receptor CCR2, MAMs secrete another chemokine CCL3. Genetic deletion CCL3 or its CCR1 in reduces number lung foci, as well accumulated tumor-challenged mice. Adoptive transfer WT IMs increases reduced foci Ccl3...
Abstract WNT/β-catenin signalling is crucial for intestinal homoeostasis. The epithelium and stroma are the major source of WNT ligands but their origin role in stem cell (ISC) epithelial repair remains unknown. Macrophages a constituent stroma. Here, we analyse macrophage-derived mice by inhibiting release using macrophage-restricted ablation Porcupine, gene essential synthesis. Such Porcn -depleted have normal morphology hypersensitive to radiation injury intestine compared with wild-type...
Although the link between inflammation and cancer initiation is well established, its role in metastatic diseases, primary cause of deaths, has been poorly explored. Our previous studies identified a population metastasis-associated macrophages (MAMs) recruited to lung that promote tumor cell seeding growth. Here we show FMS-like tyrosine kinase 1 (Flt1, also known as VEGFR1) labels subset human breast cancers are significantly enriched sites. In mouse models pulmonary metastasis, MAMs...
The application of metabolomics in translational research suffers from several technological bottlenecks, such as data reproducibility issues and the lack standardization sample profiling procedures. Here, we report an automated high-throughput metabolite array technology that can rapidly quantitatively determine 324 metabolites including fatty acids, amino organic carbohydrates, bile acids. Metabolite identification quantification is achieved using Targeted Metabolome Batch Quantification...
Abstract Oncogenic targets acting in both tumor cells and stromal may offer special therapeutic appeal. Interrogation of the Oncomine database revealed that 52 53 human breast carcinomas showed substantial upregulation WNT family ligand WNT7B. Immunolabeling mammary carcinoma WNT7B immunoreactivity was associated with tumor-associated macrophages. In MMTV-PymT mouse model carcinoma, we found progression relied upon produced by myeloid microenvironment. Wnt7b deletion reduced mass volume...
Benzophenones (BPs), parabens, and triclosan (TCS) are widely used in personal care products may be neurotoxic to children, but limited studies have estimated the associations between exposure these potential endocrine disrupting chemicals during pregnancy child neurocognitive development. Our aim was evaluate relationships of prenatal BPs, parabens TCS with development at age 2. From 2014 2015, 478 mother-child pairs from a longitudinal cohort China were included present study. We...
Phthalates are a family of endocrine disruptors with short elimination half-lives in the human body. To date, few epidemiological studies have examined repeated measures maternal urinary phthalates and combined effects prenatal exposure to multiple on children's neurocognitive development.We aimed investigate association between development at 2 years age phthalate exposure, as assessed by measurements during pregnancy, further examine co-exposure using cumulative risk assessment.Within...
Abstract The significant reduction in human activities during COVID‐19 lockdown is anticipated to substantially influence urban climates, especially heat islands (UHIs). However, the UHI variations periods remain be quantified. Based on MODIS daily land surface temperature and in‐situ air observations, we reveal a substantial decline both canopy UHIs over 300‐plus megacities China compared with reference periods. intensity (UHII) reduced by 0.25 (one S.D. = 0.22) K daytime 0.23 (0.20) at...
Epidemiological data on the effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) infant neurodevelopment trajectories are far from being sufficiently addressed. In this study, 1285 mother-child pairs were recruited during 2016-2017. A high-performance liquid chromatography-triple quadrupole mass spectrometer was used to measure 16 PFAS levels in cord serum. Ages Stages Questionnaires examine children's at 2, 6, 12, 24 months age. Group-based trajectory models applied derive...
Abstract A comprehensive comparison of the trends and drivers global surface canopy urban heat islands (termed I s c trends, respectively) is critical for better designing mitigation strategies. However, such a remains largely absent. Using spatially continuous land temperatures air (2003–2020), here we find that magnitude mean trend (0.19 ± 0.006°C/decade, SE) 5,643 cities worldwide nearly six‐times corresponding (0.03 0.002°C/decade) during day, while former (0.06 0.004°C/decade) double...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination-repair (HR-repair) proteins 20%-25% of cases. Defects HR impart specific vulnerability to poly ADP ribose polymerase inhibitors and platinum-containing chemotherapy tumor cells. However, not all patients who receive these therapies respond, many initially respond ultimately develop resistance. Inactivation the pathway associated with overexpression theta (Polθ, or POLQ)....
Bisphenol S (BPS) and bisphenol F (BPF) are increasingly used in manufacturing consumer products to replace the use of A (BPA), but exposure data limited, particularly among pregnant women. Here, we measured BPA, BPS, BPF levels urine samples, collected from 941 women over three trimesters. We examined correlations, coexposure patterns, variability, predictors bisphenols using Spearman's correlation coefficient, percentile analysis, intraclass linear mixed models, respectively. assessed...