A5101717324- Bariatric Surgery and Outcomes
- Body Contouring and Surgery
- Pharmaceutical and Antibiotic Environmental Impacts
- DNA Repair Mechanisms
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- PARP inhibition in cancer therapy
- Diet and metabolism studies
- Antimicrobial Peptides and Activities
- Hepatocellular Carcinoma Treatment and Prognosis
- interferon and immune responses
- Mast cells and histamine
- Economic and Financial Impacts of Cancer
- Hepatitis C virus research
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- Genomics, phytochemicals, and oxidative stress
- Multiple and Secondary Primary Cancers
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Air Quality Monitoring and Forecasting
- Intestinal and Peritoneal Adhesions
- Vehicle emissions and performance
- Cancer Immunotherapy and Biomarkers
University of California, Davis
2024
NYU Langone Health
2020-2024
Rutgers, The State University of New Jersey
2021-2022
Rutgers New Jersey Medical School
2021
New York University
2021
Villanova University
2020
Loma Linda University
2018
University of Toronto
2013-2017
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination-repair (HR-repair) proteins 20%-25% of cases. Defects HR impart specific vulnerability to poly ADP ribose polymerase inhibitors and platinum-containing chemotherapy tumor cells. However, not all patients who receive these therapies respond, many initially respond ultimately develop resistance. Inactivation the pathway associated with overexpression theta (Polθ, or POLQ)....
Innate immunity during acute infection plays a critical role in the disease severity of severe respiratory syndrome (SARS) and Middle East (MERS), is likely to contribute COVID-19 outcomes. Defensins are highly abundant innate immune factors neutrophils epithelial cells, including intestinal Paneth exhibit antimicrobial immune-modulatory activities. In this study, we investigated effects human α- β-defensins RC101, θ-defensin analog, on SARS-CoV-2 infection. We found that neutrophil peptides...
Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis, propensity for early metastasis and resistance to chemotherapy. Little known about the mechanisms that drive innate therapeutic in pancreatic cancer. The ataxia-telangiectasia group D-associated gene (ATDC) overexpressed cancer promotes tumor growth metastasis. Our study reveals increased ATDC levels protect cells from reactive oxygen species (ROS) via stabilization of nuclear factor erythroid 2-related 2...
OBJECTIVE The relationship between hospital antibiotic use and resistance is poorly understood. We evaluated the association utilization in academic community hospitals Ontario, Canada. METHODS conducted a multicenter observational ecological study of 37 2014. Hospital purchasing data were used as an indicator use, whereas extracted from indexes resistance. Multivariate regression was performed, with susceptibility primary outcome, consumption main predictor, additional covariates interest...
In this study, we used zinc finger nuclease-mediated knockout of the aryl hydrocarbon receptor (AHR) or AHR nuclear translocator (ARNT) in MCF7 and MDA-MB-231 human breast cancer cells to investigate cross talk among AHR, ARNT, estrogen α (ERα). Knockout ARNT prevented 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-dependent induction all target genes examined. also significantly reduced basal cytochrome P4501B1 (CYP1B1) expression levels, which were restored with overexpression either protein...
Antimicrobial resistance (AMR) causes millions of illnesses every year, threatening the success lifesaving antibiotic therapy and, thus, public health. To examine rise and spread antimicrobial around world, our study performs a multivariate statistical analysis gene data from eight different countries: US, UK, China, Brazil, Mexico, Canada, Australia, South Africa. Multi-dimensional points were projected onto two-dimensional plane using principal component organized into dendrogram utilizing...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination (HR) repair genes up to 25% of cases. Defects HR impart tumor cells specific vulnerability poly-ADP ribose polymerase inhibitors and platinum-based chemotherapy. However, not all patients respond, some who initially respond develop resistance progress. Thus, new therapies are effective against HR-deficient PDAC needed. Here, we show inactivation the pathway...