A5100424672- Cancer Research and Treatments
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Thyroid Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Genomics, phytochemicals, and oxidative stress
- Genomic variations and chromosomal abnormalities
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- 3D Printing in Biomedical Research
- Receptor Mechanisms and Signaling
- Wnt/β-catenin signaling in development and cancer
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
China Medical University
2015-2025
First Hospital of Jilin University
2015-2023
Jilin University
2015-2023
NYU Langone Health
2023
Sheng Jing Hospital
2022
New York University
2021
Zhengzhou University
1999-2019
Shandong Provincial Hospital
2019
Second Affiliated Hospital of Zhengzhou University
2017
First Affiliated Hospital of Henan University
2017
Oxidative damage and inflammation are closely associated with the pathogenesis of acute lung injury (ALI). Thus, we explored protective effect isovitexin (IV), a glycosylflavonoid, in context ALI. To accomplish this, created vitro vivo models by respectively exposing macrophages to lipopolysaccharide (LPS) using LPS induce ALI mice. In vitro, our results showed that IV treatment reduced LPS-induced pro-inflammatory cytokine secretion, iNOS COX-2 expression decreased generation ROS....
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination-repair (HR-repair) proteins 20%-25% of cases. Defects HR impart specific vulnerability to poly ADP ribose polymerase inhibitors and platinum-containing chemotherapy tumor cells. However, not all patients who receive these therapies respond, many initially respond ultimately develop resistance. Inactivation the pathway associated with overexpression theta (Polθ, or POLQ)....
Ranking as the fourth commonest cancer, esophageal squamous cell carcinoma (ESCC) represents one of leading causes cancer death in China. One main reasons for low survival rate is that neoplasms esophagus are not detected until they have invaded into surrounding tissues or spread throughout body at advanced stages. A better understanding malignant mechanism and early diagnosis important fighting ESCC. In this study, we used proteomics to analyze ESCC tissues, aiming defining proteomic...
p16INK4a and p15INK4b genes, which encode two functionally related CDK inhibitors, recently emerged as candidate tumor suppressor genes since they were both localized to 9p21, frequently undergoes hemizygous homozygous deletion in a variety of types. To determine the mode inactivation these human esophageal squamous cell carcinoma (ESCC), we performed multiple molecular analyses 60 ESCC specimens from Linxian, China using DNA methylation assay, LOH analysis, screening SSCP-sequencing. We...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by therapeutic resistance for which the basis poorly understood. Here, we report that DNA and p53-binding protein ATDC/TRIM29, highly expressed in PDAC, plays a critical role damage signaling radioresistance pancreatic cancer cells. Ataxia-telangiectasia group D-associated gene (ATDC) mediated to ionizing radiation vitro vivo mouse xenograft assays. ATDC was phosphorylated directly MAPKAP kinase 2 (MK2) at Ser550 an ATM-dependent...
Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, shown to have antioxidant potential. However, the effect of Iso on APAP-induced liver injury not yet elucidated. The present study investigated hepatoprotective and its underlying mechanism. C57BL/6J mice were used evaluate in vivo HepG2 cells utilized further decipher mechanisms -induced Nrf2 activation. We found that...
Thyroid cancer (THCA) is an increasingly common malignant tumor of the endocrine system, with its incidence rising steadily in recent years. For patients who experience recurrence or metastasis, treatment options are relatively limited, and prognosis poor. Therefore, exploring new therapeutic strategies has become particularly urgent. This study confirmed that effective suppression THCA cell proliferation stimulation apoptosis can be achieved through application Ginsenosides-Rh2. Through...
SGLT-2 inhibitors have revolutionized the management of chronic diseases, demonstrating profound cardiovascular and renal protective effects that extend beyond their original purpose glucose-lowering in T2DM. These agents target fundamental pathophysiological mechanisms, including hemodynamic regulation, metabolic efficiency, inflammation, oxidative stress, making them effective across diverse populations. Landmark clinical trials such as EMPA-REG OUTCOME, CANVAS, DAPA-HF, DAPA-CKD shown...
This study aimed to identify independent predictors of cervical central lymph node metastasis (CLNM), lateral (LLNM), and recurrence in patients with PTC, which could help guide the surgical management these patients. retrospective analyzed data from 542 who underwent thyroid surgery were enrolled The Cancer Genome Atlas Gene Expression Omnibus databases. Patients categorized into two groups based on presence or absence LNM, classified as CLNM LLNM. Data randomly partitioned training...
Licochalcone A (Lico A) exhibits various biological properties, including anti-inflammatory and antioxidant activities. In this study, we investigated the antioxidative potential mechanisms of Lico against tert -butyl hydroperoxide- ( t -BHP-) induced oxidative damage in RAW 264.7 cells. Our results indicated that significantly inhibited -BHP-induced cytotoxicity, apoptosis, reactive oxygen species (ROS) generation reduced glutathione (GSH) depletion but increased glutamate-cysteine ligase...
Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis, propensity for early metastasis and resistance to chemotherapy. Little known about the mechanisms that drive innate therapeutic in pancreatic cancer. The ataxia-telangiectasia group D-associated gene (ATDC) overexpressed cancer promotes tumor growth metastasis. Our study reveals increased ATDC levels protect cells from reactive oxygen species (ROS) via stabilization of nuclear factor erythroid 2-related 2...
Papillary thyroid cancer (PTC) is one of the most prevalent endocrine malignancies. Herein, we aimed to provide a new viewpoint for PTC progression and explore target effective therapy PTC. We found that E26 transformation specific (ETS) variant 4 (ETV4, an ETS family transcription factor) was upregulated in tissues cells. In vitro experiments exhibited silencing ETV4 suppressed cell proliferation cycle progression, while overexpression gained opposite results. Dual-luciferase reporter assay...
Circular RNAs (circRNAs) are a group of regulators that affect the aggressive behaviors several types cancer. Hsa_circ_0001666 (also referred to as hsa_circ_000742) is newly discovered circRNA upregulated in human papillary thyroid carcinoma (PTC) based on microarray analysis. However, role hsa_circ_0001666 PTC progression remains unknown. Thus, aim present study was determine potential function and underlying mechanism PTC. The results demonstrated both clinical samples cell lines. Its...
Transforming growth factor β (TGFβ) signaling normally functions to regulate embryonic development and cellular homeostasis. It is increasingly recognized that TGFβ regulated by cross-talk with other pathways. We previously reported activates protein kinase A (PKA) independent of cAMP through an interaction activated Smad3-Smad4 complex the regulatory subunit PKA holoenzyme (PKA-R). Here we define domains Smad4 PKA-R functional consequences this interaction. Using a series truncation...
Background/aims: MiR-216b and forkhead box M1 (FOXM1) were demonstrated to exert their biological effects on the development progression of tumors. This study aimed investigate expression role miR-216b FOXM1 in tissues cell lines non-small lung cancer (NSCLC). Methods: The expressions NSCLC cells detected by qRT-PCR Western blot analysis. Cell proliferation was measured CCK-8 assay. migration invasion confirmed Transwell Finally, bioinformatics dual-luciferase reporter assay conducted...
The hedgehog pathway has been implicated in the tumorigenesis, tumor progression, and metastasis of numerous human cancers. We generated first fully antibody MEDI-5304 characterized its antitumor activity preclinical toxicology. bound sonic (SHH) Indian (IHH) with low picomolar affinity neutralized SHH IHH cellular mGLI1 reporter assays. inhibited transcription target genes osteoblast differentiation C3H10T1/2 cells. evaluated vivo model systems that allowed us to evaluate two primary...
Induction of DNA damage by ionizing radiation (IR) and/or cytotoxic chemotherapy is an essential component cancer therapy. The ataxia telangiectasia group D complementing gene (ATDC, also called TRIM29) highly expressed in many malignancies. It participates the response downstream telangiectasia-mutated (ATM) and p38/MK2 promotes cell survival after IR. To elucidate mechanisms ATDC-induced IR protection, we performed a mass spectrometry screen to identify ATDC binding partners. We identified...
TAGLN2, an actin-binding protein, functions as a binding protein to actin facilitate the formation of intracellular cytoskeleton structures. TAGLN2 overexpression in papillary thyroid carcinoma (PTC) is reported our previous study. This study aimed examine and molecular mechanisms PTC. The clinical data analysis showed that expression was associated with cervical lymph node metastasis Gain- loss-of-function approaches, well various cellular function, gene profiles, quantitative proteomics,...
Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic hypersensitivity. Immunohistochemistry detect P2X2 P2X3 receptor expression dorsal root ganglia from rats with Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment the model, indicating Simultaneously, ganglia. After bilateral electroacupuncture Tianshu, decreased These...
Background: Papillary thyroid carcinoma (PTC) is one of the most common endocrine malignant tumors.Poor prognoses such as high recurrence rate always appear in PTC patients with cervical lymph node metastasis.The process ubiquitination plays important roles PTC.As ubiquitin E3 ligases, Deltex (DTX) family proteins were reported to associate multiple cancers.However, functions and mechanisms DTX3 are currently unknown.Methods: In this study, expressions examined 114 paired paracancerous...