A5100663898- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Metabolism, Diabetes, and Cancer
- Estrogen and related hormone effects
- Cancer-related gene regulation
- interferon and immune responses
- Diabetes Treatment and Management
- ATP Synthase and ATPases Research
- Plant tissue culture and regeneration
- Phagocytosis and Immune Regulation
- Plant Pathogens and Fungal Diseases
- Plant Physiology and Cultivation Studies
- Signaling Pathways in Disease
- Calcium signaling and nucleotide metabolism
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Plant Reproductive Biology
- Chromatin Remodeling and Cancer
- Protein Tyrosine Phosphatases
- Peptidase Inhibition and Analysis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Actinomycetales infections and treatment
The Ohio State University
2021-2024
Mayo Clinic in Arizona
2019-2024
Shanghai East Hospital
2020-2022
Shanghai Jiao Tong University
2022
Shanghai First People's Hospital
2022
Huazhong University of Science and Technology
2020
Union Hospital
2020
Xinqiao Hospital
2020
ORCID
2020
First Hospital of Jilin University
2017
Abstract Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection. Ablation GSDMD in knockout (KO) mice ( Gsdmd −/− ) significantly attenuates influenza virus-induced weight loss, lung dysfunction, histopathology, mortality compared with wild type (WT) mice, despite similar viral loads. Infected exhibit...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised individuals is associated with prolonged virus shedding and evolution of viral variants. Rapamycin its analogs (rapalogs, including everolimus, temsirolimus, ridaforolimus) are FDA approved as mTOR inhibitors for the treatment human diseases, cancer autoimmunity. Rapalog use commonly an increased susceptibility to infection, which has been traditionally explained by impaired adaptive immunity. Here,...
Abstract Human chromosome 1p35-p36 has long been suspected to harbor a tumor suppressor gene in pancreatic cancer and other tumors. We found that expression of rap1GAP, located this chromosomal region, is significantly down-regulated cancer. Only small percentage preneoplastic intraductal neoplasia lesions lost rap1GAP expression, whereas loss occurred 60% invasive cancers, suggesting contributes progression. In vitro vivo studies showed promotes growth, survival, invasion, may function...
Abstract Some researchers have previously shown that RNAi knockdown of arginyl-tRNA synthetase (ArgRS) before or after a hypoxic injury can rescue animals from death, based on the model organism, C. elegans . However, there has been no study application in treating mammalian ischemic stroke, and its potential mechanism effect brain damage are still unknown. Here, we focused Rars gene, which encodes an synthetase, examined effects permanent middle cerebral artery occlusion rats. To achieve...
Endothelial progenitor cells (EPCs) have been used in clinical trials for the treatment of patients with ischemic diseases, such as myocardial infarction and limb ischemia, they could secrete angiogenic growth factors promote neovascularization. However, employment EPC therapy relies on establishment a noninvasive, timely, effective, safe assessment system. In this study, we recruited superparamagnetic iron oxide nanoparticles (SPION) enhanced magnetic resonance imaging (MRI) to track EPCs...
Abstract SARS-CoV-2 infection in immunocompromised individuals is associated with prolonged virus shedding and evolution of viral variants. Rapamycin its analogs (rapalogs, including everolimus, temsirolimus, ridaforolimus) are FDA-approved as mTOR inhibitors for the treatment human diseases, cancer autoimmunity. Rapalog use commonly increased susceptibility to infection, which has been traditionally explained by impaired adaptive immunity. Here, we show that exposure rapalogs increases...
Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are able to inhibit bone resorption a certain extent and improve formation. GLP-1R single nucleotide polymorphism (SNP) is related its activity, but the relationship between SNP osteoporosis in postmenopausal women was still unclear. This study investigate association mineral density (BMD) Shanghai. Methods: Eight SNPs of were detected (rs3765467, rs1042044, rs2268657, rs6923761, rs2268641, rs2295006, rs4714210 rs10305420) 884...
We demonstrated previously that there is a correlation between glucagon-like peptide-1 (GLP-1) single-nucleotide polymorphism (SNP) and bone mineral density in postmenopausal women. Both GLP-1 glucose-dependent insulinotropic peptide are incretins. The receptor (GIPR) SNP rs10423928 has been extensively studied. However, it not clear whether GIPR gene mutations affect metabolism. aim of this study was to investigate the association women Shanghai. detected 884 Shanghai, assessed. dominant...
<p>Supplementary Figure 7 shows how oncogenic KRAS modulates GLI target gene expression.</p>
<p>Supplementary Figure 7 shows how oncogenic KRAS modulates GLI target gene expression.</p>
Abstract Background: This study aimed to examine the expression of gap junction proteins connexin 32 (CX32) and 43 (CX43) in epileptic foci brain patients with refractory epilepsy, order provide insight into pathogenesis treatment epilepsy. Methods: The experimental group consisted 30 epilepsy who received surgical treatments. control six traumatic injuries underwent emergency surgery. Expression CX32 CX43 was assessed by immunohistochemistry immune electron microscopy surgically extracted...
Increasing evidence suggests that aberrant activation of PI3K/Akt is involved in many human cancers, and inhibition the pathway might be a promising strategy for cancer therapy. The aims this study to evaluate effects combined therapy Phosphatidylinositol 3-Kinase inhibitor (LY294002 ) Paclitaxel athymic mice xenogeneic transplant model lung reveal possible mechanisms involved.Eighteen were randomly divided into 3 groups (control, paclitaxel alone plus LY294002), treated respectively....
<p>PDF file - 30KB, Expression of MYH9 and MYH10 in PANC-1 stable cell lines by RT-qPCR showing higher RNA expression (red) as compared to (blue) PANC1-vo PANC1-CLPTM1L lines.</p>